Meqsel 0.5 mg Tablet is an anti-cancer medicine used in the treatment of various types of cancers. Cancer is a disease caused by the abnormal growth of cells that divide uncontrollably. This medicine is used as a single agent in treating patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutation. It is also used along with dabrafenib in treating anaplastic thyroid cancer, non-small cell lung cancer, and unresectable or metastatic solid tumors with BRAF V600E mutation.

Meqsel 0.5 mg Tablet contains Trametinib, which belongs to the class of medicines known as kinase inhibitors. It works by inhibiting the action of an enzyme (tyrosine kinase) and thus stops the abnormal growth of cancer cells.

Meqsel 0.5 mg Tablet may cause certain side effects such as diarrhoea, decreased appetite, nausea, vomiting, tiredness, itching, rash, headache, fever, increased blood pressure, chills, cough, abdominal pain, and oedema. Inform your doctor if any of these side effects bother you. Meqsel 0.5 mg Tablet should be taken as prescribed by your doctor.

If you are allergic to Meqsel 0.5 mg Tablet or its components, inform your doctor. Before taking Meqsel 0.5 mg Tablet , inform your doctor if you have/had liver or kidney disease, calcium deficiency, heart problems, increased blood pressure, seizures, bleeding disorders, vision problems, and a history of blood clots. This medicine is known to cause embryo-fetal toxicity. Hence, not recommended for use in pregnancy. If you are breastfeeding, inform your doctor before starting the treatment with Meqsel 0.5 mg Tablet .

Meqsel 0.5 mg Tablet contains Trametinib, which is used in treating different types of cancer. It works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body. It also decreases the blood supply to cancer tumors to slow down the growth of the tumor.  In this way, Meqsel 0.5 mg Tablet stops the production, spread and growth of cancerous cells.

• Nausea
• Vomiting
• Diarrhoea
• Loss of appetite
• Tiredness
• Muscle/joint pain
• Dizziness
• Weakness
• Cough
• Headache
• Itching
• Rash
• Abdominal pain
• Vision problem
• Increased blood pressure

To treat your condition effectually, continue taking Meqsel 0.5 mg Tablet for the period that your doctor has prescribed. Avoid taking Meqsel 0.5 mg Tablet if you are allergic to it or any other components present in it. Caution should be exercised if you have/had liver or kidney disease, heart disease, blood or bleeding disorders, diabetes, eye problems, or gastrointestinal disorders. Inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment, as this medicine is known to cause embryo-fetal toxicity. Breastfeeding should be discontinued in nursing mothers during the treatment as it passes into breast milk and may cause a possible risk to the infant. Avoid driving and operating machines, as this medicine may cause visual disturbances. This medicine is not recommended for use in children below six years of age as the safety and efficacy are not established. Meqsel 0.5 mg Tablet may cause hypertension, thrombotic events, hemorrhagic events, ocular toxicity, cardiomyopathy, interstitial lung disease, colitis, gastrointestinal perforation, serious febrile reactions, severe skin reactions, venous thromboembolism and hyperglycemia in some patients. Hence, inform your doctor about your complete medication and medical history before taking Meqsel 0.5 mg Tablet .

Drug-Drug Interactions: Meqsel 0.5 mg Tablet may have interaction with CYP3A inhibitors (itraconazole, clarithromycin, fluconazole, erythromycin, diltiazem), CYP2C8 inhibitors (clopidogrel, warfarin, verapamil, ritonavir), etc.

Drug-Food Interactions: Avoid alcohol consumption and smoking.

Dug-Disease Interactions: Tell your doctor if you have liver or kidney disease, heart problems, GI disorders, and eye problems before starting the treatment.

• ITRACONAZOLE
• CLARITHROMYCIN
• FLUCONAZOLE
• RITONAVIR
• WARFARIN
• VERAPAMIL
• DILTIAZEM
• CLOPIDOGREL

• Eat food rich in antioxidants such as berries, spinach, etc.
• Foods containing fibre help in better digestion. These include beans, peas, lentils, whole grains, nuts, and seeds.
• Physical activity helps strengthen muscles, reduces fatigue, helps in weight loss, and gives strength. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
• Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
• Getting adequate sleep as resting helps improve your health and mental ability and improves attention.
• De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
• Avoid smoking and alcohol consumption.
• Maintain a healthy weight.

• Using contraceptive pills while using Meqsel 0.5 mg Tablet to prevent pregnancy is advised.
• Thyroid function and adrenocorticotropic hormone levels will be monitored during treatment to avoid any life-threatening side effects.
• Seek medical attention immediately if you have swelling in your lower legs, fast heartbeats, or trouble breathing, as it may be a sign of a heart problem.

Metastatic Malignant Melanoma: Melanoma is a type of skin cancer in which the cancer cells grow in melanocytes. It is mainly caused by harmful UV radiation from the sun. Malignant melanoma is common in fair-skinned and freckled individuals. It results in mole formation, typically on the skin of the face.

Non-Small Cell Lung Cancer (NSCLC): It is the most common form of lung cancer, which occurs when cells that form the lining of the lung start growing uncontrollably. It is mostly seen in persons who smoke. Symptoms may include chest pain, weight loss, hoarseness, and difficulty breathing. Meqsel 0.5 mg Tablet is used in combination with pemetrexed and platinum chemotherapy as first-line treatment or in combination with carboplatin and either paclitaxel or paclitaxel protein-bound as first-line treatment of patients with metastatic squamous NSCLC.

Anaplastic Thyroid cancer: This condition occurs when the cancer cells grow abnormally in the thyroid gland. The thyroid gland is a butterfly-shaped organ present under the neck. This gland is useful in producing hormones responsible for the functioning of the body. Anaplastic thyroid cancer, also known as undifferentiated, is a rare type of thyroid carcinoma with an aggressive malignant tumor.