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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Nov 23, 2024 | 4:50 PM IST
Olmenol Trio 40mg/5mg/12.5mg Tablet is used for lowering high blood pressure (hypertension) by removing extra fluid (electrolytes) from the body. It works by relaxing and widening the narrowed blood vessels. It reduces the heart's workload and makes it more efficient at pumping blood throughout the body. Also, it removes extra water/fluid and certain electrolyte overload from the body. Thus, it lowers fluid overload and high blood pressure, improves blood flow, and reduces the future risk of a heart attack and stroke. In some cases, it may cause common side effects such as nausea, upset stomach, dehydration, headache, diarrhoea, electrolyte imbalance, headache, feeling exhausted, swollen ankles, dizziness, and decreased blood pressure. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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About Olmenol Trio 40mg/5mg/12.5mg Tablet

Olmenol Trio 40mg/5mg/12.5mg Tablet belongs to a group of medications called 'anti-hypertensives' primarily used for lowering high blood pressure (hypertension) by removing extra fluid (electrolytes) from the body. High blood pressure is a chronic condition in which the blood's force against the artery wall is high. As a result, it increases the risk of heart-related diseases like heart attack, heart failure, stroke, irregular heartbeat, and other complications.

Olmenol Trio 40mg/5mg/12.5mg Tablet is a combination of three medicines: Olmesartan medoximil, Amlodipine, and Hydrochlorothiazide. Olmesartan medoximil is a prodrug and breaks down into active form, i.e., olmesartan once absorbed in the GIT (Gastrointestinal tract). An angiotensin receptor blocker (ARB) blocks the hormone angiotensin, thereby relaxing and widening the narrowed blood vessels. Amlodipine is a calcium channel blocker; it reduces the heart's workload and makes it more efficient at pumping blood throughout the body. Hydrochlorothiazide is a diuretic or water pill that removes extra water/fluid and certain electrolyte overload from the body. Together, Olmenol Trio 40mg/5mg/12.5mg Tablet lowers fluid overload, raises blood pressure, improves blood flow, and reduces the future risk of a heart attack and stroke.

Depending upon your medical condition, you are advised to take Olmenol Trio 40mg/5mg/12.5mg Tablet for as long as your doctor has prescribed it for you. The most common side effects of Olmenol Trio 40mg/5mg/12.5mg Tablet are nausea, upset stomach, dehydration, headache, diarrhoea, electrolyte imbalance, headache, feeling exhausted, swollen ankles, dizziness, and decreased blood pressure in some cases. Most of these side effects of Olmenol Trio 40mg/5mg/12.5mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Do not use potassium supplements or salt substitutes unless your doctor tells you. In rare cases, Olmenol Trio 40mg/5mg/12.5mg Tablet can cause a condition that results in a skeletal muscle problem, leading to further kidney failure. If you notice unexplained muscle pain, dark-coloured urine, tenderness, or weakness, especially if you also have a fever or unexplained tiredness, immediately contact the doctor. Try not to stop taking this medicine of your own. Let your doctor know about this, as it may cause a rise in blood pressure and increase heart disease and stroke risk. Inform your doctor if you are suffering from kidney, liver, heart disease, or diabetes. If you are pregnant or breastfeeding, do not take Olmenol Trio 40mg/5mg/12.5mg Tablet as it is a category D pregnancy drug and may harm the baby. Do not use the Olmenol Trio 40mg/5mg/12.5mg Tablet if you cannot urinate, are dehydrated, have low blood pressure (hypotension), or have had cardiogenic shock (sudden stopping blood flow to the heart). Please tell your doctor if you are taking any other medicines or are allergic to this medicine. Reducing table salt (sodium chloride) in your food often helps lower blood pressure.

