Metavate 1gm Tablet is used to prevent or treat peptic ulcers or gastrointestinal ulcers. A peptic ulcer is a sore on the stomach's lining or the first part of the small intestine (duodenum). An ulcer or sores of the stomach region is called a gastric ulcer, while an ulcer of the duodenum is known as a duodenal ulcer.

Metavate 1gm Tablet contains 'Sucralfate', which works by forming a protective barrier or coat over the ulcer so that digestive enzymes, acid and bile salts cannot further irritate the lining of the stomach and duodenum. This protects the ulcer from the stomach's acid, allowing it to heal.

Your doctor will advise you on how often you take Metavate 1gm Tablet based on your medical condition. Some people may experience common side effects like constipation, dizziness, sleepiness, dry mouth, blurred vision, and diarrhoea. Most of these side effects of Metavate 1gm Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Avoid taking any antacid like magnesium hydroxide or aluminium hydroxide within 30 minutes before or after taking Metavate 1gm Tablet. If you are known to be allergic to Metavate 1gm Tablet or active and inactive ingredients present on it, please tell your doctor. If you are pregnant or breastfeeding, it is advised to consult a doctor before using Metavate 1gm Tablet. Duodenal ulcer tends to be a recurrent disease. Try not to stop taking Metavate 1gm Tablet of your own. Stopping a sudden intake of Metavate 1gm Tablet will not influence the frequency or severity of future ulceration. Let your doctor know if you have any kidney problems. People with reduced kidney function may be more likely to experience side effects of aluminium accumulation with Metavate 1gm Tablet. The dose adjustment is necessary for patients with kidney disease and elderly patients.

Metavate 1gm Tablet is a class of anti-ulcer drugs prescribed for treating or preventing the return of duodenal ulcers (ulcers located in the first part of the small intestines). Metavate 1gm Tablet works by forming a protective barrier or coat over the ulcer to pepsin and bile and inhibits the diffusion of gastric acid. This protects the ulcer from the stomach's acid, allowing it to heal. Metavate 1gm Tablet exhibits a cytoprotective effect and forms a viscous, adhesive barrier on the surface of the intact intestinal mucosa and the stomach. Metavate 1gm Tablet stimulates the synthesis and release of gastric mucosal prostaglandins, bicarbonate, and the epidermal growth factor, which promotes healing.

• Constipation

• Dizziness

• Sleepiness

• Dry mouth

• Nausea

You should avoid taking Metavate 1gm Tablet if you are allergic to Metavate 1gm Tablet or other ingredients present in it, have kidney disease, stomach/intestine problems (delayed gastric emptying), are pregnant or planning for pregnancy, and are a breastfeeding mother. Caution is required before giving Metavate 1gm Tablet to elderly patients. Metavate 1gm Tablet contains aluminium, which is normally removed by your kidney. Therefore, older adults and people with kidney problems may be at greater risk for developing high aluminium levels while using this drug with other products containing aluminium (e.g. antacids). The safety and effectiveness in children are not established; please consult your doctor before giving Metavate 1gm Tablet to children.

Drug-Drug Interactions: Metavate 1gm Tablet interacts with the anti-HIV drug (dolutegravir), vitamin D analogues (doxercalciferol, paricalcitol), antibiotic (ciprofloxacin, gemifloxacin, levofloxacin), antidiabetic (acarbose, metformin, glipizide, glimepiride, glyburide), antacid drug (magaldrate, aluminium hydroxide) blood thinner (warfarin).

Drug-Food Interactions: Drinking alcohol and nicotine (tobacco) with Metavate 1gm Tablet may cause dehydration and elevate the level of stomach acid, thereby decreasing Metavate 1gm Tablet efficacy.

Drug-Disease Interactions: Before taking Metavate 1gm Tablet, inform your doctor if you have any kidney or liver disease as a dose of Metavate 1gm Tablet needs to be adjusted.

• DOLUTEGRAVIR
• DOXERCALCIFEROL
• PARICALCITOL
• CIPROFLOXACIN
• GEMIFLOXACIN
• LEVOFLOXACIN
• ACARBOSE
• METFORMIN
• GLIPIZIDE
• ALUMINUM HYDROXIDE
• WARFARIN

• Avoid intake of acid or heartburn triggering foods or drinks like peppermint, chocolate, onions, caffeinated beverages, citrus fruits or juices, tomatoes, and high-fat and spicy foods.

• Eating five or six smaller meals throughout the day rather than three large meals. It can help reduce the production of stomach acid.

• Avoid taking alcohol and smoking cigarettes and red meat. It increases the production of stomach acid and makes symptoms worse. It can also cause erosion of the stomach lining.

• Include the high fiber-containing foods, leafy green veggies (kale, spinach), green tea in your meal. Fermented dairy products like miso, sauerkraut, and kimchi contain probiotics which help in the prevention of excess acid production.

• Cranberry juice can be beneficial in peptic ulcers and H. pylori infections.

Metavate 1gm Tablet is prescribed for acute or short-term conditions of duodenal ulcer. Do not take Metavate 1gm Tablet for more than eight weeks. If still, your duodenal ulcer persists, stop taking Metavate 1gm Tablet and contact a doctor. Metavate 1gm Tablet contains aluminium, so if you are a kidney patient, let your doctor know about this before taking Metavate 1gm Tablet.

Duodenal ulcer: It is a sore that forms in the lining of the small intestine just beyond the stomach (duodenum). The stomach makes a strong acid that kills germs and helps you digest food. To protect themselves against this acid, duodenum cells make a barrier from mucus. If this barrier is damaged, an ulcer can form. The main cause of this barrier damage is infection with bacteria (H. pylori), medicines like NSAIDs or painkillers (aspirin, ibuprofen). If you have a duodenum ulcer, you might have symptoms like pain in the stomach or abdomen (this might come and go and is relieved by taking an antacid), indigestion, nauseous, feeling full after taking a small amount of food, blood or black stools.