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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Nov 10, 2024 | 7:19 PM IST
Markold Plus Syrup is used to treat the common cold and allergic symptoms like sneezing, watery eyes or itchy/watery nose and throat. It works by blocking the action of histamine, a substance responsible for causing allergic reactions. It helps relieve allergy symptoms. Also, it helps shrink the blood vessels in the nasal passage, reducing a stuffy nose. Some people may experience drowsiness, nausea, fatigue, dryness in the mouth, headache, and vomiting. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Consume Type

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Return Policy

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About Markold Plus Syrup

Markold Plus Syrup belongs to a category of  'cough and cold medications' primarily used to treat the common cold and allergic symptoms like sneezing, watery eyes or itchy/watery nose and throat. The common cold is a respiratory illness affecting the nose and throat, mostly caused by viruses known as 'rhinovirus'. The virus attacks the body through the mouth, nose, or eyes and spreads quickly through droplets in the air when a sick person sneezes, coughs or talks.

Markold Plus Syrup contains Cetirizine (antihistamine/antiallergic), Phenylephrine (decongestant) and Paracetamol (mild analgesic and antipyretic). Cetirizine belongs to the class of antihistamines (antiallergic drugs) that works by blocking the action of histamine, a substance responsible for causing allergic reactions. It helps relieve allergy symptoms such as sneezing, running nose, watery eyes, itching, swelling, congestion, or stiffness. Phenylephrine helps shrink the blood vessels in the nasal passage, reducing a stuffy nose. Paracetamol is an analgesic (relieves pain) and antipyretic (reduces fever) that works by inhibiting the production of certain chemical messengers in the brain known as 'prostaglandins' responsible for pain and fever.

Markold Plus Syrup should be taken as prescribed by the doctor. Your doctor will recommend how often you take Markold Plus Syrup based on your medical condition. Some people may experience drowsiness, nausea, fatigue, dryness in the mouth, headache, and vomiting. Everyone doesn't need to experience the above side effects. Most of these side effects of Markold Plus Syrup do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Inform your doctor if you are pregnant, planning for pregnancy or breastfeeding before starting Markold Plus Syrup. If you have high blood pressure (hypertension),  liver or kidney disease, or coronary artery disease (heart disease), avoid using Markold Plus Syrup as it may worsen your condition. Consumption of alcohol should be avoided as it may lead to excessive drowsiness and sleepiness. Do not take Markold Plus Syrup if you have taken an MAO inhibitor (anti-depressant medication like Isocarboxazid, Phenelzine, Selegiline and Tranylcypromine) in the last 14 days. Intake of more than 4 gm of paracetamol can damage your liver, so it is better to avoid the use of Markold Plus Syrup in severe liver damage. Cetirizine present in the Markold Plus Syrup can make you sleepy, so do not drive or operate heavy machinery after taking Markold Plus Syrup. Phenylephrine in Markold Plus Syrup should be used with caution in patients with occlusive vascular disease (nerve/artery blockage), including Raynaud's phenomenon (decreased blood flow to the fingers).

Uses of Markold Plus Syrup

Treatment of Common cold, Allergies (allergic rhinitis).

Medicinal Benefits

Markold Plus Syrup is primarily used to treat the common cold and allergy symptoms such as runny nose, blocked nose, sneezing, congestion, pain & fever. It is composed of three medicines, namely, Cetirizine (antihistamine), Phenylephrine (decongestant), and Paracetamol (mild analgesic and antipyretic). Cetirizine belongs to the class of antihistamines (anti-allergic drugs) that works by blocking the action of histamine, a substance responsible for causing allergic reactions. It helps relieve allergy symptoms such as sneezing, running nose, watery eyes, itching, swelling, congestion, or stiffness. Phenylephrine helps shrink the blood vessels in the nasal passage, reducing a stuffy nose. Paracetamol is a mild analgesic (relieves pain) and antipyretic (reduces fever) that works by inhibiting the production of certain chemical messengers in the brain known as 'prostaglandins' responsible for pain and fever.

