Nildep 50 mg Tablet belongs to a group of medicines called 'tricyclic anti-depressants' used to treat depression. Additionally, Nildep 50 mg Tablet is also used to treat bed-wetting at night in children aged 6 years and older. Depression is a mood disorder characterised by sadness, unhappiness, anger, hopelessness or loss that interferes with a person’s daily activities.
 
Nildep 50 mg Tablet contains ‘Imipramine’, which increases the activity of certain natural substances (neurotransmitters) in the brain required for mental balance, thereby regulating mood and treating depression. It also reduces childhood enuresis or bed-wetting in the children older than 6-7 years of age by relaxing the urinary bladder muscle, which lightens the sleep.
 
You are advised to take Nildep 50 mg Tablet for as long as your doctor has prescribed it for you depending on your medical condition and response to the treatment. In some cases, you may experience certain common side-effects such as dry mouth, nausea, vomiting, increased blood pressure, lack of coordination, swelling of the breast and weakness.  You are advised to talk to your doctor if you experience these side-effects persistently.
 
Please do not stop taking Nildep 50 mg Tablet without consulting your doctor as it could lead to withdrawal symptoms. Consult your doctor if you are pregnant or breastfeeding. Avoid driving or operating machinery as Nildep 50 mg Tablet may cause impaired alertness, drowsiness or blurred vision. Nildep 50 mg Tablet is not recommended for children below 6 years as safety and effectiveness have not been established. Avoid consuming alcohol with Nildep 50 mg Tablet as it could lead to increased drowsiness. Keep your doctor informed about your health condition and medicines to rule out any side-effects.

Nildep 50 mg Tablet belongs to a group of medicines called tricyclic anti-depressants. Nildep 50 mg Tablet is used to treat depression. Nildep 50 mg Tablet works by increasing the activity of certain natural substances in the brain needed for mental balance, thereby regulating mood and treating depression. Additionally, Nildep 50 mg Tablet is used as an adjunct therapy in reducing bed-wetting at night in children aged 6-7 years and older. Nildep 50 mg Tablet helps to control childhood enuresis or bed-wetting as a part of its anti-depressant effect.

• Dry mouth
• Nausea
• Vomiting
• Increased blood pressure
• Lack of coordination
• Swelling of breast
• Weakness
• Trouble urinating
• Blurred vision
• Breast swelling in men and women

Do not take Nildep 50 mg Tablet if you are allergic to any of its contents; if you are taking monoamine oxidase inhibitors (MAOI) or have taken them in the last 14 days, if you have heart diseases, mania, porphyria, glaucoma or are unable to pass urine. Avoid taking buprenorphine/opioids with Nildep 50 mg Tablet as it could lead to serotonin syndrome. Inform your doctor if you have/had schizophrenia or manic depression, alcohol withdrawal, enlarged prostate, overactive thyroid, epilepsy, low blood pressure, poor circulation, panic attacks, a tumour of the adrenal gland, or if you are being given electroconvulsive therapy. Talk to your doctor immediately if you have suicidal thoughts such as killing or harming yourself. Consult your doctor if you are pregnant or breastfeeding. Avoid driving or operating machinery as Nildep 50 mg Tablet may cause impaired alertness, drowsiness, or blurred vision. Nildep 50 mg Tablet is not recommended for children below 6 years as safety and effectiveness have not been established. Avoid consuming alcohol with Nildep 50 mg Tablet as it could lead to increased drowsiness. Rise slowly from sitting or lying position as Nildep 50 mg Tablet causes dizziness on standing suddenly.

Drug-Drug Interactions: Nildep 50 mg Tablet may interact with anti-depressants (fluoxetine, fluvoxamine, duloxetine, escitalopram, sertraline), antipsychotics (aripiprazole, quetiapine), anti-convulsant (carbamazepine, phenytoin, phenobarbital, pregabalin, topiramate), benzodiazepine (diazepam, nitrazepam, oxazepam, alprazolam, clonazepam), pain killer (aspirin, tramadol, codeine, dihydrocodeine), anti-HIV (ritonavir), antacid (cimetidine, esomeprazole), blood thinner (warfarin), skeletal muscle relaxant (cyclobenzaprine), anti-anxiety (alprazolam) and hormone (levothyroxine).

