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Reviewed By , MPharma., PhD
Last Updated Jan 1, 2025 | 9:32 AM IST

Celrixafor Injection is used in the treatment of Non-Hodgkin’s Disease (a blood cancer that affects your lymph system) and multiple myeloma (a type of cancer that affects the plasma cells of the bone marrow). Celrixafor Injection contains Plerixafor, which belongs to the hemopoietic stem cell mobilizer class or drugs. It works by releasing stem cells from the bone marrow, making them available to collect from your bloodstream.

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Prescription drug

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Composition :

PLERIXAFOR-24MG

Manufacturer/Marketer :

Celon Laboratories Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Celrixafor Injection

Celrixafor Injection belongs to the class of hemopoietic stem cell mobilizer. It is used in the treatment of Non-Hodgkin’s Disease (a blood cancer that affects your lymph system) and multiple myeloma (a type of cancer that affects the plasma cells of the bone marrow) in combination with granulocyte-colony stimulating factor (G-CSF).

Celrixafor Injection contains Plerixafor, which belongs to the hemopoietic stem cell mobilizer class or drugs. It works by binding to the chemokine receptor CXCR4 and inhibits the binding of its cognate ligand CXCL12.

Celrixafor Injection may cause certain side effects, such as nausea, vomiting, headache, dizziness, diarrhoea, flatulence, fatigue, and pain at the site of injection. These side effects do not require medical attention and gradually resolve over time. A trained healthcare professional will administer it. Do not self-administer.

Avoid taking it and inform your doctor if you are allergic to Celrixafor Injection or its components. Before administration, inform your doctor if you have liver/kidney disease, cardiac disorders, blood disorders or respiratory conditions. This medicine is known to cause fetal harm in pregnant women. Hence, inform your doctor if you are pregnant or are planning to become pregnant. Breastfeeding should be discontinued during the treatment.

Uses of Celrixafor Injection

Treatment of Multiple Myeloma, Non-Hodgkin's Disease

Medicinal Benefits

Celrixafor Injection contains Plerixafor, which belongs to the hemopoietic stem cell mobilizer class or drugs. It works by binding to the chemokine receptor CXCR4 and inhibiting its cognate ligand CXCL12 binding. This mobilizes hematopoietic stem cells to the peripheral blood for collection and subsequent autologous transplantation in cancer patients.

Side Effects of Celrixafor Injection

  • Nausea
  • Dizziness
  • Stomach upset
  • Headache
  • Vomiting
  • Insomnia
  • Arthralgia
  • Diarrhoea
  • Pain at the site of injection

Directions for Use

Celrixafor Injection will be administered by a trained healthcare professional. Hence, do not self-administer. 

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Celrixafor Injection should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before administration, inform your doctor if you have liver/kidney disease, cardiac disorders, blood disorders, anaemia, or respiratory conditions. Celrixafor Injection may cause the potential for tumor cell mobilization in leukemia patients, haematological effects, and splenic rupture in some patients. Hence, careful monitoring should be done during the entire treatment. This medicine is known to cause fetal harm in pregnant women. Hence, inform your doctor if you are pregnant or are planning to become pregnant. Breastfeeding should be discontinued in nursing mothers during the treatment. Celrixafor Injection should be avoided in children as safety is not established.

Therapeutic Class

CHEMOTHERAPY

Drug-Drug Interactions

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No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Diet & Lifestyle Advise

  • After your treatment begins, several dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals to take during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans, and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast and fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

How Celrixafor Injection Works

Celrixafor Injection contains Plerixafor, which belongs to the hemopoietic stem cell mobilizer class or drugs. It works by binding to the chemokine receptor CXCR4 and inhibits the binding of its cognate ligand CXCL12.

What if I have taken an overdose of Celrixafor Injection

As Celrixafor Injection is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away. Overdose of Celrixafor Injection may cause nausea, vomiting, stomach pain, diarrhea, gas, dizziness or lightheadedness, and fainting.
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Alcohol

Unsafe

It is unknown whether Celrixafor Injection interacts with alcohol or not. Please consult your doctor.

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Pregnancy

Unsafe

Celrixafor Injection is not recommended for use in pregnancy as it may harm your fetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Celrixafor Injection. Effective birth control is necessary during treatment and for one week after your last dose.

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Breast Feeding

Unsafe

Celrixafor Injection is not recommended if you are breastfeeding. You should not breastfeed while taking this medication and for one week after your last dose.

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Driving

Caution

Celrixafor Injection is generally administered to hospitalized patients. Driving is not advised after taking this medicine.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Celrixafor Injection. A dose adjustment may be made, or a suitable alternative may be advised based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Celrixafor Injection. A dose adjustment may be made, or a suitable alternative may be advised based on your condition.

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Children

Unsafe

Celrixafor Injection is not recommended for use in children as the safety and efficacy are not established.

Country of origin

INDIA

Manufacturer/Marketer address

Plot No 264, Patrika Nagar Madhapur, Hitech City Hyderabad, Telangana India - 500081
Other Info - CEL0216

Author Details

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FAQs

Celrixafor Injection is used to treat Multiple Myeloma, Non-Hodgkin’s Disease.
Celrixafor Injection contains Plerixafor, which works by binding to the chemokine receptor CXCR4 and inhibits the binding of its cognate ligand CXCL12.
Celrixafor Injection may cause tumor cell mobilization and haematological effects such as increased lymphocytes, decreased platelet count, and splenic rupture in some patients. Hence, inform your oncologist about your complete medical history, including current medication, to rule out any side effects/interactions.

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