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Markold Plus Syrup

  • Drowsiness
  • Nausea
  • Fatigue
  • Dryness in the mouth
  • Headache
  • Vomiting

Drug Warnings

Do not take Markold Plus Syrup if you are allergic to Markold Plus Syrup, anti-histamine (cetirizine), analgesics (paracetamol), a decongestant (phenylephrine), or any of its ingredients. Please inform your doctor if you are pregnant or breastfeeding before starting Markold Plus Syrup. If you have high blood pressure,  kidney or liver disease, or coronary artery disease, please do not take Markold Plus Syrup as it is known to interact. Also, inform your doctor about all other medications you have taken before starting Markold Plus Syrup. Do not stop taking Markold Plus Syrup even if you feel better without asking your doctor, as your symptoms may come back and even worsen your condition. Markold Plus Syrup may cause drowsiness and sleepiness, so it is advised not to drive a car or operate machinery. Consumption of alcohol should be avoided as it may lead to excessive drowsiness and sleepiness. Do not take Markold Plus Syrup if you have taken an MAO inhibitor (anti-depressant medication) in the past 14 days. Also, avoid tobacco consumption as it may worsen your condition further.

Drug Interactions

Drug-Drug Interactions: Markold Plus Syrup may interact with blood thinners (warfarin, aspirin), antibiotics (chloramphenicol), high cholesterol-lowering medicines (cholestyramine), anti-sickness drugs (domperidone, metoclopramide), anti-allergic drugs (diphenhydramine), drugs used to reduce acid in the stomach (pantoprazole), anti-depressants (isocarboxazid, rasagiline, linezolid, tranylcypromine).

Drug-Food Interactions: Avoid alcohol intake and tobacco consumption with Markold Plus Syrup as it may cause increased drowsiness, dizziness, and lack of concentration.

Drug-Disease Interactions: If you have high blood pressure, kidney or liver problems, coronary artery disease, or are receiving monoamine oxidase inhibitor (MAO) therapy, inform your doctor before taking Markold Plus Syrup.

Drug-Drug Interactions Checker List

  • WARFARIN
  • ASPIRIN
  • CHLORAMPHENICOL
  • CHOLESTYRAMINE
  • DOMPERIDONE
  • METOCLOPRAMIDE
  • DIPHENHYDRAMINE
  • PANTOPRAZOLE
  • ISOCARBOXAZID
  • RASAGILINE
  • LINEZOLID
  • TRANYLCYPROMINE

Habit Forming

No

Diet & Lifestyle Advise

  • ​​​​​​Wash your hands with soap and water regularly to prevent the spread of germs.

  • Eat plenty of foods rich in good bacteria, like yoghurt, to improve overall health. 

  • Drink plenty of fluids to avoid dehydration.

  • Gargle with salt water for relief from sore throat.

  • Avoid alcohol consumption with Markold Plus Syrup as it may cause tiredness, drowsiness, or lack of concentration.

Special Advise

  • Avoid alcohol consumption with Markold Plus Syrup as it may cause tiredness, drowsiness, or lack of concentration. 

  • Do not take Markold Plus Syrup if you have taken an MAO inhibitor (anti-depressant medication) in the past 14 days.

  • Please inform your doctor if you are pregnant or breastfeeding before starting Markold Plus Syrup as it contains caffeine, which can pass in the breast milk, which may have a stimulating effect on a breastfed child.

  • Smoking may further worsen your condition, so avoid tobacco consumption.

Disease/Condition Glossary

Common cold: The common cold is an infection caused by a virus known as 'rhinovirus' affecting your nose and throat (upper respiratory tract). Children younger than six years of age are at the most significant risk of colds, but healthy adults can also be affected to have 2-3 colds annually. In most cases, cold symptoms are recovered within a week or ten days. However, symptoms might last longer in people who smoke or are exposed to allergens like dust, pollutants, etc. Common cold symptoms might include stuffy or runny nose, sore throat, cough, congestion, mild body pain or a mild headache, sneezing, low-grade fever, and feeling unwell (malaise). In some cases, the discharge from your nose may become thicker and yellow or green, which does not indicate a bacterial infection. If you observe these symptoms, immediately contact your doctor.

Allergies: This is a condition that occurs when allergy-causing agents known as 'allergens' attacks our body, thereby causing symptoms like redness, stuffy nose, watery eyes, excess mucus formation, airways irritation, itchy and watery nasal passage/throat. During the allergic condition, our body secretes a lot of chemical messengers called 'histamines', which in turn cause all these allergic symptoms. Allergies can be caused due to various chemicals, air pollutants, dust, pollen grains of plants, pet danders, hairs and multiple medicines.

