Kombiglyze XR 5mg/500mg Tablet is used in the treatment of type 2 diabetes in adults. Kombiglyze XR 5mg/500mg Tablet is prescribed for the condition of type 2 diabetes when diet and exercise alone cannot control blood sugar levels. People with type 2 diabetes either do not produce enough insulin, or the insulin produced is unable to perform its function in the body (insulin resistance). Middle-aged or older individuals are most likely to suffer from type 2 diabetes, so it is also known as adult-onset diabetes.

Kombiglyze XR 5mg/500mg Tablet contains two medications: Saxagliptin and Metformin. Saxagliptin works by blocking the action of DPP-4/dipeptidyl peptidase-4  (an enzyme which destroys the hormone ‘Incretin’). The enzyme ‘Incretins’ helps produce more insulin only when required and reduces blood sugar produced by the liver when not needed. On the other hand, Metformin, a 'biguanide', lowers the liver's glucose production, delays glucose absorption from the intestines, and increases the body's response to insulin. Together, they prevent the blood glucose levels from rising to very high levels, thus keeping your diabetes under control.

You are suggested to take Kombiglyze XR 5mg/500mg Tablet for as long as your doctor has prescribed it. The most common side effects of Kombiglyze XR 5mg/500mg Tablet are hypoglycemia (low blood glucose levels), upper respiratory tract infection, nasopharyngitis (nose and throat infection with common cold), and headache. Most of these side effects do not require medical attention and gradually resolve over time. If the side effects persist or worsen, consult a doctor.

Kombiglyze XR 5mg/500mg Tablet should not be stopped even if you feel better. If you stop taking Kombiglyze XR 5mg/500mg Tablet abruptly, it may increase your sugar levels, which could further increase the risk of eyesight loss (retinopathy), kidney (nephropathy), and nerve damage (neuropathy). Kombiglyze XR 5mg/500mg Tablet should not be taken if you have severe kidney or liver disease. Please inform your doctor if you have any heart disease, are planning to get pregnant or are breastfeeding. Safety and efficacy of Kombiglyze XR 5mg/500mg Tablet in children under 18 years have not been established, so it should not be given to them. Patients taking digoxin (a heart medicine) with Kombiglyze XR 5mg/500mg Tablet should be closely monitored as severe drug interaction has been observed.

Kombiglyze XR 5mg/500mg Tablet contains two medications: Saxagliptin and Metformin. Kombiglyze XR 5mg/500mg Tablet helps keep your blood sugar levels under check. Kombiglyze XR 5mg/500mg Tablet shows optimum effects when taken along with healthy lifestyle changes like weight loss, regular exercise, healthy diet, etc. Kombiglyze XR 5mg/500mg Tablet plays a vital role in controlling blood sugar levels and prevents serious complications of diabetes like eyesight loss (retinopathy), kidney (nephropathy), nerve damage (neuropathy), diabetic foot ulcer, and delayed wound healing.

• Dizziness
• Sweating
• Palpitations
• Dry mouth and skin
• Hypoglycaemia (low blood glucose level)

A prolonged intake of Kombiglyze XR 5mg/500mg Tablet may cause acute pancreatitis (swollen pancreas) and critical kidney problem. Increased risk of hypoglycemia (low blood sugar level) can occur when Kombiglyze XR 5mg/500mg Tablet is added to other anti-diabetic agents or insulin therapy. In this case, your doctor may adjust the dose of Kombiglyze XR 5mg/500mg Tablet. Severe allergic reactions might occur in some patients taking Kombiglyze XR 5mg/500mg Tablet, like anaphylaxis, angioedema (swelling under the skin), and exfoliative skin conditions, including Stevens-Johnson syndrome. 

Drug-Drug Interaction: Kombiglyze XR 5mg/500mg Tablet interacts with an anti-depressant (bupropion), drugs used to treat glaucoma, antibiotics (cephalexin, ciprofloxacin), anti-acidity drugs (cimetidine), heart condition drugs (digoxin), anti-HIV drugs (dolutegravir), ethanol, saliva reducing drugs (glycopyrrolate), iodinated X-ray contrast agents, anti-epileptic drugs (topiramate, lamotrigine), heart-related chest medicine (ranolazine). Other drug interactions can contribute to an increased low blood sugar, including sex hormones (androgens), anti-oxidant (alpha-lipoic acid), painkillers (aspirin), anti-TB drugs (prothionamide), growth hormones (pegvisomant), and other antidiabetic medicines.

Drug-Food Interaction: Intake of excessive alcoholic beverages may increase the chance of a life-threatening condition known as Lactic Acidosis. So, avoid intake of alcoholic beverages with Kombiglyze XR 5mg/500mg Tablet.

Drug-Disease Interaction: Kombiglyze XR 5mg/500mg Tablet should be used with caution in patients with a history of pancreatitis/pancreatic disease and renal dysfunction.

• DOLUTEGRAVIR
• RANOLAZINE
• TOPIRAMATE
• ASPIRIN
• DIGOXIN
• CIMETIDINE
• CIPROFLOXACIN
• BUPROPION

• Invest at least 150 min of your week in moderate-intensity physical activity or one hour and 15 minutes of high-intensity exercise every week.

• Replace refined carbohydrate-containing foods with whole grain foods and increase intake of fruits and vegetables and other fibre-enriched foods.

• Reduce saturated fat (or hidden fats) intake in food like chips, crisps, pastries, biscuits, and samosas. Choose omega-3 fatty acid-containing oils for daily cooking. For frying, you can use palm oil, mustard oil, groundnut oil, rice bran oil, and safflower oil.

• Avoid taking too much stress as it may elevate your blood sugar level. You can adopt stress management techniques like mindfulness to control stress-related blood sugar changes or meditation or yoga.

• Opt for low-fat dairy products (low-fat yoghurt, fat-free milk, cheese, etc.).

Continue to take Kombiglyze XR 5mg/500mg Tablet unless you are advised otherwise by your doctor, as a treatment for diabetes is usually lifelong.

Type 2 diabetes: It is a condition where the body is unable to make sufficient insulin, or the insulin that it makes doesn't work properly or is utilized by our body. This can cause high blood sugar levels (hyperglycemia). Symptoms of type 2 diabetes include increased thirst, frequent urination,  increased hunger, fatigue, and blurred vision. In some cases, there may be weight gain, while in rare cases, weight loss may be observed. The complication of type 2 diabetes includes neuropathy (nerve problems), nephropathy (kidney problems), retinopathy (damaged retina of eyes or blindness), loss of limbs, sexual dysfunction, and increased chance of heart attack or stroke.