Drug-Food Interactions: Do not take St. John’s wort (herbal supplement to treat depression) along with Nildep 50 mg Tablet .

Drug-Disease Interactions: Inform your doctor if you have epilepsy, low blood pressure, overactive thyroid, urination problems or enlarged prostate, glaucoma, diabetes, schizophrenia, mania, pheochromocytoma (tumour of the adrenal gland), heart, kidney or liver problems.

• FLUOXETINE
• FLUVOXAMINE
• DULOXETINE
• ESCITALOPRAM
• SERTRALINE
• ARIPIPRAZOLE
• QUETIAPINE
• CARBAMAZEPINE
• PHENYTOIN
• PHENOBARBITAL
• PREGABALIN
• TOPIRAMATE
• DIAZEPAM
• NITRAZEPAM
• OXAZEPAM
• ALPRAZOLAM
• CLONAZEPAM
• ASPIRIN
• TRAMADOL
• CODEINE
• DIHYDROCODEINE
• RITONAVIR
• CIMETIDINE
• ESOMEPRAZOLE
• WARFARIN
• CYCLOBENZAPRINE
• LEVOTHYROXINE

• Maintain a healthy diet and exercise regularly as it helps in improving overall health and boosts self-esteem.
• Regularly attend therapy sessions.
• Perform meditation and yoga. This helps in relieving stress and provides relaxation.
• Follow a regular sleep pattern to improve the amount and quality of sleep you get.
• Include foods rich in omega fatty acids such as fish, nuts, fresh fruits, vegetables and olive oils.
• Neurotransmitters are made up of amino acids. Amino acid-rich foods such as meat, dairy products, and certain fruits and vegetables help in the proper maintenance of neurotransmitters. 
• Complex carbohydrates help in stimulating serotonin (a feel-good neurotransmitter). These include whole grains, legumes, spinach, broccoli, oranges and pears.
• Exercising helps in the production of the body’s natural anti-depressants. It also helps in relieving stress, improves mood, boosts self-esteem and provides restful sleep.
• Avoid smoking and alcohol consumption.
• Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

• Close monitoring of patients taking Nildep 50 mg Tablet for suicidal behaviour, clinical worsening, or unusual changes in behaviour is recommended. Consult the doctor immediately if the patient experiences suicidal thoughts such as killing or harming oneself.
• Talk to your doctor before taking Nildep 50 mg Tablet if you are due to have any surgery that involves an anaesthetic, including dental surgery. 
• Your doctor may advise regular blood tests and liver functioning tests while taking Nildep 50 mg Tablet .
• Nildep 50 mg Tablet may cause problems with your teeth, so a regular dental check-up is advised.

Depression: Depression is a mental health disorder characterised by a persistent and intense feeling of sadness for an extended duration of time. It mainly impacts mood, behaviour and other physical functions, such as sleep and appetite. Symptoms include sadness, loss of interest, appetite changes, sleep problems, restlessness, lack of energy, feeling worthless or guilty, thoughts of harming oneself, difficulty in concentrating, making decisions and thinking. The exact cause of depression is unknown. However, factors such as stress, changes in hormone levels, alcohol or drug abuse, abuse during childhood, certain medical conditions and medications might increase the risk of developing depression. 

Bed-wetting: Childhood enuresis is also known as bed-wetting in children. In most cases, children are toilet trained by the age of 5, but generally, there is no target date for complete bladder control development. A small number of children still wet the bed even after the age of 7 years. This may or may not be purposeful, and the condition is not diagnosed until the child is 5 years or older. The causes could be a small bladder, urinary tract infections, stress and developmental delays that could interfere with toilet training. Symptoms include repeated bed-wetting, wetting in the clothes and wetting at least twice a week for 3 months.