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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Jan 1, 2025 | 2:47 PM IST
Levosimed 12.5mg Injection is used to treat acute heart failure in hospitalised patients. It contains levosimendan which works by relaxing and widening the smooth muscles of the heart, allowing blood and oxygen to flow easily throughout the body. In some cases, this medicine may cause side effects such as headache, low blood pressure, and nausea. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

LEVOSIMENDAN-12.5MG

Manufacturer/Marketer :

Samarth Life Sciences Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

About Levosimed 12.5mg Injection

Levosimed 12.5mg Injection belongs to the group of medications called 'calcium sensitizer' primarily used to treat hospitalized patients with acute heart failure. Heart failure can occur when your heart cannot pump blood sufficiently required to the remainder of the body. A heart attack is the blockage of blood flow to the heart muscle. The blockage is most often a build-up of fat, cholesterol, and other substances, which form a plaque in the arteries that feed the heart (coronary arteries).  Heart attack and brain stroke can occur simultaneously as the brain's stroke blood supply gets interrupted, causing a part of the brain to die.

Levosimed 12.5mg Injection contains 'levosimendan', which works by increasing the heart's sensitivity to calcium ion (Ca) without increasing the amount of calcium present in the heart's muscles cells. Levosimed 12.5mg Injection widens up the heart's blood vessels (coronary artery) and, in turn, relaxes the smooth muscles of the heart so that blood and oxygen can flow easily to the whole body. 

The most common side effects of Levosimed 12.5mg Injection are headache, low blood pressure, and nausea (stomach discomfort). Most of these side effects of Levosimed 12.5mg Injection do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Levosimed 12.5mg Injection should not be given to the patients with low blood pressure (hypotension), dehydration, low blood count, chest pain (angina), or have abnormal heart rhythm. Pregnant or lactating women should consult a doctor before administration of Levosimed 12.5mg Injection. This medicine should not be given to children and adolescents under 18 years of age. 

Uses of Levosimed 12.5mg Injection

Treatment of Heart failure

Medicinal Benefits

Levosimed 12.5mg Injection is a calcium sensitizer that enhances the heart's pumping forces and allows blood vessels to relax. Improvement of the cardiac function by Levosimed 12.5mg Injection helps reduce the congestion in your lungs and enhances blood and oxygen delivery to the organs. Thus, treatment with Levosimed 12.5mg Injection relieves the shortness of breath from severe heart failure.

Side Effects of Levosimed 12.5mg Injection

  • Headache
  • Low blood pressure (hypotension)
  • Nausea (feeling sick)
  • Tachycardia (fast heartbeat)

Directions for Use

Levosimed 12.5mg Injection will be administered by a healthcare professional; do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not use Levosimed 12.5mg Injection if you are allergic to any of its contents. Do not take Levosimed 12.5mg Injection if you are pregnant, think you may be pregnant, or trying for pregnancy. Consult your doctor before taking Levosimed 12.5mg Injection if you are breastfeeding. Try not to stop taking this medicine of your own as stopping Levosimed 12.5mg Injection abruptly may worsen your condition and increase your risk of a future heart attack. Levosimed 12.5mg Injection should not be given to the patients with low blood pressure (hypotension), dehydration, low blood count, chest pain (angina), or have abnormal heart rhythm. This medicine should not be given to children and adolescents under 18 years of age. Levosimed 12.5mg Injection should not be given into the same vein as other medicines except for heart-related medicines like frusemide, digoxin or glyceryl trinitrate. This is because if you have been given other heart-related medicines through your veins, your blood pressure might drop if you are given Levosimed 12.5mg Injection. 

Therapeutic Class

CARDIOVASCULAR AGENTS

Diet & Lifestyle Advise

  • Follow a cholesterol-lowering diet.
  • Consume a low-salt and a low-fat diet.
  • Exercise regularly. It helps in maintaining proper weight and lowers cholesterol.
  • Limit salt and sugar intake.
  • Avoid smoking and alcohol consumption. 
  • Choose healthy fats and cut down on trans-fat.
  • Include omega-3 fatty acids, fibre-rich food, fruits, and vegetables.
  • Get active by doing any physical activity such as swimming, brisk walking, or jogging. Take the stairs instead of elevators/lifts.

