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Written By , M Pharmacy
Reviewed By , M Pharmacy
Last Updated Jan 1, 2025 | 2:48 PM IST
Grenate Plus Tablet is used to treat migraine. It contains Propranolol and Flunarizine which improves blood flow and dilates blood vessels in the brain, thereby preventing headaches caused due to migraine. It effectively treats and reduces the severity and frequency of migraine headaches. Also, it is also used to treat vertigo (spinning sensation). It may cause common side effects such as dry weight gain, slow heart rate, tiredness, depression, drowsiness, abnormal dreams, and cold extremities (hands and feet). Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Prescription drug

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Manufacturer/Marketer :

Gentech Healthcare Pvt Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Grenate Plus Tablet

Grenate Plus Tablet is used to treat migraine. Migraine is a medical condition that involves severe throbbing pain or a pulsing sensation on one side of the head. Severe and recurrent headaches are one of the characteristic symptoms of migraine. Its symptoms include nausea, vomiting, difficulty speaking, numbness or tingling, and sensitivity to light and sound.

Grenate Plus Tablet consists of 'Propranolol' (beta-blocker) and 'Flunarizine' (calcium channel blocker). Propranolol has anxiolytic (anxiety-reducing), anti-arrhythmic (treats abnormal heart rhythms), and antihypertensive (reduces blood pressure) properties. Propranolol works by reducing cerebral (brain) blood flow by directly acting on the brain's blood vessels. It also inhibits the cortical spreading of depression and electrical activity in the brain that causes pain and inflammation. It effectively treats and reduces the severity and frequency of migraine headaches. Flunarizine belongs to the class of calcium channel blockers. It improves blood flow and dilates blood vessels in the brain, thereby preventing headaches caused by migraine. It is also used to treat vertigo (spinning sensation).

Your doctor will decide the dose and duration based on the severity of your pain. Common side effects of Grenate Plus Tablet include dry weight gain, slow heart rate, tiredness, depression, drowsiness, abnormal dreams, and cold extremities (hands and feet). These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Let your doctor know if you use any prescription and non-prescription medications you are taking, including other vitamins, before starting Grenate Plus Tablet . Grenate Plus Tablet may cause weight gain in some cases, so avoid eating junk and eat a healthy, balanced diet, including home-cooked food. Consult your doctor before taking Grenate Plus Tablet if you are pregnant, planning for pregnancy or breastfeeding. Avoid consuming alcohol along with Grenate Plus Tablet as it could lead to increased drowsiness.

Uses of Grenate Plus Tablet

Treatment of Migraine.

Medicinal Benefits

Grenate Plus Tablet is used to treat migraine. It consists of 'Propranolol' and 'Flunarizine'. Propranolol is a beta-blocker and has anxiolytic (anxiety-reducing), anti-arrhythmic, and antihypertensive properties. It works by lowering cerebral (brain) blood flow and inhibits cortical spreading depression, as well as electrical activity in the brain that causes pain and inflammation. It reduces the severity and frequency of migraine headaches. Flunarizine is a channel blocker that improves blood flow and dilates blood vessels in the brain, thereby preventing headaches caused by migraine. 

Side Effects of Grenate Plus Tablet

  • Weight gain
  • Slow heart rate
  • Tiredness
  • Depression
  • Drowsiness
  • Abnormal dreams
  • Cold extremities (hands and feet)

Directions for Use

Swallow Grenate Plus Tablet as a whole with a glass of water; do not chew, crush or break it.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Inform your doctor if you have any history of liver or kidney diseases, breathing problems (asthma, bronchitis, emphysema), diabetes, heart failure, heart rhythm problems (sinus bradycardia, Wolff-Parkinson-White syndrome, atrioventricular block), overactive thyroid, blood circulation problems (Raynaud's disease), adrenal gland tumour (pheochromocytoma), depression, metabolic acidosis (excess acid in the blood), and myasthenia gravis (muscle weakness) before starting Grenate Plus Tablet . Please consult your doctor if you are pregnant and planning to conceive if the doctor advised you Grenate Plus Tablet . Avoid consuming alcohol along with Grenate Plus Tablet as it could lead to increased dizziness and drowsiness.

