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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Last Updated Nov 23, 2024 | 4:49 PM IST
Macrozide 1200mg Tablet is used to treat and prevent tuberculosis. It contains Pyrazinamide which converts a special enzyme to an active form that inhibits the synthesis of fatty acids; this disrupts the cell membrane and disables energy production necessary for the survival of the TB bacteria. It may cause common side effects such as muscle/joint pain, nausea, vomiting and loss of appetite. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Manufacturer/Marketer

Macleods Pharmaceuticals Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Macrozide 1200mg Tablet

Macrozide 1200mg Tablet is used to treat and prevent tuberculosis. Tuberculosis is an infectious disease that mainly affects the lungs, but it can also spread to other body parts such as kidneys, brain, spine and bone marrow. Macrozide 1200mg Tablet does not work against infections caused by the virus, such as the common cold and flu.

Macrozide 1200mg Tablet contains 'Pyrazinamide'. Pyrazinamide is a chemically synthesised bacteriocidal antibiotic. It converts a special enzyme to an active form that inhibits the synthesis of fatty acids; this disrupts the cell membrane and disables energy production necessary for the survival of the TB bacteria.

Your doctor will decide the dose and duration based on the severity of your disease. Common side effects of Macrozide 1200mg Tablet include muscle/joint pain, nausea, vomiting and loss of appetite. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Let your doctor know if you use any prescription and non-prescription medications you are taking, including other vitamins, before starting Macrozide 1200mg Tablet. Please tell your doctor if you are allergic to Macrozide 1200mg Tablet or its components. Inform your doctor beforehand if you have a history of liver or kidney diseases, diabetes, gout, high uric acid level in the blood, alcohol use and are undergoing dialysis. It is essential to let your doctor know if you are pregnant, planning to conceive or are a breastfeeding mother. Avoid consuming alcohol along with Macrozide 1200mg Tablet as it might lead to liver problems.

Uses of Macrozide 1200mg Tablet

Treatment of Tuberculosis (TB).

Medicinal Benefits

Macrozide 1200mg Tablet contains 'Pyrazinamide', which is used to treat and prevent tuberculosis. Pyrazinamide is a chemically synthesised bacteriocidal antibiotic. It converts a special enzyme to an active form that inhibits the synthesis of fatty acids; this disrupts the cell membrane and disables energy production necessary to survive the TB bacteria. It is usually given in alone or combined with other antitubercular agents to treat tuberculosis.

Directions for Use

Swallow Macrozide 1200mg Tablet as a whole with water; do not crush, break or chew it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Macrozide 1200mg Tablet

  • Muscle/joint pain

  • Nausea

  • Vomiting

  • Loss of appetite

  • Hepatitis, liver dysfunction

Drug Warnings

Brief your medical history to the doctor if you have any liver or kidney diseases, diabetes, gout, high uric acid level in the blood, lactose intolerance, alcohol use and are undergoing dialysis treatment before starting Macrozide 1200mg Tablet. Let your doctor know if you are undergoing any vaccinations with live bacterial vaccines (like typhoid vaccine) since Macrozide 1200mg Tablet may affect vaccine's activity. Please consult your doctor know if you are pregnant, planning to conceive or are a breastfeeding mother before starting Macrozide 1200mg Tablet. Avoid consuming alcohol along with Macrozide 1200mg Tablet as it might lead to liver problems. Store Macrozide 1200mg Tablet below 25°C away from direct sunlight.

Drug Interactions

Drug-Drug Interaction: Macrozide 1200mg Tablet may interact with gout medicine (probenecid, sulfinpyrazone) and oral contraceptives.

Drug-Food Interaction: Do not consume alcohol while taking Macrozide 1200mg Tablet as it could lead to increased liver damage.

Drug-Disease Interaction: Before using Macrozide 1200mg Tablet, let your doctor know if you have any liver or kidney diseases, diabetes, gout, high uric acid level in the blood, lactose intolerance, alcohol use and undergoing dialysis treatment.

Drug-Drug Interactions Checker List

  • PROBENECID
  • SULFINPYRAZONE

Habit Forming

No

Diet & Lifestyle Advise

  • Pineapple juice might help soothe the symptoms of cough and cold. It also has anti-inflammatory and mucolytic properties.

  • Foods rich in vitamin C, such as kiwi, broccoli and bell pepper, help improve the immune system.

  • Avoid processed and fried foods.

  • Warm ginger tea or warm soup can help in providing relief from the cough.

  • Avoid foods and drinks, such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine and beer.

  • Quit smoking and avoid alcohol consumption.

