Cox-SP Tablet belongs to the class of drugs known as pain killer/ 'non-steroidal anti-inflammatory drug' (NSAID). Cox-SP Tablet is used to provide pain relief in various conditions including post-traumatic pain, low back pain, cervical pain, spondylitis (inflammation in spinal bones), osteoarthritis (joint pain and stiffness), rheumatoid arthritis (joint pain and damage throughout the body), migraine, etc. Pain can be temporary (acute) or prolonged period (chronic) in nature. Acute pain is for a short time caused by damage to the tissues of the muscle, bone or organs. Chronic pain lasts for long time caused due to nerve damage, osteoarthritis, dental pain, etc., due to damage to the tooth nerve, infection, decay, extraction or injury. 

Cox-SP Tablet contains two medicines namely etoricoxib and serratiopeptidase. Cox-SP Tablet contains ‘etoricoxib’ which works by blocking the release of a chemical messenger called prostaglandin, produced by COX-2, which is responsible for pain, swelling and inflammation. Serratiopeptidase is a proteolytic enzyme which helps in the breakdown of insoluble protein (fibrin) a by-product of blood clot into smaller units. It also causes thinning of the fluids in the body as a result of injury, thereby making fluid drainage smoother in the swollen tissue. Together Cox-SP Tablet is effective for relieving pain.

Take Cox-SP Tablet as prescribed by your doctor. You are advised to take Cox-SP Tablet for as long as your doctor has prescribed it for you depending on your medical conditions. You may experience stomach pain, diarrhea, flatulence, indigestion, feet swelling, swelling of hands and flu-like symptoms. Most of these side effects of Cox-SP Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Do not take Cox-SP Tablet if you are allergic to Cox-SP Tablet , other pain killers or any other ingredients present in it. Cox-SP Tablet should not be taken in the conditions like ulcers or bleeding in your stomach, severe liver and/or kidney impairment, colitis (inflammation of the large intestine), uncontrolled blood pressure, heart problems such as chest pain, heart attack or heart failure and stroke. Cox-SP Tablet is not recommended for children below 16 years of age. Before taking Cox-SP Tablet inform your doctor if you are more than 65 years of age. Inform your doctor immediately if you are pregnant, planning to become pregnant or breastfeeding.

Cox-SP Tablet is used to provide pain relief in various conditions including post-traumatic pain, low back pain, cervical pain, spondylitis (inflammation in spinal bones), osteoarthritis (lifelong joint pain and stiffness), rheumatoid arthritis (joint pain and damage throughout the body), migraine, etc. Etoricoxib in Cox-SP Tablet plays a vital role in reducing pain and inflammation by blocking the release of chemical messengers that cause pain and inflammation. Serratiopeptidase present in Cox-SP Tablet is a proteolytic enzyme that helps in the breakdown of insoluble protein (fibrin) a by-product of blood clots into smaller units. It also causes thinning of the fluids in the body as a result of injury, thereby making fluid drainage smoother in the swollen tissue.

• Stomach pain
• Dry mouth
• Diarrhea
• Flatulence
• Indigestion
• High blood pressure
• Dizziness
• Feet swelling
• Swelling of hands 
• Flu-like symptoms

Before taking Cox-SP Tablet , inform your doctor if you have a history of stomach bleeding or ulcer, liver or kidney diseases, dehydration because of prolonged vomiting or diarrhea and swelling due to fluid retention. Inform your doctor if you have high blood pressure that is not treated or controlled as Cox-SP Tablet may increase blood pressure in some cases. Do not take Cox-SP Tablet if you are treated for infection as Cox-SP Tablet can mask fever (a sign of infection). Use of Cox-SP Tablet is contraindicated in kidney failure patients or who are undergoing dialysis. Inform your doctor if you are dehydrated (because of vomiting or diarrhea), have edema (swelling due to fluid retention). Patients who have had recently undergone heart bypass surgery should take Cox-SP Tablet with caution and only under medical supervision. Do not take Cox-SP Tablet if you smoke, have diabetes (high blood sugar) or high cholesterol as Cox-SP Tablet increases the risk of heart attack or stroke. Avoid lying down for at least half an hour after using Cox-SP Tablet . People who have had any heart attack and stroke in the past should not take Cox-SP Tablet . Do not drive or operate heavy machinery as intake of Cox-SP Tablet may cause dizziness.

