Osofen Plus 400mg/325mg Tablet is used to relieve symptoms of muscle pain, arthritis pain, dysmenorrhea (painful periods or menstrual cramps), and dental pain and reduces fever. Pain can be temporary (acute) or long-lasting (chronic). Acute pain is, for a short time, caused by damage to the tissues of the muscle, bone, or other organs. In contrast, chronic pain lasts for a long duration and is caused by pathologies like nerve damage, osteoarthritis, etc. Besides this, it is also useful for dental pain, which can occur due to damage to the tooth nerve, infection, decay, extraction or injury.

Osofen Plus 400mg/325mg Tablet is composed of two medicines, namely Ibuprofen and Paracetamol. Ibuprofen is known to have an analgesic and anti-inflammatory effect for reducing mild to moderate pain. It works by blocking the effect of a chemical known as prostaglandin, responsible for inducing pain and inflammation in our body. Paracetamol acts as a mild analgesic and antipyretic (fever reducer). It lowers the elevated body temperature and mild pain by inhibiting the synthesis of a chemical messenger (prostaglandin) and promoting heat loss (through sweating) that helps reset the hypothalamic thermostat. Together, these two medicines help reduce mild to moderate pain in a shorter duration.

Like all medicines, Osofen Plus 400mg/325mg Tablet may cause side effects, although not everybody gets them. Stop taking this medicine if you experience symptoms like tightness of the chest, breathing difficulties, fever, skin rashes, increased heart rate and or in case of any signs of hypersensitivity.

Do not take Osofen Plus 400mg/325mg Tablet if you are allergic to painkillers like aspirin, ibuprofen, naproxen, or diclofenac. It is not recommended for use in children, people with liver disease, heart disease or gastric ulcers/bleeding problems. Osofen Plus 400mg/325mg Tablet may be associated with a small increase in the risk of heart attack (myocardial infarction). Avoid consumption of alcohol as it may damage your liver and cause increased side effects on taking this drug. Consult your doctor if your pain, inflammation, and fever symptoms do not disappear even after ten days.

Osofen Plus 400mg/325mg Tablet comprises Ibuprofen and Paracetamol primarily used to treat mild to moderate pain. Osofen Plus 400mg/325mg Tablet is prescribed mainly to treat pain and relieve discomfort caused by conditions like tooth pain, arthritis, period pain and other types of short-term pains. It helps treat pain by blocking the chemical messenger (prostaglandin) in the brain responsible for causing pain. Ibuprofen works by blocking the effect of a chemical known as prostaglandin, responsible for inducing pain and inflammation in our body. On the other hand, Paracetamol lowers the elevated body temperature and mild pain by inhibiting the synthesis of prostaglandin by promoting heat loss (through sweating) that helps reset the hypothalamic thermostat. Paracetamol has the advantage of producing less gastric irritation than other painkillers like aspirin.

• Nausea
• Vomiting
• Diarrhoea
• Flatulence
• Constipation
• Thrombocytopenia (low level of platelets)
• Neutropenia/leucopenia (low white blood cells)
• Skin rashes (urticaria)
• Peptic ulcers
• Gastrointestinal bleeding
• Dyspepsia
• Abdominal pain
• Colitis (inflammation of the intestine)
• Inflammatory bowel disorder

Caution is advised in people with underlying sensitivity to aspirin and other pain killers. Osofen Plus 400mg/325mg Tablet is contraindicated in children below 12 years of age under 40 kg of weight. If treatment is required for more than three days, consult your doctor. Osofen Plus 400mg/325mg Tablet should be taken with caution if you have an allergy to paracetamol, ibuprofen, aspirin, or other pain killers, highly sensitive reactions (asthma, lip/face/throat swelling), existing stomach ulcer or bleeding associated pain killers, blood clotting disorder, heart diseases (like congestive heart failure), kidney disease, peptic ulcer, another active bleeding (like brain stroke bleeding), and severe dehydration (due to vomiting, diarrhoea). Liver damage might occur if taken for a longer duration as it contains paracetamol. The skin should be closely monitored as skin allergic reactions like Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) have been reported with Osofen Plus 400mg/325mg Tablet. Blood pressure and cardiovascular (heart) status should be monitored closely during the treatment with Osofen Plus 400mg/325mg Tablet, especially in people affected with high blood pressure and who have a history of heart failure.

