Clopinol-AT Tablet is a combination drug composed of a blood-thinning agent and cholesterol-lowering agent primarily used to prevent heart attack and stroke in the future. It lowers the raised level of cholesterol and fats (triglycerides) in our bodies. A heart attack occurs when your coronary arteries (blood vessels supplying blood and oxygen to the heart) becomes blocked due to the build-up of fats (plaque), including cholesterol. These plaques narrow the arteries, leading to atherosclerosis and coronary artery disease, mainly for most heart attacks.

Clopinol-AT Tablet is composed of two medicines, namely: Atorvastatin and Clopidogrel. Atorvastatin is a lipid-lowering medication which blocks the enzyme required to make cholesterol in the body. As a result, it lowers the bad cholesterol (low-density lipoproteins or LDL) and triglycerides (TG) and increases the levels of good cholesterol (high-density lipoproteins or HDL). Clopidogrel is a blood thinner (anticoagulant) that collectively prevents a clot in the blood vessels. Together Clopinol-AT Tablet reduces the increased levels of bad cholesterol (low-density lipoprotein and triglycerides) and prevents blood clots, thereby reducing the risk of heart attack, stroke and heart-related chest pain (angina).

You can take Clopinol-AT Tablet with food or without food. It should be swallowed whole with a glass of water. Do not chew, bite, or break it. Your doctor will advise you on how often you take this medicine based on your medical condition. You may sometimes experience headaches, ankle swelling (oedema), slow heart rate, and nausea. Clopinol-AT Tablet is known to cause dizziness, so driving should be avoided. Most of these side effects of Clopinol-AT Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Try not to stop taking a Clopinol-AT Tablet of your own. Suddenly stopping using Clopinol-AT Tablet may worsen your condition and increase your risk of a future heart attack. Let your doctor know if you are sensitive to atorvastatin or clopidogrel or have any active liver disease (liver enzyme abnormalities), active bleeding issues (like peptic ulcer, brain haemorrhage), or muscle problem (myopathy, rhabdomyolysis). The patient should inform the doctor they are taking Clopinol-AT Tablet before any surgery or any new medicine is taken. Atorvastatin, present in Clopinol-AT Tablet is a pregnancy category X drug, so it should not be given to pregnant women. It may cause harm to the foetus if administered to pregnant or breastfeeding women.

Atorvastatin is a lipid-lowering medication that blocks the enzyme required to make cholesterol in the body. As a result, it lowers the bad cholesterol (low-density lipoproteins or LDL) and triglycerides (TG) and increases the levels of good cholesterol (high-density lipoproteins or HDL). Clopidogrel is a blood thinner (anticoagulant) that collectively prevents clot formation in the blood vessels. Together Clopinol-AT Tablet reduces the increased levels of bad cholesterol (low-density lipoprotein and triglycerides) and prevents blood clots, thereby reducing the risk of heart attack, stroke and heart-related chest pain (angina).

• Bleeding (stomach, gastrointestinal, nose bleeding)

• Rash

• Diarrhoea

• Stomach ulcer

• Muscle disease (like myopathy, rhabdomyolysis)

• Abdominal pain

Tell your doctor if you are sensitive to Atorvastatin or clopidogrel, have any active liver disease, active bleeding issues (like peptic ulcer, brain haemorrhage), are pregnant or planning to become pregnant or breastfeeding. The patient should inform the doctor that they are taking Clopinol-AT Tablet before any surgery is scheduled or any new medicine is taken. Atorvastatin present in Clopinol-AT Tablet is a pregnancy category X drug, so it is contraindicated in pregnant women. As it may cause harm to the foetus if administered to pregnant women. The risk of muscle disease might increase if Clopinol-AT Tablet is taken with an antibiotic (clarithromycin), anti-HIV drugs (ritonavir, lopinavir, darunavir, atazanavir, indinavir) and antifungal (itraconazole). Coadministration with anticoagulants like warfarin may cause gastric bleeding and other bleeding problems. So, if you are using any blood-thinning agents, let your doctor know about this. Clopinol-AT Tablet contains Atorvastatin which can cause muscle problems like myopathy and rhabdomyolysis. Patients with active liver disease should use the Clopinol-AT Tablet with caution. The safety and effectiveness of Clopinol-AT Tablet have not been established, so its use should be avoided in paediatric patients or children younger than ten years of age. Discontinuation of Clopinol-AT Tablet may lead to cardiovascular events like heart attack, stroke and angina (heart-related chest pain). Hence, you should consult a doctor before stopping the dose of Clopinol-AT Tablet .

Drug-Drug Interactions: Clopinol-AT Tablet interacts with antibiotics (e.g. clarithromycin), anti-HIV drugs (e.g. ritonavir, lopinavir, darunavir, atazanavir, indinavir), antifungal (e.g. itraconazole), blood thinners (e.g. warfarin, coumadin, heparin), anti-arthritis drug (e.g. colchicine), heart-related medicine (e.g. digoxin) and immune system affecting drug (e.g. cyclosporine).

Drug-Food Interactions: Alcoholic beverages and grapefruit or its juice intake should be avoided with Clopinol-AT Tablet . It may interact with Clopinol-AT Tablet to produce unpleasant side effects like muscle problems and bleeding disorder.

Drug-Disease Interactions: Caution should be exercised while using Clopinol-AT Tablet in patients with active liver disease, active bleeding issues (like peptic ulcer, brain haemorrhage), muscle problems or musculoskeletal problems (myopathy, rhabdomyolysis), asthma, and purpura (blood leakage under the skin).

• CLARITHROMYCIN
• RITONAVIR
• LOPINAVIR
• DARUNAVIR
• ATAZANAVIR
• INDINAVIR
• ITRACONAZOLE
• WARFARIN
• COUMADIN
• HEPARIN
• COLCHICINE
• DIGOXIN
• CYCLOSPORINE

• Low cholesterol diet along with a regular exercise regime is found to complement treatment with Clopinol-AT Tablet effectively.

• Stick to a freshly prepared home-cooked meal and avoid processed, packed foods that contain hidden sugar and extra calories.

• Try to replace most of your saturated fats with unsaturated fats to reduce total cholesterol and LDL cholesterol (bad cholesterol) quickly.

• Foods like avocados, olive oil, fatty fish and nuts contain many heart-healthy unsaturated fats, so eating them regularly is beneficial.

• Include a diet enriched in fats like fish oils, polyunsaturated oils, and omega-3 fatty acids, which are good for heart health.

• Quit smoking and avoid excessive intake of alcohol.

• If you have a high cholesterol level, try to have a lipid profile test (LFT) every 6 months.

Atherosclerosis: Atherosclerosis occurs when fats, cholesterol, and other substances known as plaque deposit on your artery walls that restrict blood flow. This plaque formation triggers blood clots, narrows the arteries' size, and hardens them. This, in turn, can lead to various heart complications like atherosclerosis, heart attack, heart-related chest pain (angina), and stroke. However, it can also affect the body's arteries apart from the heart.