Knogle 200 Nasal Spray 60Md 6Ml belongs to groups of medications called hypocalcemic agents, used to treat high blood calcium levels (hypercalcemia) and Postmenopausal Osteoporosis. Besides this, it can also help treat complications of Paget's disease. Hypercalcemia is a condition in which the calcium level in your blood is above normal. Postmenopausal osteoporosis is a medical condition that causes thinning and weakening of the bones during/after a menopausal period. Paget’s disease is a chronic disease of bone that disrupts the replacement of old bone tissue with new bone tissue, resulting in the new bone that is abnormally shaped, weak and brittle.

Knogle 200 Nasal Spray 60Md 6Ml contains Calcitonin. It reduces the activity of osteoclasts, which are the cells responsible for bone breakdown. When bone is broken down, the calcium in the bone is released into the bloodstream. As a result, calcitonin's suppression of osteoclasts limits the quantity of calcium released into the blood. Furthermore, it can reduce calcium resorption in the kidneys, resulting in decreased blood calcium levels.

Knogle 200 Nasal Spray 60Md 6Ml will be administered by a qualified healthcare professional. Kindly do not self-administer. In some cases, Knogle 200 Nasal Spray 60Md 6Ml can cause side effects, including injection site reactions, nausea with or without vomiting and flushing of the face or hands. Most of these side effects of Knogle 200 Nasal Spray 60Md 6Ml do not require medical attention and gradually resolve over time. However, if these side effects persist longer, please consult your doctor.

Before taking the Knogle 200 Nasal Spray 60Md 6Ml, let your doctor know about all your medical conditions, sensitivities, and all medications you are using. And also, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Knogle 200 Nasal Spray 60Md 6Ml should not be given to children as safety and efficacy have not been established.

Knogle 200 Nasal Spray 60Md 6Ml contains calcitonin, which belongs to groups of medications called hypocalcemic agents and is used to treat high blood calcium levels (hypercalcemia) and Postmenopausal Osteoporosis. On the other hand, it can also help people with Paget's disease of bone. Knogle 200 Nasal Spray 60Md 6Ml reduces the activity of osteoclasts, which are the cells responsible for bone breakdown. When bone is broken down, the calcium in the bone is released into the bloodstream. As a result, calcitonin's suppression of osteoclasts limits the quantity of calcium released into the blood. Furthermore, it can reduce calcium resorption in the kidneys, decreasing blood calcium levels.

• Injection site reactions
• Nausea with or without vomiting
• Flushing of the face or hands

Before taking the Knogle 200 Nasal Spray 60Md 6Ml, let your doctor know about all your medical conditions, sensitivities, and all medications you are using. And also, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Knogle 200 Nasal Spray 60Md 6Ml should not be given to children as safety and efficacy have not been established. In rare situations, Knogle 200 Nasal Spray 60Md 6Ml may cause major hypersensitivity reactions in individuals receiving Miacalcin injection, including bronchospasm, inflammation of the tongue or throat and anaphylactic shock. If you encounter any of these symptoms, contact your doctor right once.

Drug-Drug interactions: Knogle 200 Nasal Spray 60Md 6Ml may interact with certain medicines used to treat mood disorders (e.g. lithium), medicines used to treat secondary hyperparathyroidism (e.g. etelcalcetide) and antiviral medications (e.g. foscarnet).

Drug-Food interactions: No interaction found.

Drug-Disease interactions: Knogle 200 Nasal Spray 60Md 6Ml interacts with disease conditions, including hypocalcaemia (low calcium level) and mineral metabolism disorder.

• LITHIUM
• ETELCALCETIDE
• FOSCARNET

• A person should consume calcium and vitamin D in their diet as it helps make stronger bones and avoid everyday osteoporosis dangers.

• A post-menopausal woman should limit salt intake as it can pose a high risk of losing more bone minerals than other women of the same age.

• Do regular exercise like weight-bearing exercises which are important for maintaining bone health.

• Calcium is important for making bones strong. Vitamin D is equally important, which helps to ensure the absorption and retention of calcium in bones, so take food high in calcium and vitamins.

• Certain diagnostic tests, like blood tests, measure the calcitonin level in your blood, and bone density scans are used to check bone mineral density (BMD).

• Clinical monitoring of serum electrolyte concentrations is recommended.

Postmenopausal Osteoporosis: Postmenopausal Osteoporosis is a medical condition that causes thinning and weakening of the bones during/after a menopausal period. The chance of developing Osteoporosis (weak bone) is related to estrogen deficiency. During the menopausal period (45 years of age), the drop in estrogen leads to more bone resorption (osteoclasts; bone breakdown) than formation (osteoblast; new bone formation), resulting in Osteoporosis. In starting days, Osteoporosis does not show any symptoms. However, if proper treatment is not provided, it can lead to broken bones. Initially, the bones don't hurt, and breaks in the spine's bones may go unseen until they cause height loss. In Osteoporosis, bones can break at any time, even during daily activities like lifting or even from minor activities. 

Paget's disease: Paget's disease is a chronic disease of bone that disrupts the replacement of old bone tissue with new bone tissue, resulting in the new bone that is abnormally shaped, weak and brittle. It most commonly occurs in the pelvis, skull, spine, and legs. Symptoms include bone pain, joint pain (especially in the back, hips, and knees), headache, enlargement and bowing of the thighs (femurs) and lower legs (tibias), and enlargement of the skull in the area of the forehead.

Hypercalcemia: Hypercalcemia is when the calcium level in the blood is higher than normal. Too much calcium in the blood can weaken the bones, create kidney stones, and interfere with working the heart and brain. It is usually a result of overactive parathyroid glands. Symptoms include increased thirst and urination, stomach pain, nausea, bone pain, muscle weakness, confusion and fatigue.