Nise Gel belongs to a class of medications called 'topical analgesic' (pain killer) primarily used to relieve joint pain, low back pain, muscle sprain and sports injuries. Besides this, it also reduces pain and swelling in muscles and joints in the conditions of joint disorders like osteoarthritis and rheumatoid arthritis. Arthritis is a condition that causes swelling of one or more joints resulting in pain and stiffness of joints that worsen over time.

Nise Gel is a combination of four painkillers/analgesics: Nimesulide, Capsaicin, Methyl salicylate and one cooling agent (Menthol). Nimesulide and Methyl salicylate belong to the class of non-steroidal anti-inflammatory drug (NSAIDs) or painkillers that works by blocking the release of certain chemical messengers in the brain responsible for causing pain and symptoms of inflammation such as redness and swelling. Capsaicin is an analgesic that works by affecting the chemical messenger in the brain (neurotransmitter) that transmits pain signals to the brain, thereby reducing the perception of pain. Menthol acts as a cooling agent that relieves pain initially by cooling the skin, followed by warming it up. This action of cooling and warming up distracts from the pain and helps improve blood circulation.

Nise Gel is only for external use. Take a small amount of Nise Gel on the finger and apply it as a thin layer on the clean and dry affected area. Avoid contact of Nise Gel with nose, ears, mouth or eyes. If Nise Gel comes in contact with these areas accidentally, rinse with water thoroughly. Your doctor will advise you how often you use Nise Gel based on your medical condition. In some cases, you may experience redness, itching, irritation or a burning sensation at the site of application. Most of these side effects of Nise Gel do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Nise Gel or any other medicines, please tell your doctor. If pregnant or breastfeeding, please inform your doctor before taking Nise Gel. Do not consume alcohol with Nise Gel as it may increase the risk of stomach bleeding. Do not apply heat or wrap the treated area of the skin with bandages. Avoid using Nise Gel in more than prescribed doses or on a large area of skin for a prolonged time, as it may cause adverse effects. Do not apply Nise Gel on cuts, wounds or damaged skin. If you have asthma, high blood pressure, diabetes, blood clots, bleeding in the stomach or intestines, stomach ulcers, oedema (swelling due to fluid retention or overload), liver, kidney or heart problems, inform your doctor before taking Nise Gel.

Nise Gel is a combination of three painkillers/analgesics (Nimesulide, Capsaicin, Methyl salicylate) and one cooling agent (Menthol). Nimesulide and Methyl salicylate belong to the class of non-steroidal anti-inflammatory drug (NSAIDs) or painkillers that works by blocking the release of certain chemical messengers in the brain responsible for causing pain and symptoms of inflammation such as redness and swelling. Capsaicin is an analgesic that works by affecting the chemical messenger in the brain (neurotransmitter) that transmits pain signals to the brain, thereby reducing the perception of pain. Menthol acts as a cooling agent that relieves pain initially by cooling the skin, followed by warming it up. Cooling and warming up distracts from the pain and helps improve blood circulation.

• Irritated skin
• Burning sensation
• Stinging sensation
• Red skin or rashes
• Pruritus
• Desquamation
• Erythema

If you are known to be allergic to Nise Gel or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, please inform your doctor before taking Nise Gel. Do not consume alcohol with Nise Gel as it may increase the risk of stomach bleeding. Do not apply heat or wrap the treated area of the skin with bandages. Avoid using Nise Gel in more than prescribed doses or on a large area of skin for a prolonged time, as it may cause adverse effects. Do not apply Nise Gel on cuts, wounds or damaged skin. Wait for a minimum of 10 minutes before wearing clothes or gloves over the treated area. If you have asthma, high blood pressure, diabetes, blood clots, bleeding in the stomach or intestines, stomach ulcers, edema (swelling due to fluid retention), liver, kidney or heart problems, inform your doctor before taking Nise Gel.

Drug-Drug Interaction: Nise Gel may have interaction with pain killers (celecoxib), blood thinners (warfarin), respiratory medicines (theophylline), insulin, anti-epileptics (phenytoin), anti-arthritis or anti-cancer agents (methotrexate), immune system affecting medicines (cyclosporine), anti-HIV (didanosine).

Drug-Food Interaction: No interactions found.

Drug-Disease Interaction: If you have asthma, high blood pressure, diabetes, blood clots, bleeding in the stomach or intestines, stomach ulcers, edema (swelling due to fluid retention), liver, kidney or heart problems, inform your doctor before taking Nise Gel.

• CELECOXIB
• WARFARIN
• THEOPHYLLINE
• INSULIN
• PHENYTOIN
• METHOTREXATE
• CYCLOSERINE
• DIDANOSINE

• Maintain a healthy body weight, as obesity may also cause joint pains. Please do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do stretching, low impact aerobic exercises like walking on a treadmill, bike riding and swimming. You can also strengthen your muscle strength by lifting light weights.
• Include more glucosamine, chondroitin sulfate, Vitamin D, and calcium-enriched supplements. Besides this, turmeric and fish oils can help reduce inflammation in the tissue.
• In the chronic conditions of arthritis or joint pain, fish like salmon, trout, tuna and sardines. These fishes are enriched with omega-3 fatty acids, which help in reducing inflammation (redness and swelling) and protect the heart.
• Your sitting posture is important, especially when you have pain and inflammation. Try to sit as little as possible and only for a short time (10-15 min). Use back support like a rolled-up towel at the back of your curve to minimize pain. Besides this, you can use a footrest if required.
• Avoid consumption of alcohol and quit smoking.

• Avoid contact of Nise Gel with nose, mouth or eyes. If Nise Gel comes in contact with these areas accidentally, rinse with water thoroughly. Wash your hands before and after using Nise Gel if your hands are not affected.

Arthritis: There are various types of arthritis, the most prevalent of which are osteoarthritis and rheumatoid arthritis. Stiffness, joint pain, redness, tenderness, swelling in and around joints, and decreased joint mobility are some of the signs and symptoms of arthritis. With age, obesity, prior joint damage, or family history, arthritis risk rises. Inappropriate medication, physical therapy, or even surgery may help to lessen arthritis symptoms and improve quality of life.