Uses of Olmenol Trio 40mg/5mg/12.5mg Tablet

Treatment of Hypertension (high blood pressure)

Medicinal Benefits

Olmenol Trio 40mg/5mg/12.5mg Tablet belongs to a group of medications called 'anti-hypertensives' primarily used for lowering high blood pressure (hypertension) by removing extra fluid (electrolytes) from the body. Olmenol Trio 40mg/5mg/12.5mg Tablet is a combination of three medicines: Olmesartan medoximil, Amlodipine, and Hydrochlorothiazide. Olmesartan medoximil is a prodrug and breaks down into active form, i.e., olmesartan once absorbed in the GIT (Gastrointestinal tract). An angiotensin receptor blocker (ARB) blocks the hormone angiotensin, thereby relaxing and widening the narrowed blood vessels. Amlodipine is a calcium channel blocker; it reduces the heart's workload and makes it more efficient at pumping blood throughout the body. Hydrochlorothiazide is a diuretic or water pill that removes extra water/fluid and certain electrolyte overload from the body. Together, Olmenol Trio 40mg/5mg/12.5mg Tablet lowers fluid overload, raises blood pressure, improves blood flow, and reduces the future risk of a heart attack and stroke.

Side Effects of Olmenol Trio 40mg/5mg/12.5mg Tablet

  • Nausea

  • Upset stomach

  • Dehydration

  • Headache

  • Dry mouth

  • Muscle cramps/weakness

  • Fast/slow/irregular heartbeat

  • Diarrhoea

  • Electrolyte imbalance

  • Headache

  • Feeling exhausted

  • Swollen ankles

  • Dizziness

  • Decreased blood pressure

Directions for Use

Swallow the medicine as a whole with water; do not crush, break or chew it.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not use Olmenol Trio 40mg/5mg/12.5mg Tablet if you are pregnant, planning for pregnancy, or unable to urinate (anuria). If you have diabetes and taking Olmenol Trio 40mg/5mg/12.5mg Tablet with other blood pressure-lowering pills like 'aliskiren,' immediately stop taking both together and consult a doctor. Besides this, it is contraindicated in low blood pressure (hypotension), cardiogenic shock (sudden stopping of blood flow to the heart), and aortic stenosis (heart valve problem). Olmenol Trio 40mg/5mg/12.5mg Tablet may pass into breast milk, so before starting Olmenol Trio 40mg/5mg/12.5mg Tablet, either you need to stop nursing or you should not take Olmenol Trio 40mg/5mg/12.5mg Tablet while breastfeeding. Please inform your doctor before surgery if you are taking Olmenol Trio 40mg/5mg/12.5mg Tablet as it needs to be stopped because it might lower the blood pressure further if taken along with local anaesthesia. Avoid potassium salt or its substitute intake while using Olmenol Trio 40mg/5mg/12.5mg Tablet to avoid any electrolyte imbalance. Olmenol Trio 40mg/5mg/12.5mg Tablet can pass into breast milk, but its effect on the baby is unknown. So, it is better to tell your doctor if you take Olmenol Trio 40mg/5mg/12.5mg Tablet and breastfeeding.

Therapeutic Class

ANTI- HYPERTENSIVES

Drug-Drug Interactions

verifiedApollotooltip
Olmesartan medoxomilAliskiren
Critical
AmlodipineDantrolene
Critical

Drug-Food Interactions

verifiedApollotooltip
OLMESARTAN MEDOXOMIL-40MG+AMLODIPINE-5MG+HYDROCHLOROTHIAZIDE-12.5MGPotassium rich foods
Moderate

Diet & Lifestyle Advise

  • Create a well-balanced and healthy diet that includes vegetables, fruits, whole grains, legumes, omega-3-rich foods, and lean protein sources.

  • Keep your weight under control with a BMI of 19.5-24.9.

  • Avoid chronic stress, as it can raise your blood pressure.

  • Spend time with your loved ones to cope with stress and practice mindfulness techniques.

  • Be mindful of salt; consume no more than 2,300 mg each day.

  • Limit or avoid alcohol consumption.

  • Quitting smoking is the best strategy to lower the risk of heart disease.

