Glirega M 1mg/500mg Tablet SR belongs to a class of medicines called anti-diabetic drugs used in the treatment of type 2 diabetes, especially in patients whose blood sugar levels are not controlled by diet and exercise alone. Type 2 diabetes is a chronic (long-lasting) condition that affects the way our body processes glucose. People with type 2 diabetes either do not produce enough insulin, or the insulin produced is unable to perform its function in the body (insulin resistance).

Glirega M 1mg/500mg Tablet SR is a combination of two antidiabetic drugs, namely: Glimepiride and Metformin. Glimepiride works by stimulating beta cells in the pancreas that produce insulin. Thus, insulin helps to remove sugar from the blood. Metformin works by reducing the sugar production by cells in the liver and delays sugar absorption from the intestines. Also, it increases the sensitivity of muscle cells to insulin, which enables these cells to remove sugar more effectively from the blood.

Take Glirega M 1mg/500mg Tablet SR as prescribed by your doctor. You are advised to take Glirega M 1mg/500mg Tablet SR for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience stomach pain, nausea, diarrhoea, vomiting, headache or metallic taste. Most of these side effects of Glirega M 1mg/500mg Tablet SR do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Glirega M 1mg/500mg Tablet SR or any other medicines, please tell your doctor. Glirega M 1mg/500mg Tablet SR is not recommended for children. Avoid breastfeeding while taking Glirega M 1mg/500mg Tablet SR as it may be excreted in human milk. If you are pregnant or planning for pregnancy, please inform your doctor before taking Glirega M 1mg/500mg Tablet SR as it may harm the unborn baby. Avoid alcohol consumption with Glirega M 1mg/500mg Tablet SR as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body). Drive only if you are alert after taking Glirega M 1mg/500mg Tablet SR. Take short, frequent meals and avoid prolonged fasting while taking Glirega M 1mg/500mg Tablet SR.

Glirega M 1mg/500mg Tablet SR contains Glimepiride and Metformin used to treat type 2 diabetes. Glimepiride stimulates cells in the pancreas that produce insulin, which helps remove sugar from the blood. Metformin reduces sugar production by cells in the liver and delays sugar absorption from the intestines. Also, it increases the sensitivity of muscle cells to insulin, which enables these cells to remove sugar more effectively from the blood.

• Stomach pain
• Nausea
• Diarrhoea
• Vomiting
• Headache
• Metallic taste

If you are allergic to Glirega M 1mg/500mg Tablet SR or any other medicines, please tell your doctor. Glirega M 1mg/500mg Tablet SR is not recommended for children. Avoid breastfeeding while taking Glirega M 1mg/500mg Tablet SR as it may be excreted in human milk. If you are pregnant or planning for pregnancy, please inform your doctor before taking Glirega M 1mg/500mg Tablet SR as it may harm the unborn baby. Avoid alcohol consumption with Glirega M 1mg/500mg Tablet SR as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body). Drive only if you are alert after taking Glirega M 1mg/500mg Tablet SR. Take short, frequent meals and avoid prolonged fasting while taking Glirega M 1mg/500mg Tablet SR. Beware of symptoms of hypoglycemia (low blood sugar), which include sweating, dizziness, palpitations, shivering, intense thirst, dry mouth, dry skin, frequent urination, etc. Whenever you experience any of these symptoms, immediately consume 5-6 candies or 3 glucose biscuits, or 3 teaspoons of honey/sugar, and also consult your doctor. Make sure to carry these with you at all times, especially during long travels.

Drug-Drug Interaction: Glirega M 1mg/500mg Tablet SR may have interaction with antibiotics (rifampicin, trimethoprim), calcium channel blockers (verapamil), antacids (cimetidine), HIV/AIDS drugs (dolutegravir), heart-related medicine (ranolazine), anticancer drugs (vandetanib, crizotinib, olaparib), antifungals (fluconazole, miconazole), water pill (acetazolamide), antidiabetic drug (insulin), anticonvulsants (phenytoin).

Drug-Food Interaction: Glirega M 1mg/500mg Tablet SR may interact with alcohol. Therefore, avoid the consumption of alcohol with Glirega M 1mg/500mg Tablet SR as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

Drug-Disease Interaction: If you have severe infections, uncontrolled diabetes, lactic acidosis or ketoacidosis (accumulation of ketone bodies in the blood), dehydration, or liver or kidney problems, inform your doctor before taking Glirega M 1mg/500mg Tablet SR.

• RIFAMPICIN
• TRIMETHOPRIM
• VERAPAMIL
• CIMETIDINE
• DOLUTEGRAVIR
• RANOLAZINE
• VANDETANIB
• CRIZOTINIB
• OLAPARIB
• FLUCONAZOLE
• MICONAZOLE
• ACETAZOLAMIDE
• INSULIN
• PHENYTOIN

• Do regular exercise such as cycling, walking, jogging, dancing, or swimming for a minimum of 30 minutes per day. Invest at least 150 minutes of your week in exercise.

• Maintain healthy body weight as obesity is also related to the onset of diabetes.

• Maintain a low-fat and low-sugar diet. Replace carbohydrates-containing foods with whole grains, fruits, and vegetables as carbohydrates turn to sugars leading to high blood sugar.

• Avoid consumption of alcohol and quit smoking.

Regular blood tests are recommended while taking Glirega M 1mg/500mg Tablet SR to monitor blood sugar levels.

Type 2 diabetes: It is a chronic (long-lasting) condition that keeps the body away from properly utilizing insulin. Hence, people affected with type 2 diabetes either do not produce enough insulin or there is resistance to the action of insulin. Middle-aged or older are most likely to suffer from type 2 diabetes, so it is also known as adult-onset diabetes. Symptoms of type 2 diabetes include frequent urination at night, increased thirst, slow wound healing, increased hunger, fatigue, and blurred vision. In some cases, there may be weight gain, while in rare cases, weight loss may be observed. The complication of type 2 diabetes also includes nerve problems, kidney problems, damaged retina of eyes or blindness, loss of limbs, sexual dysfunction, and increased chance of heart attack or stroke.