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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 9, 2024 | 12:40 PM IST
Histonate Plus Expectorant is used to treat cough. It contains Salbutamol and Guaifenesin, which relaxes muscles and widens the airways. Thereby, it makes breathing easier. It works by increasing the volume of fluid in the airways, reduce the stickiness of mucus, and helps to remove it from the airways. Some people may experience side effects such as nausea, vomiting, drowsiness, stomach upset, headache, dizziness, skin rash, tremor, restlessness, tension and rapid heartbeat. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions. Drink plenty of fluids while taking this medicine to loosen mucus.
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Prescription drug

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Manufacturer/Marketer

Ornate Labs Pvt Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Histonate Plus Expectorant

Histonate Plus Expectorant belongs to the class of medications called expectorants primarily used to treat cough. Coughing (dry or productive) is a body’s way of clearing irritants (like allergens, mucus, or smoke) from airways and preventing infection. There are two types of coughs, namely: dry cough and chesty cough. A dry cough is tickly and doesn't produce any vicious or thick mucus, while a chesty cough (wet cough) means mucous or sputum is produced to help clear your airways. 

Histonate Plus Expectorant is a combination of two drugs, namely: Salbutamol (bronchodilator) and Guaifenesin (expectorant). Salbutamol belongs to the class of bronchodilators that relaxes muscles and widens the airways. Thereby, it makes breathing easier. Guaifenesin belongs to the class of expectorants that works by increasing the volume of fluid in the airways, reduce the stickiness of mucus, and helps to remove it from the airways.

Take Histonate Plus Expectorant as prescribed. Your doctor will recommend how often you take Histonate Plus Expectorant based on your medical condition. Some people may experience nausea, vomiting, drowsiness, stomach upset, headache, dizziness, skin rash, tremor, restlessness, tension and rapid heartbeat. Most of these side effects of Histonate Plus Expectorant do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Histonate Plus Expectorant or any other medicines, please tell your doctor. Histonate Plus Expectorant is not recommended for children below 2 years of age, as the safety and effectiveness were not established. If you are pregnant or breastfeeding, it is advised to inform your doctor before using Histonate Plus Expectorant . If you have diabetes, regular monitoring of blood sugar levels is recommended while taking Histonate Plus Expectorant . If you are about to undergo any surgery that requires anesthesia, please inform your doctor that you are taking Histonate Plus Expectorant . If you experience constipation, leg cramps, numbness or tingling, increased urination or thirst, muscle weakness, or irregular heartbeats, contact your doctor as it may be due to low potassium levels in the blood. Drink plenty of fluids while taking Histonate Plus Expectorant to loosen mucus. If you have diabetes, asthma, overactive thyroid, enlarged prostate, phenylketonuria (a birth defect that causes accumulation of amino acid, phenylalanine in the body), kidney, liver, or heart problems, inform your doctor before taking Histonate Plus Expectorant .

Uses of Histonate Plus Expectorant

Treatment of Cough

Medicinal Benefits

Histonate Plus Expectorant is a combination of two drugs, namely: Salbutamol (bronchodilator) and Guaifenesin (expectorant). Together Histonate Plus Expectorant helps to relieve respiratory obstruction and improve pulmonary ventilation, especially in the conditions of respiratory disorders like asthma, bronchitis, and emphysema. Histonate Plus Expectorant minimizes the bronchospasm (sudden narrowing of airways) and excessive secretion of viscous mucus (which blocks airways). 

Directions for Use

Shake the bottle well before use. Check the label for directions before use. Take Histonate Plus Expectorant with or without food as prescribed by your doctor with the help of a measuring cup that is provided with the pack.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Histonate Plus Expectorant

  • Nausea
  • Vomiting
  • Drowsiness
  • Stomach upset
  • Headache
  • Dizziness
  • Skin rash
  • Tremor
  • Restlessness
  • Tension
  • Rapid heartbeat

Drug Warnings

If you are allergic to Histonate Plus Expectorant or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to inform your doctor before using Histonate Plus Expectorant . Histonate Plus Expectorant is not recommended for children below 2 years of age, as the safety and effectiveness were not established. If you have diabetes, regular monitoring of blood sugar levels is recommended while taking Histonate Plus Expectorant . If you are about to undergo any surgery that requires anesthesia, please inform your doctor that you are taking Histonate Plus Expectorant . If you experience constipation, leg cramps, numbness or tingling, increased urination or thirst, muscle weakness, or irregular heartbeats, contact your doctor as it may be due to low potassium levels in the blood. Drink plenty of fluids while taking Histonate Plus Expectorant to loosen mucus. If you have diabetes, asthma, overactive thyroid, enlarged prostate, phenylketonuria (a birth defect that causes accumulation of amino acid, phenylalanine in the body), kidney, liver, or heart problems, inform your doctor before taking Histonate Plus Expectorant .

Drug Interactions

Drug-Drug Interaction: Histonate Plus Expectorant may have interaction with medicines used to lower high blood pressure (propranolol, reserpine, methyldopa, guanethidine), tricyclic antidepressants (amitriptyline, imipramine, amoxapine).

Drug-Food Interaction: Histonate Plus Expectorant may interact with caffeine. Therefore, avoid or limit the intake of caffeinated beverages, foods, or dietary supplements with Histonate Plus Expectorant as it may increase the risk of adverse effects.

