Durart-R 450 Tablet belongs to a group of medicines called antiretroviral agents indicated for the treatment of HIV infection. It may decrease the chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer.

Durart-R 450 Tablet contains Ritonavir and Darunavir. They work by decreasing the amount of HIV in the blood and increasing the number of immune cells that help fight infections in the body. Thereby, Durart-R 450 Tablet helps treat HIV infection.

In some cases, Durart-R 450 Tablet may cause side effects such as headache, nausea, vomiting, diarrhoea, and abdominal pain. Most of these side effects may not require medical attention and resolve gradually over time. However, you are advised to talk to the doctor if the side effects persist or worsen.

Consult the doctor if you are pregnant or planning for pregnancy. Breastfeeding is not recommended due to the potential for HIV transmission. Keep the doctor informed about your health condition and medicines you are taking to prevent any side effects/interactions.

Durart-R 450 Tablet is used to treat HIV infection. It contains Ritonavir and Darunavir, both of which belong to the protease inhibitors class of medicines. Durart-R 450 Tablet helps treat HIV infection by reducing the amount of HIV in the blood. This helps improve the immune system and lowers the risk of developing illnesses related to HIV, such as acquired immunodeficiency syndrome (AIDS), serious infections, or cancer.

• Nausea
• Vomiting
• Diarrhoea
• Abdominal pain
• Headache

Do not take Durart-R 450 Tablet if you are allergic to any of its components. Inform the doctor if you have/had hepatitis B or C infection, liver, kidney or heart problems, diabetes, haemophilia (bleeding disorder) or if you are allergic to sulpha drugs. Consult the doctor if you are pregnant or planning for pregnancy. Women with HIV should not breastfeed as the virus may pass to the baby through breast milk. Let the doctor know if you take other medicines, including supplements or herbal products.

Drug-Drug Interactions: Inform the doctor if you are taking lipid-lowering agents (rosuvastatin, atorvastatin), anti-coagulant (apixaban), anti-HIV (etravirine, emtricitabine, tenofovir), analgesic (oxycodone), anti-anxiety (alprazolam), hormone (testosterone), calcium channel blocker (diltiazem), or anti-emetic (ondansetron).

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform the doctor if you have liver problems, haemophilia, diabetes, hyperlipidaemia, or heart block.

• ROSUVASTATIN
• ATORVASTATIN
• APIXABAN
• ETRAVIRINE
• TENOFOVIR
• OXYCODONE
• ALPRAZOLAM
• TESTOSTERONE
• DILTIAZEM
• ONDANSETRON

• Practise safe sex by using latex or polyurethane condom; it helps in reducing contact with semen and vaginal fluids.
• Never share personal items with body fluids or blood on them, such as razor blades or toothbrushes.
• Do not share or re-use needles, other injection or drug equipment.
• Eat a healthy and balanced diet. Include fruits and vegetables, and opt for lean protein and whole grains.
• Avoid eating raw meat and eggs. Consume properly boiled and cooked meat, poultry or seafood.
• Try to reduce emotional and physical stress by spending time with family or by doing whatever makes you happy.

HIV infection: HIV (Human Immunodeficiency Virus) is a virus that attacks the immune system and destroys the white blood cells that help fight infection, making the individual susceptible to other infections or illnesses. People with HIV experience flu-like symptoms such as fever, chills, rash, night sweats, muscle aches, tiredness, and sore throat. These symptoms usually last for days to several weeks. HIV spreads through body fluids such as semen, vaginal fluid, and blood. If left untreated, this condition can lead to AIDS (Acquired Immunodeficiency Syndrome). It is a life-long condition, and there is no definite cure for it. However, it can be controlled by treating it with antiretroviral drugs.