Therapeutic Class

ANTIMIGRAINE AGENTS

Diet & Lifestyle Advise

  • Avoid chocolates, junk food, cheese, processed food, alcohol, and smoking. Instead, eat a healthy diet and do regular exercise to avoid weight gain caused due to Grenate Plus Tablet .
  • Avoid loud music, extreme temperatures, bright lights, and noisy places as it can increase headache.
  • You can try increasing your mindfulness by doing yoga, meditation, mindfulness-based cognitive therapy, and stress reduction techniques.
  • Drink enough water to stay hydrated and limit or avoid alcohol and caffeine to relieve headaches.
  • Include a diet rich in whole grains, vegetables, and fruits. This is a healthier option than eating a lot of simple carbohydrates found in processed foods.
  • You can include antioxidants in your daily diet like ashwagandha, omega-3 fatty acids, green tea, and lemon balm.
  • Try to spend time with your friends and family. Having a strong social network may help you lower your risk of anxiety.

Habit Forming

No

How Grenate Plus Tablet Works

Grenate Plus Tablet consists of 'Propranolol' (beta-blocker) and 'Flunarizine' (calcium channel blocker). Propranolol has anxiolytic (anxiety-reducing), anti-arrhythmic (treats abnormal heart rhythms), and antihypertensive (reduces blood pressure) properties. Propranolol works by reducing cerebral (brain) blood flow by directly acting on the brain's blood vessels. It also inhibits the cortical spreading of depression and electrical activity in the brain that causes pain and inflammation. It effectively treats and reduces the severity and frequency of migraine headaches. Flunarizine belongs to the class of calcium channel blockers. It improves blood flow and dilates blood vessels in the brain, thereby preventing headaches caused by migraine.

What if I have taken an overdose of Grenate Plus Tablet

Do not take more than the prescribed dose of Grenate Plus Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Grenate Plus Tablet . Alcohol intake, along with Grenate Plus Tablet , may cause increased dizziness and drowsiness.

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Pregnancy

Caution

Please consult your doctor if you are pregnant or planning to conceive before using Grenate Plus Tablet .

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Breast Feeding

Caution

Please consult your doctor before taking Grenate Plus Tablet if you are a lactating mother.

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Driving

Caution

Grenate Plus Tablet may make you feel drowsy. Do not drive or operate machinery if you experience drowsiness.

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Liver

Caution

Therapy with propranolol should be administered cautiously in patients with liver disease. Please consult your doctor if you have a history of liver impairment/liver disease.

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Kidney

Caution

Plasma clearance of Propranolol in Grenate Plus Tablet is reduced in patients with renal failure. Please consult your doctor if you have a history of kidney impairment/kidney disease.

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Children

Safe if prescribed

Grenate Plus Tablet is safe to use for children below 12 years of age when prescribed by the doctor.

Country of origin

India

Manufacturer/Marketer address

Crown Heights ,709,7th Floor, Near Rithala Metro Station, Opp. JIMS College., Sector-10, Rohini-110085. New Delhi
Other Info - GRE0153

Author Details

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FAQs

Grenate Plus Tablet belongs to the class of anti-migraine drugs used to treat migraine.
Grenate Plus Tablet is a combination of two drugs: Propranolol and Flunarizine. Grenate Plus Tablet treats migraine by reducing the blood flow to the brain, and inhibits cortical spreading depression, electrical activity in the brain that causes pain and inflammation.
Grenate Plus Tablet may sometimes cause weight gain during its prolonged use. It is always advised to maintain a well-balanced, healthy diet and exercise regularly.
Grenate Plus Tablet does not work for a sudden migraine attack. It is helpful in only preventing new episodes of migraine headaches. Please let your doctor know if you have sudden attacks to be prescribed other suitable medications.
Grenate Plus Tablet is contraindicated in asthma, slow heart rate, abnormal heart rhythms, heart conditions like AV (Atrioventricular) block or sick sinus syndrome, depression, and Parkinson's disease. Please consult your doctor before starting Grenate Plus Tablet if you have a medical history.
Your doctor will prescribe Grenate Plus Tablet to prevent any new episodes of migraine. Please do not stop taking this medicine unless advised by your doctor since it may lead to recurrent episodes of migraine. Grenate Plus Tablet also contains Propranolol, and its sudden withdrawal may cause sweating, shaking, irregular heartbeat, and worsening of underlying angina or heart attack. Hence, do not stop using Grenate Plus Tablet unless advised by your doctor.

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