Besence Tablet is used for the management of neuropathic pain. Neuropathic pain is a chronic progressive nerve disease that causes nerve pain due to nerve damage or a malfunctioning nervous system. Symptoms of neuropathic pain include shooting, and burning pain followed by tingling and numbness (loss of sensation). Neuropathic pain can be caused by amputation of limbs, diabetic neuropathy (nerve damage due to excess blood sugar level), excessive alcohol intake (alcoholism) and cancer treatment via chemotherapy.

Besence Tablet is a combination of five drugs: Pregabalin (anticonvulsant), Methylcobalamin (vitamin B12), Benfotiamine (vitamin B1), Pyridoxine (vitamin B6) and Folic acid (vitamin B9). Pregabalin affects the chemicals in the brain that send pain signals to the nervous system, thereby relieving nerve pain and lowering the risk of seizures (fits). Methylcobalamin and Pyridoxine help rejuvenate and protect damaged nerve cells by producing a substance called myelin. Benfotiamine and Folic acid help deliver essential nutrients to the nerves. Together, Besence Tablet provides relief from neuropathic pain.

In some cases, Besence Tablet may cause side effects like dizziness, sleepiness, tiredness, nausea and vomiting. Most of these side effects of Besence Tablet do not require medical attention and resolve over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Please do not stop taking Besence Tablet without consulting your doctor, as it could cause withdrawal symptoms. Consult your doctor before taking Besence Tablet if you are pregnant or breastfeeding. Besence Tablet may cause drowsiness and dizziness, so drive only if you are alert. Besence Tablet should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with Besence Tablet as it could lead to increased dizziness and drowsiness. Keep your doctor informed about your health condition and the medicines you are taking to rule out any side effects.

Besence Tablet is a combination of five drugs: Pregabalin (anti-convulsant or antiepileptic), methylcobalamin (vitamin B12), benfotiamine (vitamin B1), pyridoxine (vitamin B6) and folic acid (vitamin B9). Besence Tablet is used to treat neuropathic pain. Pregabalin affects the chemicals in the brain that send pain signals to the nervous system, thereby relieving nerve pain and lowering the risk of seizures. Methylcobalamin and Pyridoxine help rejuvenate and protect damaged nerve cells by producing a substance called myelin. Benfotiamine and Folic acid help provide essential nutrients to the nerves. Together, Besence Tablet helps in providing relief from neuropathic pain.

• Nausea

• Vomiting

• Dizziness

• Drowsiness

• Fatigue

Do not take Besence Tablet if you are allergic to any of its contents. Inform your doctor before taking Besence Tablet if you have or had heart problems or bipolar syndrome. Please do not stop taking Besence Tablet without consulting your doctor as it could cause withdrawal symptoms. Consult your doctor before taking Besence Tablet if you are pregnant or breastfeeding. Besence Tablet may cause drowsiness, so drive only if you are alert. Besence Tablet should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with Besence Tablet as it could lead to increased dizziness and sleepiness. Consult your doctor immediately if you experience suicidal tendencies. Keep your doctor informed about your health condition and medicines to rule out any side effects. Besence Tablet can cause life-threatening breathing problems in patients with COPD and asthma. So a person with long pause breathing, blue coloured lips or sleeping disorder should inform the doctor before starting Besence Tablet .

Drug-Drug Interactions: Besence Tablet may have interaction with other anti-convulsant medications (gabapentin, phenobarbital, phenytoin), antidepressant medications (amitriptyline, duloxetine, mirtazapine, fluoxetine, sertraline), pain killer medications (codeine, fentanyl, hydrocodone, morphine, oxycodone, tramadol), anti-anxiety medications (diazepam, alprazolam), anti-diabetic medications (metformin), immunosuppressant medications (methotrexate), anti-rheumatoid medications (sulfasalazine), antibiotic medications (neomycin, chloramphenicol), anti-cancer medications (altretamine), and anti-Parkinson’s medications (levodopa).

Drug-Food Interactions: Avoid consumption of alcohol while taking Besence Tablet as it might cause increased dizziness and sleepiness.

Drug-Disease Interactions: Besence Tablet may have interactions with disease conditions such as suicidal tendency, chronic pulmonary insufficiency, heart problems, liver/kidney impairment angioedema, peripheral oedema, malabsorption and anaemia.

• PHENYTOIN
• CARBAMAZEPINE
• PHENOBARBITAL
• AMITRIPTYLINE
• DULOXETINE
• MIRTAZAPINE
• FLUOXETINE
• SERTRALINE
• CODEINE
• MORPHINE
• TRAMADOL
• FENTANYL
• OXYCODONE
• DIAZEPAM
• ALPRAZOLAM
• METFORMIN
• METHOTREXATE
• SULFASALAZINE
• NEOMYCIN
• CHLORAMPHENICOL
• ALTRETAMINE
• LEVODOPA

• Include food rich in vitamin B and D in your diet as these help with proper maintenance of nerve health.

• Include cayenne pepper in your diet as it can help in lowering neuropathic pain.

• Exercising regularly helps in improving overall health and combating pain.

• Rest well, get plenty of sleep.

• Try taking a warm bath as it can be soothing.

• Avoid smoking and alcohol consumption.

• Meditation and yoga can help lower stress, decrease pain sensitivity and improve coping skills.

• Acupuncture can be helpful by stimulating pressure points.

• Using essential oils for massages can help increase circulation.

• Besence Tablet contains Pregabalin, prolonged intake of pregabalin may lead to mental or physical dependence. Keep your doctor informed about your health condition.

• Besence Tablet may rarely cause serious side effects like suicidal thoughts, consult your doctor immediately if you face any such side effects.

Neuropathic pain: It is a nervous disorder that occurs due to nerve damage caused by chronic progressive nerve disease, limb amputation, diabetes or due to infection or injury. The pain could be intermittent or continuous, felt as a prickling, stabbing, tingling or burning sensation. A feeling of numbness and loss of senses is also common with neuropathic pain. Usually, the body sends the pain signals when there is an injury, but with neuropathic pain, the pain is not triggered by an injury. Symptoms include spontaneous, un-triggered pain, unpleasant feeling, shooting, burning or stabbing pain, difficulty resting or sleeping and evoked pain (pain caused by events that are usually not painful).