Habit Forming

No

How Levosimed 12.5mg Injection Works

Levosimed 12.5mg Injection contains 'levosimendan', which works by increasing the heart's sensitivity to calcium ion (Ca) without increasing the amount of calcium present in the heart's muscles cells. Levosimed 12.5mg Injection widens up the heart's blood vessels (coronary artery) and, in turn, relaxes the smooth muscles of the heart so that blood and oxygen can flow easily to the whole body.

What if I have taken an overdose of Levosimed 12.5mg Injection

Take Levosimed 12.5mg Injection only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Levosimed 12.5mg Injection as it may cause increased dizziness.

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Pregnancy

Unsafe

Do not take Levosimed 12.5mg Injection if you are pregnant, think you may be pregnant or if you are trying for pregnancy. Consult a doctor immediately if you become pregnant while taking Levosimed 12.5mg Injection.

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Breast Feeding

Caution

It is not recommended to take Levosimed 12.5mg Injection if you are breastfeeding. Consult your doctor before taking Levosimed 12.5mg Injection; your doctor will decide whether Levosimed 12.5mg Injection can be taken by breastfeeding mothers or not.

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Driving

Caution

Levosimed 12.5mg Injection may cause dizziness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Levosimed 12.5mg Injection is not recommended for children as the safety and effectiveness have not been established.

Country of origin

India
Other Info - LE44408

Author Details

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Levosimed 12.5mg Injection Substitute

Substitutes safety advice
  • Simenda 12.5mg Injection 5 ml

    102.04per tablet
  • Carmendan Injection

    895.50per tablet
  • Limandan 12.5mg Injection

    359.10per tablet

FAQs

Levosimed 12.5mg Injection is used to treat heart failure.
Levosimed 12.5mg Injection is composed of levosimendan that belongs to the therapeutic class of drugs called calcium sensitizers used to increase the heart sensitivity to calcium without increasing the amount of calcium present in the heart cells. This medication widens up the blood vessels and relaxes the smooth muscles of the heart so that blood can flow easily to the whole body. Thus, treatment with Levosimed 12.5mg Injection relieves the shortness of breath from severe heart failure.
Do not discontinue Levosimed 12.5mg Injection without consulting your doctor as it could increase the risk of a heart attack. To treat your condition effectually continue taking Levosimed 12.5mg Injection for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Levosimed 12.5mg Injection.
Constipation could be a side-effect of Levosimed 12.5mg Injection. Drink plenty of fluids and eat fibre rich food if you experience constipation. Consult your doctor if you have severe constipation.
Orthostatic hypotension could be a side-effect of Levosimed 12.5mg Injection. Orthostatic hypotension is a sudden lowering in blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking, instead lie down and get up slowly only when you feel better. People taking Levosimed 12.5mg Injection are advised to regularly monitor their blood pressure levels to avoid such unpleasant events.
Heart failure happen heart become unable to pump blood in the whole body as it should. Certain conditions like high blood pressure can put the heart at risk of heart failure.
Levosimed 12.5mg Injection may not be recommended for patients with severe liver disease. It should be used with caution in people with mild or moderate liver impairment. While no dose adjustment is typically needed, it's essential to monitor your liver function closely to ensure safe treatment. Inform the doctor if you have liver impairment or liver disease.
Levosimed 12.5mg Injection may cause a decrease in blood pressure. To ensure your safety, your blood pressure will be closely monitored after receiving the medicine. This will help the doctor detect any changes and take necessary actions.
Inform the doctor if you have kidney disease before receiving Levosimed 12.5mg Injection. Dose adjustment may be needed in people with mild to moderate kidney problems and it may not be recommended for patients with severe kidney problems.
Before and during treatment with Levosimed 12.5mg Injection, your doctor may advise monitoring of heart, kidneys, and liver function, ECG, blood pressure, and blood tests. The doctor may also check your urine output to ensure safety.
Levosimed 12.5mg Injection may increase heart rate. The doctor will take appropriate action if they notice a fast heart rate during treatment with Levosimed 12.5mg Injection.
Headaches are a common side effect of Levosimed 12.5mg Injection. To manage headaches, make sure to get plenty of rest, eat a balanced diet, and avoid alcohol. If your headache becomes severe, be sure to consult your doctor for further guidance and support.
The common side effects of Levosimed 12.5mg Injection include headache, low blood pressure, and nausea (stomach discomfort). Most of these side effects of Levosimed 12.5mg Injection do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

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