Lorbriqua 25 mg Tablet belongs to the group of medicines that inhibit an enzyme called anaplastic lymphoma kinase (ALK). It is used to treat adults with advanced stages of lung cancer called non-small cell lung cancer (NSCLC). Non-small cell lung cancer is a disease in which malignant (cancer) cells form in the lung tissues. There are several types of non-small cell lung cancer. Smoking is the major risk factor for non-small cell lung cancer.

Lorbriqua 25 mg Tablet contains the active substance Lorlatinib, a medicine used to treat adults with advanced stages of a form of lung cancer called non-small cell lung cancer (NSCLC). It works by inhibiting a type of enzyme called tyrosine kinase and triggers the death of cancer cells in patients with alterations in genes for ALK. Lorbriqua 25 mg Tablet is only given to patients whose disease is due to an alteration in the gene for ALK tyrosine kinase.

Always use this medicine as your doctor has told you or per the package leaflet. You must keep to your doctor's instructions to get the maximum benefit. In some cases, you may experience common side effects such as diarrhoea, constipation, joint pain, weight gain, headache, rash, and muscle pain. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Consult your doctor before taking Lorbriqua 25 mg Tablet if you are pregnant or breastfeeding. Lorbriqua 25 mg Tablet may cause tiredness and dizziness, so drive with caution. Avoid consuming alcohol with Lorbriqua 25 mg Tablet as it could lead to increased dizziness. Lorbriqua 25 mg Tablet is not recommended for children below 18 years as safety and effectiveness have not been established. Lorbriqua 25 mg Tablet is listed as pregnancy category D. Because Lorbriqua 25 mg Tablet can cause harm to the fetus, women of childbearing potential should be advised to avoid becoming pregnant while receiving treatment with Lorbriqua 25 mg Tablet . Consult your doctor if you are breastfeeding; your doctor will decide whether Lorbriqua 25 mg Tablet can be taken by breastfeeding mothers or not. Keep your doctor informed about your health condition and medicines to rule out any side effects. Lorbriqua 25 mg Tablet may affect male fertility. Talk to your doctor about fertility preservation before taking Lorbriqua 25 mg Tablet .

Lorbriqua 25 mg Tablet contains the active substance Lorlatinib, a medicine used to treat adults with advanced stages of a form of lung cancer called non-small cell lung cancer (NSCLC). Lorbriqua 25 mg Tablet is only given to patients whose disease is due to an alteration in the gene for ALK tyrosine kinase. It works by inhibiting a type of enzyme called tyrosine kinase and triggers the death of cancer cells in patients with alterations in genes for ALK.

• Increase in cholesterol and triglycerides
• Limb or skin swelling
• Double vision
• Pain
• Numbness
• Unusual sensations such as burning or pins and needles, difficulty walking, or difficulty with usual activities of daily
• Increased level of enzymes called lipase and/or amylase
• Anaemia
• Diarrhoea
• Constipation
• Pain in your joints
• Weight gain
• Headache
• Rash
• Muscle pain

Consult your doctor before taking Lorbriqua 25 mg Tablet if you are pregnant or breastfeeding. Lorbriqua 25 mg Tablet may cause tiredness and dizziness, so drive with caution. Avoid consuming alcohol with Lorbriqua 25 mg Tablet as it could lead to increased dizziness. Lorbriqua 25 mg Tablet is not recommended for children below 18 years as safety and effectiveness have not been established. Lorbriqua 25 mg Tablet is listed as pregnancy category D. Because Lorbriqua 25 mg Tablet can cause harm to the fetus, women of childbearing potential should be advised to avoid becoming pregnant while receiving treatment with Lorbriqua 25 mg Tablet . Consult your doctor if you are breastfeeding; your doctor will decide whether the Lorbriqua 25 mg Tablet can be taken by breastfeeding mothers or not. Keep your doctor informed about your health condition and medicines to rule out any side effects. Lorbriqua 25 mg Tablet may affect male fertility. Talk to your doctor about fertility preservation before taking Lorbriqua 25 mg Tablet .

Drug-Drug Interactions: Lorbriqua 25 mg Tablet may interact with various medications, including medicines used to treat fungal infections (e.g. Ketoconazole, Itraconazole), medications used to treat bacterial infections/CYP3A4 inhibitors (e.g. Erythromycin), a drug used to treat irregular heartbeat and other heart problems. (e.g. Quinidine), medications used to treat severe pain (e.g. Alfentanil and Fentanyl), medicines used in organ transplantation to prevent organ rejection (e.g. Ciclosporin, Sirolimus, and Tacrolimus), medicines used to treat AIDS/HIV (e.g. Efavirenz, Cobicistat), medications used to treat migraine headaches (e.g. Dihydroergotamine, Ergotamine ), a drug used to treat depression or to help people quit smoking (e.g. Buproprion), and medication used to treat hepatitis C (e.g. Boceprevir).

Drug-Food Interactions: You must not drink grapefruit juice or eat grapefruit while on treatment with Lorbriqua 25 mg Tablet as they may change the amount of Lorbriqua 25 mg Tablet in your body.

Drug-Disease Interactions: Lorbriqua 25 mg Tablet should be used with caution in patients with liver disorders, kidney disorders, central nervous system (CNS) and heart disorders.

• KETOCONAZOLE
• ITRACONAZOLE
• ERYTHROMYCIN
• QUINIDINE
• ALFENTANIL
• FENTANYL
• CICLOSPORIN
• SIROLIMUS
• TACROLIMUS
• EFAVIRENZ
• COBICISTAT
• BUPRENORPHINE
• DIHYDROERGOTAMINE
• ERGOTAMINE
• BUPROPION
• BOCEPREVIR

• Watch out for triggers that worsen the cough, such as smoke, foods, air-conditioning, high altitude, etc.
• Exercise moderately. Eat healthily.
• Follow pulmonary rehabilitation program. It includes exercise, disease education, and group therapy.
• Quit smoking and alcohol.
• Get ample rest.
• Include green leafy vegetables, sweet potatoes, broccoli, tomatoes, carrots, mangoes, citrus fruits, berries, and cocoa.
• Lean proteins such as fish, meat, and poultry are the best.
• Hydration is important. Drink plenty of water, herbal tea, and vegetable and fruit juices.
• Avoid processed and refined foods.

You will have blood tests before you start treatment and during your treatment. These tests check the level of cholesterol, triglycerides and the enzymes amylase or lipase in your blood before you start treatment with Lorbriqua 25 mg Tablet and regularly during treatment. You will have blood tests before you start treatment and during your treatment. These tests check the level of cholesterol, triglycerides and the enzymes amylase or lipase in your blood before you start treatment with Lorbriqua 25 mg Tablet and regularly during treatment.

Non-small cell lung cancer (NSCLC): Non-small cell lung cancer (NSCLC) is a disease in which malignant (cancer) cells form in the lung tissues. There are several types of non-small cell lung cancer. Smoking is the major risk factor for non-small cell lung cancer.