Drug-Disease Interaction: If you have diabetes, asthma, overactive thyroid, enlarged prostate, phenylketonuria (a birth defect that causes accumulation of amino acid, phenylalanine in the body), kidney, liver, or heart problems, inform your doctor before taking Histonate Plus Expectorant .

Drug-Drug Interactions Checker List

  • PROPRANOLOL
  • RESERPINE
  • METHYLDOPA
  • GUANETHIDINE
  • AMITRIPTYLINE
  • IMIPRAMINE
  • AMOXAPINE

Habit Forming

No

Diet & Lifestyle Advise

  • Avoid dairy products such as milk as it may increase mucus production. Also, avoid processed or refined foods to have relief from cough. Instead replace baked foods, fried foods, white bread, white pasta, French fries, sugary desserts, and chips with green leafy vegetables.
  • Drink plenty of fluids to avoid dry throat while you have a cough and loosen mucus.
  • Avoid citrus fruits as they may worsen the cough. Eat fruits rich in water content such as pears, watermelon, peaches, and pineapples.

Special Advise

  • Regularly monitor blood sugar levels while taking Histonate Plus Expectorant , especially if you have diabetes as Histonate Plus Expectorant may increase blood sugar levels.
  • Monitor blood potassium levels while taking Histonate Plus Expectorant , especially in asthma patients, as it may cause low potassium levels in the blood.

Disease/Condition Glossary

Cough: Coughing is a body’s way of clearing irritants (like allergens, mucus, or smoke) from airways and preventing infection. Coughs may be dry or productive. A productive cough (wet cough) brings up sputum (phlegm, mucus, and other matter) from the lungs. Cough is commonly caused as a response to allergy or viral infection but coughing up mucus is possibly an indication of infection in the respiratory tract. If you are coughing thick, solid white mucus, it indicates you may have a bacterial infection in the airways. If the mucus is clear or light-colored, it indicates you may have allergies or a minor infection in the respiratory tract, and yellow or green mucus indicates a respiratory infection. Cough production is common in asthma, COPD, and other respiratory disorders like bronchitis (airway inflammation and infection). 

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Alcohol

Caution

Interaction of alcohol with Histonate Plus Expectorant is unknown. Please consult a doctor before consuming alcohol with Histonate Plus Expectorant .

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Pregnancy

Caution

The safety of Histonate Plus Expectorant in pregnant women is unknown. Therefore, it is given to pregnant women only if the doctor thinks benefits outweigh risks.

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Breast Feeding

Caution

Salbutamol present in Histonate Plus Expectorant is excreted in human milk. So, it is advisable to avoid breastfeeding while using Histonate Plus Expectorant . Histonate Plus Expectorant should be given to breastfeeding mothers only if the doctor thinks benefits are greater than risks.

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Driving

Caution

Histonate Plus Expectorant may cause dizziness or drowsiness in some people. Therefore, drive only if you are alert after taking Histonate Plus Expectorant .

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Liver

Caution

Take Histonate Plus Expectorant with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Histonate Plus Expectorant with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Caution

Histonate Plus Expectorant is not recommended for children below 2 years of age. However, please consult a doctor before using Histonate Plus Expectorant in children.

Country of origin

India

Manufacturer/Marketer address

NO 43,44,METHA NAGAR EXTN PALLAVARAM ROAD,KUNDRATHUR CHENNAI TN 600069 IN
Other Info - HIS0050

Author Details

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FAQs

Histonate Plus Expectorant is used to treat cough.
Histonate Plus Expectorant contains Salbutamol and Guaifenesin. Salbutamol is a bronchodilator that relaxes bronchi (airways) muscles and widens it thereby, makes breathing easier, especially asthma and COPD patients. Guaifenesin is an expectorant that works by increasing the volume of fluid in the airways, reduce the stickiness of mucus and helps to remove it from airways.
Histonate Plus Expectorant should be used with caution in hyperthyroid (overactive thyroid) patients as it may worsen the condition. Inform your doctor if have hyperthyroidism before taking Histonate Plus Expectorant so that the dose may be adjusted appropriately. However, regular monitoring of thyroid hormone levels is recommended while taking Histonate Plus Expectorant .
No, you are not recommended to take propranolol with Histonate Plus Expectorant as it may reduce the effectiveness of both the medicines. Also, propranolol may cause narrowing of airways sometimes, which may trigger severe asthmatic attacks or worsen breathing problems. However, you are recommended to consult a doctor before using other medicines with Histonate Plus Expectorant .
Histonate Plus Expectorant is not recommended for diabetic patients as it may increase blood sugar levels. However, regular monitoring of blood sugar levels is recommended while taking Histonate Plus Expectorant .
Yes, Histonate Plus Expectorant may cause drowsiness or dizziness. It is not necessary for everyone taking Histonate Plus Expectorant to experience this side effect. However, avoid driving or doing any hazardous tasks if you feel drowsy or dizzy after taking Histonate Plus Expectorant .
You are recommended to take Histonate Plus Expectorant for as long as your doctor has prescribed it. However, if the symptoms persist or worsen with rash, fever or persistent headache after one week of using Histonate Plus Expectorant , please consult your doctor.
No, you are not recommended to stop taking Histonate Plus Expectorant without consulting your doctor as it may worsen cough or cause recurring symptoms. Therefore, take Histonate Plus Expectorant for as long as your doctor has prescribed it, and if you experience any difficulty while taking Histonate Plus Expectorant , please consult your doctor.

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