Depzeal-Plus Tablet is used to treat moderate to severe depression associated with moderate to severe anxiety. Depression is a mood disorder characterised by sadness, unhappiness, anger, hopelessness or loss. Anxiety is a mental health disorder characterised by feelings of anxiety, worry or fear that are strong enough to interfere with one’s daily activities. Anxiety and depression can occur at the same time.

Depzeal-Plus Tablet is a combination of two drugs: Amitriptyline (tricyclic anti-depressant) and Chlordiazepoxide (benzodiazepine anxiolytic). Amitriptyline works by affecting certain chemical messengers in the brain that communicate between brain cells, thereby regulating mood and treating depression. Chlordiazepoxide works by increasing the action of a chemical messenger called GABA. This helps suppress the excessive and abnormal activity of the nerve cells in the brain. 

You are advised to take Depzeal-Plus Tablet only for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects such as dizziness, drowsiness, dry mouth, constipation, blurred vision and bloating. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Consult your doctor immediately if you have suicidal thoughts, such as killing or harming yourself. Do not take Depzeal-Plus Tablet if you are pregnant, as it may cause birth defects. Consult your doctor before taking Depzeal-Plus Tablet if you are breastfeeding. Avoid driving or operating machinery as Depzeal-Plus Tablet causes sleepiness and dizziness and might impair thinking and motor skills. Avoid consuming alcohol along with Depzeal-Plus Tablet as it could lead to increased drowsiness and dizziness. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Depzeal-Plus Tablet is a combination of two drugs: Amitriptyline and Chlordiazepoxide. Depzeal-Plus Tablet is used to treat moderate to severe depression and anxiety. Amitriptyline is a tricyclic anti-depressant that affects certain chemical messengers (serotonin and/or norepinephrine) in the brain, which communicate between brain cells, thereby regulating mood and treating depression. Chlordiazepoxide is a benzodiazepine anxiolytic that works by increasing the action of a chemical messenger called GABA. This helps suppress the excessive and abnormal activity of the nerve cells in the brain. Depzeal-Plus Tablet has a calming effect on various functions of the brain. Thereby, Depzeal-Plus Tablet helps in treating anxiety and depression.

• Drowsiness
• Dry mouth
• Nasal congestion
• Constipation
• Blurred vision
• Dizziness
• Bloating

Do not take Depzeal-Plus Tablet if you are allergic to any of its contents, if you recently had a heart attack or heart problems, are taking monoamine oxidase inhibitors (MAOI). Do not take opioids with Depzeal-Plus Tablet as it may result in increased sedation, depression, coma and death. Depzeal-Plus Tablet should not be taken for longer durations as it may cause physical dependence. Inform your doctor before taking Depzeal-Plus Tablet if you have bipolar disorder, eye problems, urination problems, seizures, thyroid problems, kidney or liver problems or if you are due to have any surgery. Consult your doctor immediately if you have suicidal thoughts, such as killing or harming yourself. Talk to your doctor before taking Depzeal-Plus Tablet if you have a history of drug abuse, addiction or alcohol abuse as Depzeal-Plus Tablet may cause dependence. Do not take Depzeal-Plus Tablet if you are pregnant, as it may cause birth defects. Consult your doctor before taking Depzeal-Plus Tablet if you are breastfeeding. Avoid driving or operating machinery as Depzeal-Plus Tablet causes sleepiness, dizziness and might impair thinking and motor skills. Avoid consuming alcohol along with Depzeal-Plus Tablet as it could lead to increased drowsiness and dizziness. Depzeal-Plus Tablet should not be given to children as safety and effectiveness have not been established.

Drug-Drug Interactions: Depzeal-Plus Tablet may interact with an anti-depressant (duloxetine, venlafaxine), anti-convulsant (gabapentin, pregabalin, topiramate), anti-thyroid (levothyroxine), anti-anxiety (alprazolam), corticosteroid (fluticasone), beta-agonist (salmeterol), anti-anxiety (lorazepam), opioid analgesic (morphine) and diuretic (furosemide).

Drug-Food Interactions: Avoid consuming alcohol along with Depzeal-Plus Tablet as it may cause increased sedative effects.

Drug-Disease Interactions: Inform your doctor if you have closed-angle glaucoma, respiratory depression, seizures, low blood pressure, pheochromocytoma (tumour of the adrenal gland), porphyria, bone marrow suppression, obesity, diabetes, schizophrenia, glaucoma, bipolar disorder, thyroid disorder, urinary retention, tardive dyskinesia (involuntary facial movements), heart, liver or kidney problems.

• DULOXETINE
• VENLAFAXINE
• GABAPENTIN
• PREGABALIN
• TOPIRAMATE
• LEVOTHYROXINE SODIUM
• ALPRAZOLAM
• LORAZEPAM
• FLUTICASONE+SALMETEROL
• FUROSEMIDE
• MORPHINE

• Maintain a healthy diet and exercise regularly as it helps in improving overall health and boosts self-esteem.

• Regularly attend therapy sessions.

• Perform meditation and yoga. This helps in relieving stress and provides relaxation.

• Follow a regular sleep pattern to improve the amount and quality of sleep you get.

• Include foods rich in omega-fatty acids such as fish, nuts, fresh fruits, vegetables and olive oils.

• Neurotransmitters are made up of amino acids. Amino acid-rich foods such as meat, dairy products and certain fruits and vegetables help in the proper maintenance of neurotransmitters.

• Complex carbohydrates help in stimulating serotonin (a feel-good neurotransmitter). These include whole grains, legumes, spinach, broccoli, oranges and pears.

• Exercising helps in the production of the body’s natural anti-depressants. It also helps in relieving stress, improving mood, boosting self-esteem and providing restful sleep.

• Avoid smoking and alcohol consumption.

• Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

• Do not stop taking Depzeal-Plus Tablet on your own; sudden stopping of Depzeal-Plus Tablet may cause withdrawal symptoms. Consult your doctor if you have any concerns, the doctor may reduce the dose gradually.

• Consult your doctor immediately if you develop any suicidal thoughts.

• Women of childbearing age should use effective contraception while taking Depzeal-Plus Tablet .

Depression: It is a mood disorder characterised by the feeling of sadness, unhappiness, anger, hopelessness or loss that interferes with a person’s daily activities. Depression can also influence some chronic health conditions and relationships. The exact cause of depression is unknown, but it may be associated with mental problems, trauma, family history, drug use and medical conditions. Symptoms of depression include loss of interest, hopelessness, difficulty concentrating, appetite changes, irritability, feeling of emptiness, sadness and restlessness.

Anxiety: It is a mental health disorder characterised by feelings of anxiety, worry or fear that are strong enough to interfere with one’s daily activities. Anxiety is the body’s natural response to stress, in which the feeling of fear may be intense and debilitating. It is the most common form of emotional disorder and can affect anyone, at any age. Anxiety may cause a panic attacks, obsessive-compulsive disorder and post-traumatic stress disorder. The exact cause of anxiety is unknown, but it might be due to genetic or environmental factors. Symptoms of anxiety include rapid breathing, increased heart rate, restlessness, trouble concentrating and difficulty falling asleep.