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Alcohol

Unsafe

Avoid consumption of alcohol with Markold Plus Syrup as it may increase drowsiness. Please consult a doctor before consuming alcohol with Markold Plus Syrup.

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Pregnancy

Caution

The safety of Markold Plus Syrup in pregnant women is unknown. Therefore, it is given to pregnant women only if the doctor thinks the benefits outweigh the risks.

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Breast Feeding

Caution

The safety of Markold Plus Syrup in breastfeeding mothers is unknown. Therefore, it is given to breastfeeding mothers only if the doctor thinks the benefits are greater than the risks.

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Driving

Unsafe

Markold Plus Syrup may cause drowsiness or tiredness in some people. Therefore, drive only if you are alert after taking Markold Plus Syrup.

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Liver

Caution

Take Markold Plus Syrup with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Markold Plus Syrup with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Caution

Markold Plus Syrup is not recommended for children below 12 years of age. However, please consult a doctor before giving Markold Plus Syrup to children.

Country of origin

India
Other Info - MA85057

Author Details

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FAQs

Markold Plus Syrup is used to treat the common cold and allergic symptoms like sneezing, watery eyes or itchy/watery nose and throat.
Markold Plus Syrup is composed of three medicines, namely Cetirizine (antihistamine), Phenylephrine (decongestant), and Paracetamol (analgesic and antipyretic). Cetirizine belongs to the class of antihistamines (anti-allergic drugs) that works by blocking the action of histamine, a substance responsible for causing allergic reactions. It helps relieve allergy symptoms such as sneezing, running nose, watery eyes, itching, swelling, congestion, or stiffness. Phenylephrine helps shrink the blood vessels in the nostrils and the passage and reduces stuffy noses. Paracetamol is an analgesic (relieves pain) and antipyretic (reduces fever) that works by inhibiting the production of certain chemical messengers in the brain known as 'prostaglandins' responsible for pain and fever.
Yes, Markold Plus Syrup contains cetirizine, which is an antihistamine that is known to cause dry mouth. Increase the intake of fluids to avoid excessive dry mouth caused due to Markold Plus Syrup as continued dryness can lead to dental disease (gum disease, fungal infection, tooth decay).
No, you are not recommended to take Markold Plus Syrup with warfarin as co-administration of these two medicines may increase bleeding risk more easily. However, if you notice blood in urine or stools, dizziness, unusual bleeding or bruising, vomiting, weakness, or headache, please consult a doctor immediately. If you are supposed to use these medicines together, you are advised to contact your doctor so that the dose may be adjusted appropriately to use safely.
It is not recommended to take Markold Plus Syrup along with any anti-depressant medication as it contains phenylephrine, which is known to be contra-indicated with anti-depressant medications, especially MAO inhibitors. Also, Markold Plus Syrup should be taken at least 15 days after your last dose of anti-depressants.
Yes, the Markold Plus Syrup is known to cause nausea or vomiting. In case you are experiencing excessive nausea while consuming Markold Plus Syrup, speak with your doctor immediately.
Yes, the Markold Plus Syrup may cause drowsiness. It is not necessary for everyone taking Markold Plus Syrup to experience this side effect. Therefore, avoid driving if you feel drowsy after taking Markold Plus Syrup.
Store Markold Plus Syrup at room temperature, in a dry place. Keep it out of sight and reach of children.
Markold Plus Syrup may cause side effects like drowsiness, nausea, fatigue, dryness in the mouth, headache, and vomiting. Most of these side effects of Markold Plus Syrup do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
Please consult the doctor if you are breastfeeding. The safety of Markold Plus Syrup in breastfeeding mothers is unknown. Therefore, it is given to breastfeeding mothers only if the doctor thinks the benefits are greater than the risks.
Markold Plus Syrup is contraindicated in people who are allergic to any of the components in Markold Plus Syrup. Let the doctor know if you have heart problems, stomach ulcers or thyroid problems.
No, taking a higher than the recommended dose of Markold Plus Syrup will not be more effective but may cause unpleasant side effects. Take Markold Plus Syrup as per the dose advised by the doctor.
Serious side effects associated with Markold Plus Syrup are allergic reactions, mouth ulcers, breathing problems, irregular heartbeat, or unexplained bleeding. Consult the doctor if you experience any of these side effects.

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