Dotrasulide 40mg/100mg Tablet

Dotrasulide 40mg/100mg Tablet belongs to the group of medicines called muscle relaxants indicated for the relief of painful skeletal muscle spasms. Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Muscle spasms are involuntary contractions of muscles that can be painful. Musculoskeletal pain affects the bones, muscles, ligaments, tendons, and nerves.

Dotrasulide 40mg/100mg Tablet is a combination of two drugs: Nimesulide (NSAID) and Drotaverine (Muscle relaxant). Nimesulide works by inhibiting the synthesis of prostaglandins which are responsible for pain and inflammation. Drotaverine acts on the brain and spinal cord centers where it inhibits the multisynaptic reflex involved in muscle spasms, thereby providing relief from skeletal muscle spasms or stiffness. Together, Dotrasulide 40mg/100mg Tablet helps in relieving musculoskeletal pain.

Take Dotrasulide 40mg/100mg Tablet as directed by your doctor. You are advised to take Dotrasulide 40mg/100mg Tablet for as long as your doctor has prescribed it for you depending on your medical condition. You may experience certain common side effects such as nausea, vomiting, diarrhoea, dryness in the mouth, and dizziness in some cases. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take Dotrasulide 40mg/100mg Tablet if you are pregnant or breastfeeding unless prescribed by the doctor. Dotrasulide 40mg/100mg Tablet is not recommended for children as safety and effectiveness have not been established. Avoid consuming alcohol along with Dotrasulide 40mg/100mg Tablet as it could increase the risk of stomach bleeding. Dotrasulide 40mg/100mg Tablet may cause sleepiness and dizziness, so drive only if you are alert. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Dotrasulide 40mg/100mg Tablet is a combination of two drugs, namely: Nimesulide and Drotaverine. Dotrasulide 40mg/100mg Tablet is used to relieve pain and stiffness caused by muscle strains and sprains. Nimesulide is an NSAID that inhibits the synthesis of prostaglandins responsible for pain and inflammation. Drotaverine is a muscle relaxant that acts on the brain and spinal cord centers where it inhibits the multisynaptic reflex involved in muscle spasms, thereby providing relief from skeletal muscle spasms or stiffness. Together, Dotrasulide 40mg/100mg Tablet helps in relieving pain due to muscle spasms.

• Nausea
• Vomiting
• Diarrhoea
• Dryness in mouth
• Feeling thirsty
• Dizziness
• Increased liver enzymes

Do not take Dotrasulide 40mg/100mg Tablet if you are allergic to any of its contents, if you have bled into the brain, impaired liver function, blood clotting problems, stomach or intestinal ulcers or bleeding, severe heart failure, or non-dialyzed severe kidney failure. Inform your doctor before taking Dotrasulide 40mg/100mg Tablet if you have heart problems, or kidney or liver impairment. Do not take Dotrasulide 40mg/100mg Tablet if you are pregnant or breastfeeding unless prescribed by the doctor. Dotrasulide 40mg/100mg Tablet is not recommended for children as safety has not been established. Avoid consuming alcohol along with Dotrasulide 40mg/100mg Tablet as it could increase the risk of stomach bleeding. Dotrasulide 40mg/100mg Tablet may cause sleepiness and dizziness, so drive only if you are alert. Stop taking Dotrasulide 40mg/100mg Tablet and consult your doctor immediately if you have stomach pain or any signs of bleeding in the intestine or stomach such as blood in stools. Do not take any other NSAIDs for pain relief along with Dotrasulide 40mg/100mg Tablet unless prescribed. Concomitant use of levodopa and Dotrasulide 40mg/100mg Tablet should be avoided. Inform your doctor if you have a history of wheezing, chest tightness, breathlessness, sudden skin or mucosal swelling, and skin rashes after taking NSAID medication.

Drug-Drug Interactions: Dotrasulide 40mg/100mg Tablet may have interaction with a blood thinner (warfarin), corticosteroids (medicines used in the treatment of inflammatory conditions), lithium which is used to treat depression, methotrexate (a medicine used for the treatment of rheumatoid arthritis), cyclosporine (a medicine used after transplantation) and levodopa (a medicine used for the central nervous system). 

Drug-Food Interactions: Avoid alcohol consumption while taking Dotrasulide 40mg/100mg Tablet as it might cause an increased risk of stomach bleeding.

Drug-Disease Interactions: Dotrasulide 40mg/100mg Tablet may have interactions with severe kidney, liver, or heart failure.

• WARFARIN
• LITHIUM
• METHOTREXATE
• CYCLOSPORINE
• LEVODOPA

• Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
• Performing yoga may also help in improving joint flexibility and pain management.
• Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
• Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.
• Follow heat or cold therapy, apply a cold or hot compress on the joints for 15-20minutes regularly.
• De-stress yourself by meditating, reading books, taking a warm bubble bath, or listen to soothing music.
• Acupuncture, massage, and physical therapy may also be helpful.
• Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
• Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes, and green tea.

If you experience bloody or tarry stools, change in urine colour stop using Dotrasulide 40mg/100mg Tablet, and consult a doctor.

Musculoskeletal pain: Musculoskeletal pain affects the bones, muscles, ligaments, tendons, and nerves. It can be acute or chronic and can be localized or widespread. The pain can be mild or severe enough to interfere with your daily routine. Musculoskeletal pain could occur due to arthritis, osteoporosis, fractures, dislocations, problems with the bone structure, or injury to the bones, joints, tendons, muscles, and ligaments. Symptoms of musculoskeletal pain include stiffness, swelling, redness, weakness, muscle spasms or twitching, trouble moving the affected area, soreness, and cracking or popping sounds at the joints.

Muscle spasm: The sudden involuntary contractions of the muscle can be painful and uncomfortable. When the nerve impulses that control the muscle movements are damaged or interrupted, it could lead to muscle spasms. Symptoms include muscle tightness, joint stiffness, unusual posture, difficulty moving, pain in affected muscles, and joints. Fatigue (weakness), stress, extreme heat or cold, infection, and tight clothing can trigger muscle spasms. Muscle relaxants and exercise can treat muscle spasms. Muscle relaxants sedate the muscle and help in inhibiting painful contractions. Exercise helps in muscle stretching so that they are less likely to spasm, tear, and sprain.