Habit Forming

No

What if I have taken an overdose of Olmenol Trio 40mg/5mg/12.5mg Tablet

Do not take more than the prescribed dose of Olmenol Trio 40mg/5mg/12.5mg Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.
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Alcohol

Unsafe

You are recommended not to consume alcohol and Olmenol Trio 40mg/5mg/12.5mg Tablet to avoid unpleasant side effects like drowsiness, dizziness, and liver damage.

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Pregnancy

Unsafe

Olmenol Trio 40mg/5mg/12.5mg Tablet is not recommended during pregnancy as it contains Olmesartan, which is a category D pregnancy drug. This medicine may cause fetal damage and can affect the unborn baby (fetus).

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Breast Feeding

Unsafe

Olmenol Trio 40mg/5mg/12.5mg Tablet is known to pass breast milk, but its effect on the baby is unknown. So, before breastfeeding, let your doctor know about this. Either you need to stop breastfeeding for using Olmenol Trio 40mg/5mg/12.5mg Tablet or stop taking Olmenol Trio 40mg/5mg/12.5mg Tablet.

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Driving

Caution

Drive with caution; Olmenol Trio 40mg/5mg/12.5mg Tablet usually causes drowsiness and affects driving ability.

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Liver

Caution

Olmenol Trio 40mg/5mg/12.5mg Tablet to be taken with caution, especially if you have or have had a history of liver disease. Your doctor will have to change the dosage depending on your medical condition and your reaction to treatment.

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Kidney

Caution

Olmenol Trio 40mg/5mg/12.5mg Tablet to be taken with caution, especially if you have had a history of kidney disease. Your doctor will have to change the dosage depending on your medical condition and your reaction to treatment.

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Children

Caution

Efficacy and safety of Olmenol Trio 40mg/5mg/12.5mg Tablet have not been established in children. If prescribed, it should be strictly under medical supervision and only if the benefits outweigh the harm.

