Makofz Ace Syrup belongs to the class of medicines called ‘expectorants’ primarily used to treat cough associated with mucus, called chesty cough. Coughing (dry or productive) is a body’s way of clearing irritants (like allergens, mucus, or smoke) from airways and preventing infection. There are two types of coughs, namely: Dry cough and chesty cough. A dry cough is tickly and doesn’t produce any vicious or thick mucus, while a chesty cough (wet cough) means mucous or sputum is produced to help clear your airways.

Makofz Ace Syrup is a combination of three medicines: Acebrophylline, Guaifenesin, and Terbutaline. Acebrophylline is a mucolytic agent (cough/sputum thinner) that works by thinning and loosening phlegm (mucus) in the lungs, windpipe, and nose. Guaifenesin belongs to the class of expectorants that works by increasing the volume of fluid in the airways, reduces the stickiness of mucus, and helps to remove it from airways. Terbutaline belongs to the class of bronchodilators that relaxes muscles and widens the airways.

You should take this medicine as prescribed by your doctor. The common side-effects of Makofz Ace Syrup are stomach pain or discomfort, vomiting, constipation, heartburn, loss of appetite, drowsiness, dizziness, skin rash, itching, nervousness, tremors, and headache. Most of these side effects of Makofz Ace Syrup do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor immediately.

Do not take Makofz Ace Syrup if you are allergic to Acebrophylline, Guaifenesin, Terbutaline, or any other contents of it. Before taking Makofz Ace Syrup, inform your doctor if you have diabetes, fits, hypotension (low blood pressure), overactive thyroid, hypokalemia (low potassium levels in the blood), stomach ulcers, phenylketonuria (a birth defect that causes accumulation of amino acid, phenylalanine in the body), arrhythmias (abnormal heart rhythms), and kidney, liver or heart problems. Also, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Makofz Ace Syrup is a combination of three medicines: Acebrophylline, Guaifenesin, and Terbutaline. Acebrophylline belongs to the class of mucolytic agents (cough/sputum thinner) that works by thinning and loosening phlegm (mucus) in the lungs, windpipe, and nose. Guaifenesin belongs to the class of expectorants that works by increasing the volume of fluid in the airways, reduces the stickiness of mucus, and helps to remove it from airways. Terbutaline belongs to the class of bronchodilators that relaxes muscles and widens the airways. Together, Makofz Ace Syrup helps to cough out the phlegm easily and clear the airways making breathing easier.

• Stomach pain or discomfort
• Vomiting
• Constipation
• Heartburn
• Loss of appetite
• Drowsiness
• Dizziness 
• Skin rash 
• Itching 
• Nervousness
• Tremors
• Headache

Makofz Ace Syrup should be used with caution in patients with heart diseases, liver problems, kidney diseases, electrolyte disturbances, thyroid disorders, and arrhythmias (abnormal heart rhythms). Makofz Ace Syrup should be used with caution in patients with fits, as it may increase the recurrence of fits. Makofz Ace Syrup may raise blood glucose levels, so this medicine should be used with caution in patients with diabetes. Makofz Ace Syrup should be used with caution in elderly patients as they are more prone to side effects such as dizziness and drowsiness.

Drug-Drug Interactions: Makofz Ace Syrup may interact with water pill (furosemide), medicines used to treat gout (allopurinol), antacid (cimetidine), antibiotics (ciprofloxacin, erythromycin, amoxicillin, and doxycycline), a nasal decongestant (phenylephrine), a medication used to treat slow heart rate (isoproterenol), a medication used to treat heart failure (dobutamine), corticosteroids, oral contraceptives, drugs used to treat high blood pressure (diltiazem and verapamil), and antihelmintic (thiabendazole).

Drug-Food Interactions: Avoid caffeinated and cold drinks as these may worsen the cough.

Drug-Disease Interactions: Makofz Ace Syrup should be used with caution in patients with diabetes, seizures (fits), hypotension (low blood pressure), overactive thyroid, stomach ulcers, phenylketonuria (a birth defect that causes accumulation of amino acid, phenylalanine in the body), arrhythmias (abnormal heart rhythms), and kidney, liver or heart problems.

• FUROSEMIDE
• ALLOPURINOL
• CIMETIDINE
• CIPROFLOXACIN
• ERYTHROMYCIN
• AMOXICILLIN
• DOXYCYCLINE
• PHENYLEPHRINE
• ISOPROTERENOL
• DOBUTAMINE
• DILTIAZEM
• VERAPAMIL
• THIABENDAZOLE

• Avoid dairy products such as milk as they may increase mucus production. Also, avoid processed or refined foods to have relief from cough. Instead, replace baked foods, fried foods, white bread, white pasta, French fries, sugary desserts, and chips with green leafy vegetables.
• Drink plenty of fluids to avoid dry throat while you have a cough and loosen mucus.
• Avoid citrus fruits as they may worsen the cough. Eat fruits rich in water content such as pears, watermelon, peaches, and pineapples. Honey can also help to reduce cough.
• Use a cool-mist humidifier as it may help ease coughing.

• Regular monitoring of blood sugars is advised as Makofz Ace Syrup may cause fluctuation of blood sugars.

Chesty Cough: Coughing is the body’s way of clearing irritants (like allergens, mucus, or smoke) from the airways and preventing infection. Coughs may be dry or productive. A productive cough (wet cough) brings up sputum (phlegm, mucus, and other matter) from the lungs. Cough is commonly caused as a response to allergy or viral infection but coughing up mucus is possibly an indication of infection in the respiratory tract. If you are coughing thick, solid white mucus, it indicates you may have a bacterial infection in the airways. If the mucus is clear or light-coloured, it indicates you may have allergies or minor infections in the respiratory tract, and yellow or green mucus indicates a respiratory infection.