Linigem Injection

Linigem Injection belongs to the class of 'anti-emetic' drugs, primarily used to treat nausea and vomiting caused by medical treatments after surgery or chemotherapy or radiation treatment for cancer. Nausea is defined as stomach discomfort and the sensation of an urge to vomit. Vomiting is the forcible voluntary or involuntary emptying of contents of the stomach through the mouth.

Linigem Injection contains an anti-emetic (eases vomiting symptoms) medicine, 'Granisetron', that belongs to the class of 5-HT3 receptor antagonists (also called serotonin receptor antagonists or serotonin blockers). It works by blocking the brain's serotonin (chemical messenger) activity that triggers nausea and vomiting during cancer treatment (chemotherapy or radiation therapy) or after surgery.

Linigem Injection will be administered by a healthcare professional; do not self-administer. Your doctor will decide the dose and duration based on the severity of your medical condition. Common side effects of Linigem Injection include diarrhoea, constipation, stomach pain, weakness, headache, fever, drowsiness, trouble sleeping, pain, redness, and swelling at the injection site. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

If you use other prescription or non-prescription medicines, inform your doctor before using Linigem Injection. Let your doctor know if you have any liver, kidney or heart diseases, stomach/intestinal problems, allergic reactions, and low levels of potassium and magnesium in the blood before starting Linigem Injection. This medicine may make you dizzy or drowsy; hence avoid driving or operating machinery if you are not mentally alert. Consult your doctor before using Linigem Injection if you are pregnant, planning for pregnancy or breastfeeding. Avoid consuming alcohol while being treated with Linigem Injection as it could lead to unwanted side effects. 

Linigem Injection contains an anti-emetic medicine, 'Granisetron', that treats nausea and vomiting caused due to cancer treatment (chemotherapy or radiation therapy) or after surgery. Granisetron belongs to the class of 5-HT3 receptor antagonists (also called serotonin receptor antagonists or serotonin blockers). When the cells lining the gastrointestinal tract are damaged by chemotherapy or radiation therapy, they release a natural substance called serotonin (5HT3, 5-hydroxytryptamine). This serotonin binds to serotonin receptors on nerves that induces nausea and vomiting. Linigem Injection works by blocking the brain's serotonin activity and preventing postoperative nausea and vomiting. 

• Diarrhoea
• Constipation
• Stomach pain
• Weakness
• Headache
• Fever
• Dizziness
• Drowsiness
• Trouble sleeping
• Pain, redness, and swelling at the injection site

Seeking medical advice if you use prescription or non-prescription medicines while being treated with Linigem Injection is suggested. Inform your doctor about a history of stomach/intestinal problems, heart diseases, electrolyte imbalance (potassium, sodium or calcium), and liver or kidney diseases before starting Linigem Injection. Please consult your doctor if you are pregnant or breastfeeding if the doctor advised you Linigem Injection. This medicine may make you feel dizzy, so drive or operate machinery only if you are alert. Avoid consuming alcohol during the course, as it could lead to increased dizziness. Linigem Injection is not recommended in children below two years of age.

Drug-Drug Interaction: Linigem Injection may interact with antidepressants (fluoxetine, duloxetine), heart-related drugs (amiodarone, sotalol), antipsychotic drugs (pimozide), antibiotics (erythromycin), and St. John's wort, a plant-based medicine used for depression and mood disorders.

Drug-Food Interaction: Alcohol may increase dizziness when taken with Linigem Injection.

Drug-Disease Interaction: Before using Linigem Injection, let your doctor know if you have any stomach/intestinal problems like stomach ache, wind, feeling or being sick, difficulty passing stools, electrolyte imbalance (potassium, sodium or calcium), heart problems, liver or kidney diseases.

• FLUOXETINE
• DULOXETINE
• AMIODARONE
• SOTALOL
• PIMOZIDE
• ERYTHROMYCIN

• Avoid chocolates, junk food, cheese, processed food, alcohol, and smoking. 
• You can try increasing your mindfulness by doing yoga, meditation, mindfulness-based cognitive therapy, and stress reduction techniques.
• Drink enough water to stay hydrated and limit or avoid alcohol and caffeine.
• Include a diet rich in whole grains, vegetables, and fruits.
• You can include antioxidants in your daily diet, like ashwagandha, omega-3 fatty acids, green tea, and lemon.
• Try to spend time with your friends and family. Having a strong social network may help you lower your risk of anxiety.

• Let your doctor know you are taking Linigem Injection if you undergo medical tests.
• Heart function monitoring with an ECG or EKG (electrocardiogram) is recommended in heart patients since Linigem Injection may cause irregular heartbeat and QT prolongation (heart muscle takes longer than normal to recharge between beats).

Nausea is defined as stomach discomfort and the sensation of an urge to vomit. It is a precursor to vomiting. It is not a painful symptom but can cause discomfort in the chest, upper abdomen, or back of the throat. Nausea can be triggered by various factors like motion from a car and plane, taking pills on an empty stomach, eating too much or too little, and drinking excessive amounts of alcohol. 

Vomiting or throwing up is the forcible voluntary or involuntary emptying of contents of the stomach through the mouth. Vomiting can also occur without any underlying diseases like pregnancy, hangovers, overeating, and motion sickness. Nausea or vomiting may be triggered by many factors, including food poisoning, gastritis (inflammation of the stomach lining), an ulcer, or bulimia (eating disorder).