Country of origin

India
Other Info - OL52356

Author Details

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FAQs

Olmenol Trio 40mg/5mg/12.5mg Tablet is used for lowering high blood pressure (hypertension) by removing extra fluid (electrolytes) from the body.
Olmenol Trio 40mg/5mg/12.5mg Tablet is a combination of three medicines: Olmesartan medoximil, Amlodipine, and Hydrochlorothiazide. Olmesartan medoximil relaxes and widens the narrowed blood vessels. Amlodipine reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Hydrochlorothiazide is a diuretic or water pill that removes extra water/fluid and certain electrolyte overload from the body. Together, Olmenol Trio 40mg/5mg/12.5mg Tablet lowers fluid overload, raises blood pressure, improves blood flow, and reduces the future risk of a heart attack and stroke.
Olmenol Trio 40mg/5mg/12.5mg Tablet can be safely taken as long as your doctor prescribes it. Conditions such as high blood pressure are life-long conditions, and one should not abruptly discontinue it without discussing it with a doctor. Discontinuing Olmenol Trio 40mg/5mg/12.5mg Tablet may lead to increased blood pressure and a high risk of heart attack and stroke.
It's unlikely that Olmenol Trio 40mg/5mg/12.5mg Tablet affects fertility in men or women. However, in some cases, some water pills like hydrochlorothiazide may lead to erectile dysfunction. For the best advice, please consult your doctor.
Please inform your doctor before surgery if you are taking Olmenol Trio 40mg/5mg/12.5mg Tablet as it needs to be stopped because it might lower the blood pressure further if taken along with local anaesthesia.
Do not use Olmenol Trio 40mg/5mg/12.5mg Tablet if you are pregnant, planning for pregnancy, or unable to urinate. If you have diabetes and taking Olmenol Trio 40mg/5mg/12.5mg Tablet with other blood pressure-lowering pills like 'aliskiren', immediately stop taking both together and consult a doctor.
High blood pressure during pregnancy is called 'Pregnancy-induced hypertension (PIH). It is harmful to both the baby and the mother. In the mother, very high blood pressure can cause seizures (fits), headache, swelling of feet, kidney damage, and a higher risk of bleeding during pregnancy and delivery. This can also affect the baby by causing abnormal fetal heart rate, risk of stillbirth, and a small baby. So, during pregnancy, you should have regular blood pressure monitoring. Visit your Obstetrician if you have any concerns about blood pressure during pregnancy.
Yes, Olmenol Trio 40mg/5mg/12.5mg Tablet is known to cause ankle swelling (oedema) upon long-term use as Olmenol Trio 40mg/5mg/12.5mg Tablet amlodipine. Please try to keep your feet up when sitting for long hours. If the problem persists still, consult your doctor and do as advised.
Olmenol Trio 40mg/5mg/12.5mg Tablet can be taken with or without food or as advised by the doctor.
You are not recommended to stop Olmenol Trio 40mg/5mg/12.5mg Tablet, as stopping it may raise blood pressure and increase the risk of heart disease and stroke. Therefore, inform your doctor if you intend to stop taking Olmenol Trio 40mg/5mg/12.5mg Tablet or if you experience any difficulty while taking Olmenol Trio 40mg/5mg/12.5mg Tablet.
To control high blood pressure, it’s important to follow a balanced diet that includes proteins, whole grains, and fiber-rich fruits and vegetables. Limit your intake of carbohydrates, salt, and sugar. Before making any changes to your diet or eating habits, consult your doctor. Regular exercise and weight loss are also recommended. Avoid smoking and drinking.
You may observe a decrease in your blood pressure within 2 weeks of starting Olmenol Trio 40mg/5mg/12.5mg Tablet. But to notice the full effects of Olmenol Trio 40mg/5mg/12.5mg Tablet, it may take up to 8 weeks.
You are recommended to take the first dose before bedtime, as Olmenol Trio 40mg/5mg/12.5mg Tablet can cause dizziness. After the first dose, you can take Olmenol Trio 40mg/5mg/12.5mg Tablet at any time of day, but it’s essential to take it at the same time each day for consistency and to help you remember.
You may feel dizzy after taking Olmenol Trio 40mg/5mg/12.5mg Tablet as it is one of its side effects. Avoid driving if you feel dizzy. This condition doesn’t require any medical treatment as it will gradually reduce over time. Consult your doctor, if the condition persists longer.
Olmenol Trio 40mg/5mg/12.5mg Tablet does not usually cause weight gain. Change your lifestyle and maintain a balanced diet if you observe any changes in your weight. However, in rare cases, chronic diarrhoea with weight loss may occur. If the patient experiences diarrhoea while taking Olmenol Trio 40mg/5mg/12.5mg Tablet and the cause is unknown, consult a doctor.
Olmenol Trio 40mg/5mg/12.5mg Tablet includes side effects such as painful joints, fast heartbeat, skin rash or itchiness, chest tightness, shortness of breath, weak muscles, swelling of feet, hands, or ankles. Please, consult your doctor if you experience any of these side effects.
Take the Olmenol Trio 40mg/5mg/12.5mg Tablet whole with a glass of water; do not crush or chew it. To help you remember, try to take it at the same time every day.
Before taking Olmenol Trio 40mg/5mg/12.5mg Tablet, inform your doctor if you have kidney, liver or heart disease, diabetes, or asthma. Also, let your doctor know about all the medications you might be taking.
You are recommended to be cautious while driving or operating machinery after taking Olmenol Trio 40mg/5mg/12.5mg Tablet as it may cause drowsiness which affects the driving ability.
Inform your doctor about all the medications you are currently taking, as Olmenol Trio 40mg/5mg/12.5mg Tablet may interact with other drugs, potentially causing harmful reactions. It may interact with medications such as antidepressants (lithium), heart rhythm drugs (digoxin), blood thinners (aspirin), antidiabetics (metformin, insulin), erectile dysfunction treatments (sildenafil), cholesterol-lowering drugs (simvastatin), immune-suppressants (cyclosporine), other anti-hypertensives (atenolol), pain relievers (ibuprofen), and ulcer medications (carbenoxolone).

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