Coolnerve-P 50 Tablet belongs to the class of medications ‘anticonvulsants’ used in the treatment of neuropathic pain. Neuropathic pain is a chronic (long-term) progressive nerve disease that causes nerve pain due to nerve damage or the nervous system's malfunctioning. It is mostly seen in patients who had suffered a trauma or nerve injury, diabetes, vitamin deficiencies, cancer, multiple sclerosis (disease of the brain and spinal cord), shingles (a viral infection), and HIV.

Coolnerve-P 50 Tablet is a combination of two medicines: Pregabalin and Methylcobalamin. Pregabalin acts by decreasing the pain signals sent by a damaged nerve in the body. On the other hand, Methylcobalamin helps rejuvenate and protect damaged nerve cells by producing a substance called myelin (outer protective layer of nerve cell - neuron).

You should take this medicine as prescribed by your doctor. The common side-effects of Coolnerve-P 50 Tablet are dizziness, drowsiness, headache, anorexia (loss of appetite), nausea or vomiting, diarrhea, headache, hot sensation (burning pain), vision problems, and diaphoresis (sweating). Inform your doctor if any of these side effects persist.

Do not take Coolnerve-P 50 Tablet if you are allergic to ‘Pregabalin’ and ‘Methylcobalamin’ or any contents before taking Coolnerve-P 50 Tablet if you have a history of heart diseases, liver or kidney disease, alcoholism, or drug abuse.  It should not be used in children and adolescents below 18 years. Inform your doctor if you are pregnant and breastfeeding. Do not drive or operate heavy machinery as Coolnerve-P 50 Tablet may cause dizziness or drowsiness. Coolnerve-P 50 Tablet contains lactose, so inform your doctor if you have any intolerance to sugars. Do not discontinue treatment without telling your doctor. 

Coolnerve-P 50 Tablet is a combination of two drugs: Pregabalin and Methylcobalamin. Pregabalin is an anticonvulsant that affects the brain's chemicals that send pain signals across the nervous system. It works by binding to the specific site on voltage-gated calcium channels (responsible for excitatory response), thereby decreasing brain activity. This effect helps in relieving nerve pain and lowers the risk of seizures. On the other hand, Methylcobalamin is a form of vitamin B12 that helps rejuvenate and protect damaged nerve cells by producing a substance called myelin (outer protective layer of nerve cells). Together, Coolnerve-P 50 Tablet helps in providing relief from neuropathic pain and improved nerve signal conduction.  

• Dizziness
• Drowsiness
• Headache
• Anorexia (loss of appetite)
• Nausea or vomiting
• Diarrhea
• Headache
• Sore throat
• Vision problems
• Hot sensation (burning pain)
• Diaphoresis (sweating)
• Weight gain

Coolnerve-P 50 Tablet may increase the risk of heart failure in patients with heart diseases. It may cause dizziness and somnolence (sleepiness). So, it might increase the risk of accidental injury in elderly patients. Coolnerve-P 50 Tablet may also cause temporary vision problems. However, if this condition is persistent, consult your doctor immediately. Patients with diabetes who gain weight with Coolnerve-P 50 Tablet may need a change in diabetic medicines. If you notice decreased urination while taking Coolnerve-P 50 Tablet , inform your doctor as Coolnerve-P 50 Tablet may cause kidney failure in some cases. It may increase suicidal tendencies, though it is rare. You may experience convulsions after discontinuing Coolnerve-P 50 Tablet . In such cases, inform your doctor immediately.  

Drug-Drug Interaction: Coolnerve-P 50 Tablet may interact with a pain killer (oxycodone), opioids, antianxiety drugs (lorazepam), antacid (omeprazole), antibiotic (neomycin), and anti-gout medication (colchicine). 

Drug-Food Interaction: Avoid alcohol consumption while using Coolnerve-P 50 Tablet . 

Drug-Disease Interaction: Coolnerve-P 50 Tablet should be used with caution in patients with liver diseases, kidney diseases, heart problems, alcoholism, drug abuse, and suicidal tendencies. 

• OXYCODONE
• LORAZEPAM
• OMEPRAZOLE
• COLCHICINE
• NEOMYCIN

• Include food rich in vitamin B and D in your diet.

• Include cayenne pepper in your diet as it can help in lowering neuropathic pain.

• Exercising regularly helps in improving overall health and combating pain.

• Rest well, get plenty of sleep.

• Try taking a warm bath as it can be soothing.

• Avoid smoking and alcohol consumption.

• Meditation and yoga can help lower stress, decrease pain sensitivity, and improves coping skills.

• Acupuncture can be helpful by stimulating pressure points.

• Using essential oils for massages can help increase circulation.

• Coolnerve-P 50 Tablet may increase suicidal thoughts. Extreme caution is advised with people suffering from suicidal tendencies or psychological problems.

• Coolnerve-P 50 Tablet is known to cause dizziness and sleepiness, so it is advised to refrain from driving or doing any work that requires attention or concentration.

Neuropathic pain: Neuropathic pain is caused due to damage to sensory nerves. It is caused by chronic progressive nerve disease, infection, or injury. The pain could be intermittent or continuous, which is felt as a prickling, stabbing, tingling, or burning sensation. A feeling of numbness and loss of sense is also a common symptom of neuropathic pain. Usually, the body sends the pain signals when there is an injury, but with neuropathic pain, the pain is not triggered by an injury, the body unpromptedly sends the pain signals. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, difficulty resting or sleeping, and evoked pain (pain caused by events usually not painful).