Drug Interactions: Osofen Plus 400mg/325mg Tablet is shown to interact with various drugs. Some of them include lithium, blood thinner or anticoagulant (warfarin, ticlopidine), anti-arthritis pills (methotrexate), blood pressure or heart medicine, nausea/vomiting medicine (metoclopramide, domperidone), diuretic/water pills (thiazides, furosemide), steroid medicine (prednisone), quinolones antibiotics (ciprofloxacin), respiratory medicines (theophylline, ephedrine), cholesterol-reducing medicine (colestyramine) and antidepressants (duloxetine). These drugs may affect the working of Osofen Plus 400mg/325mg Tablet and may alter its efficacy.

Drug-Food Interactions: Osofen Plus 400mg/325mg Tablet interacts with alcoholic beverages and increases your risk of stomach bleeding.

Drug-Disease Interactions: Osofen Plus 400mg/325mg Tablet should not recommend for people having the liver disease (like Gilbert’s syndrome in which the liver does not process bile), asthma, allergic skin diseases (Stevens-Johnson syndrome, toxic epidermal necrolysis), blood clot disorder, high blood pressure (hypertension), or history of heart failure. Besides this, Osofen Plus 400mg/325mg Tablet should not be given to the children suffering with influenza (flu) or chickenpox. It should also be avoided in case of presence of gastric/duodenal ulcers and low glutathione level.

• WARFARIN
• TICLOPIDINE
• METHOTREXATE
• METOCLOPRAMIDE
• DOMPERIDONE
• FUROSEMIDE
• PREDNISONE
• CIPROFLOXACIN
• THEOPHYLLINE
• EPHEDRINE
• CHOLESTYRAMINE
• DULOXETINE

• Include more glucosamine, chondroitin sulphate, vitamin D, and calcium-enriched supplements. Besides this, turmeric and fish oils can help reduce inflammation in the tissue.

• Please do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do low-impact aerobic exercises like walking on the treadmill, bike riding and swimming. You can also strengthen your muscles by lifting light weights.

• In the chronic condition of arthritis or joint pain, try to include fish like salmon, trout, tuna, and sardines. These fishes are enriched with omega-3 fatty acids that minimum level of chemical called cytokines, which ramp up inflammation.

• Your sitting posture is important, especially when you have pain and inflammation. Try to sit as little as possible and only for a short time. Long-term immobility is harmful in conditions like arthritis. Use back support like a rolled-up towel to minimise pain at the back of your spine curve. Keep your knees and hips at a right angle. Besides this, you can also use a footrest if required.

• Let your doctor know if you are suffering from stomach ulcers as the Osofen Plus 400mg/325mg Tablet may enhance the same.

Pain: Pain can be short-term (acute) or long-term (chronic). Acute pain is, for a short time, caused by damage to the tissues of the muscle, bone, or organs. In contrast, chronic pain lasts for a longer duration. It is caused due to pathologies like nerve damage, Osteoarthritis, and dental pain due to damage to the tooth nerve, infection, decay, extraction, or injury. Many women have painful periods known as dysmenorrhea, most often menstrual cramps. On the other hand, Osteoarthritis is a degenerative disease that results in chronic pain in joints (especially the knee) and stiffness, making daily tasks difficult.

Fever: Fever is not a disease but a sign that your body is trying to fight an infection or illness in which your body's immune system gets activated to fight infections caused by bacteria or viruses. A normal temperature is around 98.6 F but may vary from person to person. Fever is caused due to the 'pyrogen' released by the hypothalamus part of the brain. This pyrogen causes heat-generating effects to match a new higher temperature set point to fight infection.