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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 9, 2024 | 10:52 AM IST

MDS-O 300 mg Tablet is used in treating Myelodysplastic syndrome, chronic myelomonocytic leukaemia, and acute myeloid leukaemia. It contains Azacitidine, a nucleoside metabolic inhibitor which works by preventing cancer cells from growing. It incorporates into the genetic material of the cells and interferes with the production of new DNA and RNA. This helps correct problems with the maturation and growth of young blood cells in the bone marrow, which causes myelodysplastic disorders.

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Manufacturer/Marketer

Adley Pharmaceuticals Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About MDS-O 300 mg Tablet

MDS-O 300 mg Tablet belongs to the group of anti-cancer medicines called demethylation agents indicated for continued treatment of acute myeloid leukaemia in adults who improved after chemotherapy but could not complete intensive curative therapy. Acute myeloid leukaemia is a type of cancer that forms in the blood-forming cells of the bone marrow.

MDS-O 300 mg Tablet contains Azacitidine, which works by interfering with the growth of cancer cells, which are eventually destroyed by the body. It helps the bone marrow in the production of normal blood cells and kills abnormal cells in the bone marrow.

In some cases, MDS-O 300 mg Tablet may cause side effects such as nausea, vomiting, diarrhoea, constipation, fatigue and abdominal pain. Most of these side effects may not require medical attention and resolve gradually over time. Do not be reluctant to talk with your doctor if any of the side effects persist or worsen.

Do not use MDS-O 300 mg Tablet if you are pregnant or breastfeeding. Consult a doctor immediately if you become pregnant during treatment with MDS-O 300 mg Tablet . This medicine is not recommended for children as safety and effectiveness have not been established. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Uses of MDS-O 300 mg Tablet

Treatment of Acute myeloid leukaemia

Medicinal Benefits

MDS-O 300 mg Tablet belongs to the group of anti-cancer medicines called demethylation agents indicated for continued treatment of adult patients with acute myeloid leukaemia who achieved first complete remission (all signs and symptoms of cancer have disappeared) or complete remission with incomplete blood count recovery following intensive induction chemotherapy and are not able to complete intensive curative therapy. MDS-O 300 mg Tablet contains Azacitidine, a nucleoside metabolic inhibitor which works by interfering with the growth of cancer cells, which are eventually destroyed by the body. It helps the bone marrow in the production of normal blood cells and kills abnormal cells in the bone marrow.

Directions for Use

Take MDS-O 300 mg Tablet with or without food. Swallow the medicine as a whole with water; do not crush or chew it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of MDS-O 300 mg Tablet

  • Nausea
  • Vomiting
  • Diarrhoea
  • Constipation
  • Dizziness
  • Fatigue
  • Abdominal pain
  • Decreased appetite
  • Arthralgia (joint pain)

Drug Warnings

Do not take MDS-O 300 mg Tablet if you are allergic to any of its components or if you are breastfeeding. Inform the doctor if you have liver or kidney problems. Seek medical attention if you experience symptoms of neutropenia/low white blood cells (fever or chills, feeling very tired or weak, body aches, and unusual headache) or thrombocytopenia/low platelet count (unusual bleeding or bruising). Consult the doctor if you are pregnant, plan to become pregnant, or if you plan to father a child.

Drug Interactions

Drug-Drug Interactions: No interactions found/established.

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: No interactions found/established.

Habit Forming

No

Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly as it helps maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include vegetables and fruits in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep; rest well.
  • Drink enough water and eat fibre-rich foods, vegetables and fruits.

Special Advise

  • If you are a female, you should take a pregnancy test prior to the start of the treatment. Use reliable contraception to prevent pregnancy during treatment and for 6 months after the last dose.
  • Male patients with partners of reproductive potential should use effective contraception during treatment and for 3 months after stopping the treatment.
  • If the powder from the medicine comes in contact with your skin, wash the area well with soap and water immediately.
  • If the powder from the medicine comes in contact with mucous membranes (eyes or mouth), flush the area with water immediately.

Disease/Condition Glossary

Acute myeloid leukaemia: Acute myeloid leukaemia, also called acute myelogenous leukaemia or acute nonlymphocytic leukaemia, is the cancer of blood and bone marrow with excess immature white blood cells. Symptoms include fever, recurrent infections, fatigue, and easy bruising.

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Alcohol

Consult your doctor

It is not known if alcohol affects MDS-O 300 mg Tablet . Please consult your doctor.

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Pregnancy

Unsafe

MDS-O 300 mg Tablet can harm the unborn baby. Avoid becoming pregnant during treatment with MDS-O 300 mg Tablet . Consult the doctor immediately if you become pregnant during treatment with MDS-O 300 mg Tablet .

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Breast Feeding

Unsafe

Avoid breastfeeding during treatment with MDS-O 300 mg Tablet and for one week after the last dose.

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Driving

Consult your doctor

It is unknown if MDS-O 300 mg Tablet affects your ability to drive. Drive only if you are alert.

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Liver

Caution

If you have a history of liver disease, inform your doctor before taking MDS-O 300 mg Tablet .

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Kidney

Caution

If you have a history of kidney disease, inform your doctor before taking MDS-O 300 mg Tablet .

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Children

Unsafe

MDS-O 300 mg Tablet is not recommended for children below 18 years as safety and effectiveness have not been established.

Country of origin

India

Manufacturer/Marketer address

2/236, KAMBRATH THAZAM, PULLALUR, KURUVATTOOR PO, NA KOZHIKODE Kozhikode Kerala 673012
Other Info - MDS0004

Author Details

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FAQs

MDS-O 300 mg Tablet is used to treat Acute myeloid leukaemia.
MDS-O 300 mg Tablet works by helping bone marrow in the production of normal blood cells and killing abnormal cells in the bone marrow.
MDS-O 300 mg Tablet may affect fertility in men and women. Consult the doctor if you have any concerns.
The doctor will prescribe anti-nausea medicine to help prevent nausea and vomiting during treatment with MDS-O 300 mg Tablet . Take the anti-nausea medicine 30 minutes before each dose of MDS-O 300 mg Tablet or as the doctor advises.
If you vomit after taking a dose MDS-O 300 mg Tablet , avoid taking another dose on the same day. Take the next dose at the regular time the next day. Talk to the doctor if you have any concerns.

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