Drug-Drug Interactions: Cox-SP Tablet may interact with anticoagulant (warfarin, heparin, aspirin, clopidogrel), immunosuppressant (methotrexate), antihypertensives (enalapril, ramipril, losartan, valsartan, and minoxidil), medicines used for mood swings (lithium), antimalarial (primaquine), a medicine used to prevent pregnancy (ethinyl estradiol).

Drug-Food Interactions: Drinking alcohol should be avoided while taking Cox-SP Tablet as it can cause unpleasant effects.

Drug-Disease Interactions: Cox-SP Tablet should be used with caution in patients with stomach ulcers or bleeding, severe kidney disease, liver diseases, colitis (inflammation of the large intestine), uncontrolled blood pressure, heart failure, stroke and other heart problems.

• WARFARIN
• ASPIRIN
• METHOTREXATE
• ENALAPRIL
• RAMIPRIL
• LOSARTAN
• VALSARTAN
• MINOXIDIL
• LITHIUM
• PRIMAQUINE
• ETHINYLESTRADIOL
• HEPARIN
• CLOPIDOGREL

• Include more glucosamine, chondroitin sulfate, Vitamin D, calcium-enriched supplements. Besides this, turmeric and fish oils can help in reducing inflammation in the tissue.
• Please do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do stretching, low impact aerobic exercise like walking on a treadmill, bike riding and swimming. You can also strengthen your muscle strength by lifting light weights.
• In the chronic condition of arthritis or joint pain, including fish like salmon, trout, tuna and sardines. These fishes are enriched with omega-3 fatty acids that minimum level of chemical called cytokines, which ramp up inflammation.
• Your sitting posture is important, especially when have pain and inflammation condition. Try to sit little as possible and only for a short time (10-15 min). Use back support like a rolled-up towel at the back of your curve to minimize pain. Keep your knees and hips at a right angle. Besides this, you can use a footrest if required.
• Do not take spicy, fried and processed foods.
• Drink plenty of water to stay hydrated. 
• Quit smoking and limit caffeine and alcohol intake.

• Your doctor may monitor liver and kidney function if Cox-SP Tablet is prescribed for the long term. 
• Inform your doctor before taking Cox-SP Tablet , if you had a history of a heart attack or bypass surgery.

Musculoskeletal pain: Different types of musculoskeletal pain are caused due to soft tissues (muscle, tendon, and ligaments) injury. Extreme tissue pain and inflammation caused due to sprains, strains, trauma or post-surgery may require a prolonged amount of time to heal. Different types of musculoskeletal pain are caused due to soft tissues (muscle, tendon, and ligaments) injury. Extreme tissue pain and inflammation are caused due to sprains, strains or trauma or post-surgery. These types of injuries may require a prolonged amount of time to heal. 

Osteoarthritis: Osteoarthritis is the common type of arthritis in which the cartilage that cushions the ends of the bones erodes due to wear and tear over time. Common symptoms are joint pain and stiffness.

Rheumatoid arthritis (RA): Rheumatoid arthritis (RA) is an autoimmune disease in which the immune cells attack the joints and cause bone erosion leading to severe pain and swelling. It may lead to joint deformity if left untreated.

Ankylosing spondylitis: Ankylosing spondylitis is a type of arthritis in which inflammation is seen in the spine and large joints. It leads to pain and stiffness in the back and affected joints.

Gout: Gout is an inflammatory condition in which uric acid deposits and crystallizes in the joints. It is characterized by acute, severe and recurring attacks of pain, especially at night, redness and swelling in the affected joints.