Special Advise

  • Let your doctor know that you are taking Macrozide 1200mg Tablet if you are undergoing any medical tests.

  • Your doctor may advise liver enzymes and uric acid levels tests before you start treatment to make sure you can safely take Macrozide 1200mg Tablet.

  • It is advised to undergo liver functioning tests to keep a check on your liver function.

  • Use a reliable contraceptive method (such as condoms or a diaphragm) to prevent pregnancy while you are taking Macrozide 1200mg Tablet as it may make hormonal contraceptives such as the pill less effective.

Disease/Condition Glossary

Tuberculosis (TB): Tuberculosis is an infectious disease that affects the lungs, but it could also spread to other body parts such as kidneys, brain, spine and bone marrow. Tuberculosis is caused by a bacteria named Mycobacterium tuberculosis. It is a contagious disease which can spread to others through small droplets released into the air by a person suffering from tuberculosis. Symptoms include a cough that lasts for a few weeks, pain while coughing or normal breathing, unexplained fatigue, fever, night sweats, and loss of appetite and weight. People who smoke or consume alcohol, and people diagnosed with HIV and immune system problems are more likely at risk of developing active TB.

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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Macrozide 1200mg Tablet. Alcohol intake, along with Macrozide 1200mg Tablet, may cause increased liver damage. Please consult your doctor for more information.

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Pregnancy

Caution

Macrozide 1200mg Tablet should be used with caution during pregnancy. Please consult your doctor before taking Macrozide 1200mg Tablet if you are pregnant or planning to conceive.

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Breast Feeding

Caution

Macrozide 1200mg Tablet is not recommended for use during breastfeeding since it is excreted into the breast milk and may harm a nursing baby. Please consult your doctor if you are a breastfeeding mother.

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Driving

Caution

It is not known if Macrozide 1200mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to drive or operate machinery.

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Liver

Caution

Macrozide 1200mg Tablet is not recommended in patients with severe liver damage. Please consult your doctor since Macrozide 1200mg Tablet should be used with caution in patients with liver impairment/liver disease. Regular monitoring of the liver with liver function tests is also advised.

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Kidney

Caution

Please consult your doctor since Macrozide 1200mg Tablet should be used with caution in patients with kidney impairment/kidney disease. Your doctor may adjust the dosage in case of renal dysfunction.

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Children

Caution

Macrozide 1200mg Tablet is recommended in children below 12 years of age only after doctor's advice.

Country of origin

India

Manufacturer/Marketer address

Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, INDIA.
Other Info - MAC0071

Author Details

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FAQs

Macrozide 1200mg Tablet is used to treat and prevent tuberculosis.
Macrozide 1200mg Tablet contains 'Pyrazinamide.' It is bactericidal and works by stopping the growth of Mycobacterium tuberculosis, a bacteria that causes tuberculosis.
Macrozide 1200mg Tablet is not recommended for use in the medical history of liver or kidney diseases, diabetes, gout, high uric acid level in the blood, alcohol use and undergoing dialysis treatment. Please let your doctor know if you have any other medical problems before starting Macrozide 1200mg Tablet.
Macrozide 1200mg Tablet can affect the live vaccines like typhoid vaccine and decrease its effectiveness. Please consult a doctor before you start Macrozide 1200mg Tablet if you are undergoing any vaccinations.
It is advised to take Macrozide 1200mg Tablet 30 minutes before food or 2 hours after food. Please consult your doctor for more information.
Macrozide 1200mg Tablet gets converted in the body to Pyrazinoic acid that blocks the excretion of urates (salt form of uric acid) by the kidneys. Increased blood levels of uric acid (hyperuricemia) causes pain, swelling, redness and stiffness in joints (gout). Hence, Macrozide 1200mg Tablet should be avoided if you have a history of gout.
Macrozide 1200mg Tablet is an antibiotic that belongs to the group of anti-tuberculosis (TB) drugs. It is used for the treatment of tuberculosis which is an infectious disease that mainly affects lungs but can also impact other parts of the body.
Yes, Macrozide 1200mg Tablet is bactericidal. It works by inhibiting the growth of Mycobacterium tuberculosis, the bacteria that is responsible for causing tuberculosis.
Macrozide 1200mg Tablet causes hyperuricemia and gout by inhibiting the renal excretion of uric acid, which can lead to the precipitation or worsening of gout. It should be used with caution in individuals with hyperuricemia or a history of gout.
The side effects of Macrozide 1200mg Tablet include nausea, vomiting, muscle/joint pain, nausea and loss of appetite. Consult the doctor if any of these symptoms persist or worsen.

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