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Written By ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Nov 30, 2024 | 3:18 PM IST

Avinerve-D Capsule 10's is used in the treatment of diabetic neuropathic pain and fibromyalgia. It contains Pregabalin and Duloxetine. Pregabalin belongs to an anticonvulsant class of drugs, whereas Duloxetine is a selective serotonin reuptake (SSRI) inhibitor. This medicine mainly works by increasing the chemical messengers in the brain responsible for regulating pain. Avinerve-D Capsule 10's may cause certain side effects such as nausea, constipation, headache, dry mouth, increased sweating, loss of appetite, dizziness, and burning sensation.

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Prescription drug

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Synonym

DULOXETINE HYDROCHLORIDE+PREGABALIN

Manufacturer/Marketer

Aviator Life Science Pvt Ltd

Consume Type

ORAL

Return Policy

Not Returnable

for this medicine

About Avinerve-D Capsule 10's

Avinerve-D Capsule 10's belongs to an anticonvulsant class of medicines. It is used in the treatment of diabetic neuropathic pain and fibromyalgia. Neuropathic pain/ peripheral neuropathy is pain that occurs when the nervous system is not working properly or is damaged. Diabetic neuropathic pain/diabetic neuropathy is a condition causing moderate to severe pain due to damage of nerves in the thigh, hip, buttock and leg regions. Symptoms may include tingling, shooting pain, burning, or even an electric shock sensation. Fibromyalgia is a chronic condition with moderate pain and tenderness all over the body resulting in fatigue and trouble sleeping.

Avinerve-D Capsule 10's is a combination of Pregabalin and Duloxetine. Pregabalin belongs to an anticonvulsant class of drugs, whereas Duloxetine is a selective serotonin reuptake (SSRI) inhibitor. This medicine mainly works by increasing the chemical messengers in the brain responsible for regulating pain.

Avinerve-D Capsule 10's can be taken with or without food or as prescribed by your doctor. Avinerve-D Capsule 10's may cause certain side effects such as nausea, constipation, headache, dry mouth, increased sweating, loss of appetite, dizziness, and burning sensation. These side effects do not require medical attention and gradually resolve over time. However, if any of these side effects persist, inform your doctor.

Avinerve-D Capsule 10's should be avoided if you are allergic to it. Inform your doctor if you have any liver or kidney disease, seizures (fits), mania, bipolar disorder, glaucoma (an eye condition), bleeding disorders, or are at risk of hyponatremia (low sodium levels, especially in patients taking diuretics or water pills). If you are pregnant or breastfeeding, inform your doctor before taking this medicine. It is not recommended for use in children and young adults as it increases the risk of suicidal tendencies. 

Uses of Avinerve-D Capsule 10's

Treatment of Diabetic Neuropathic Pain and Fibromyalgia

Medicinal Benefits

Avinerve-D Capsule 10's contains Pregabalin and Duloxetine. Pregabalin belongs to an anticonvulsant class of drugs, whereas Duloxetine is a selective serotonin reuptake (SSRI) inhibitor. This medicine mainly works by increasing the chemical messengers in the brain responsible for regulating pain. Avinerve-D Capsule 10's effectively treats neuropathic pain, and improves nerve conduction for proper nerve signal functioning in the body. 

Directions for Use

Take Avinerve-D Capsule 10's as prescribed by your doctor. Swallow it as a whole with water. It can be taken with or without food. Do not crush, break or chew it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Avinerve-D Capsule 10's

  • Burning sensation
  • Drowsiness
  • Nausea
  • Constipation
  • Headache
  • Dry mouth
  • Increased sweating
  • Loss of appetite

Drug Warnings

Avinerve-D Capsule 10's should be avoided if you are allergic to any of the components in it. Do not stop taking Avinerve-D Capsule 10's suddenly without your doctor’s advice, as it may cause withdrawal symptoms like dizziness, tingling sensation, sleep disturbances, restlessness, nausea or vomiting, headache, or excessive sweating. Inform your doctor if you have any liver or kidney disease, seizures (fits), mania, bipolar disorder, or glaucoma (an eye condition). Avinerve-D Capsule 10's may increase suicidal thoughts, so it is advised to use caution in patients with mania, bipolar disorder or depression. It is not recommended for use in children below 18 years of age as the safety and efficacy of this medicine are not established. Pregnant or breastfeeding mothers should inform the doctor before using Avinerve-D Capsule 10's.

Drug Interactions

Drug-Drug Interactions: Avinerve-D Capsule 10's may interact with antidepressants (moclobemide, paroxetine, fluoxetine, venlafaxine, clomipramine, and amitriptyline), antibiotic (linezolid), opioid analgesic (tramadol).

Drug-Food Interactions: Avoid alcohol consumption and smoking while using Avinerve-D Capsule 10's.

Drug-Disease Interactions: Avinerve-D Capsule 10's should be used with caution in patients with liver diseases, kidney diseases, heart problems, glaucoma (increased pressure in the eye), alcoholism, drug abuse, and suicidal tendencies.

Drug-Drug Interactions Checker List

  • TRAMADOL
  • FLUOXETINE
  • MOCLOBEMIDE
  • VENLAFAXINE
  • AMITRIPTYLINE

Habit Forming

Yes

Diet & Lifestyle Advise

  • Exercise regularly, which helps in reducing pain.
  • Rest well, and get enough sleep.
  • Always take a warm bath, as it can be soothing.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower stress, decrease pain sensitivity, and improve coping skills.

Special Advise

  • Do not stop taking Avinerve-D Capsule 10's suddenly, as it may cause withdrawal symptoms.
  • Do frequent blood tests to check your fasting blood glucose, HbA1c, and total cholesterol (TC) levels to reduce any serious side effects.

Disease/Condition Glossary

Diabetic Neuropathy: Diabetic neuropathic pain/diabetic neuropathy is a condition causing moderate to severe pain due to damage of nerves in the thigh, hip, buttock and leg regions. Symptoms may include tingling, shooting pain, burning, or even an electric shock sensation. It mainly occurs in patients suffering from Type II Diabetes.

Fibromyalgia: It is a chronic condition with moderate pain and tenderness of the muscle all over the body. It mainly occurs due to physical or psychological stress. Symptoms may include fatigue, tiredness, trouble sleeping, anxiety, headache and depression.

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Alcohol

Unsafe

Avoid alcohol consumption during treatment with $nmae as it may increase the risk of serious side effects and worsen your health.

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Pregnancy

Caution

If you are pregnant, especially in the last trimester or planning pregnancy, inform your doctor before taking Avinerve-D Capsule 10's. It may cause foetal abnormalities if taken in the last trimester of pregnancy. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

If you are breastfeeding, inform your doctor before taking Avinerve-D Capsule 10's. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Unsafe

Avinerve-D Capsule 10's may cause drowsiness. Hence, avoid driving vehicles or operating machines after taking Avinerve-D Capsule 10's.

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Liver

Caution

If you have liver conditions, inform your doctor before taking Avinerve-D Capsule 10's. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have kidney conditions, inform your doctor before taking Avinerve-D Capsule 10's. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Avinerve-D Capsule 10's is not recommended for children below 18 years as the safety and efficacy of use for this medicine are not established. Please seek medical advice for more information.

Country of origin

India

Manufacturer/Marketer address

Bapunagar, Ahmedabad-380024, Gujarat, India
Other Info - AVI0179

FAQs

Avinerve-D Capsule 10's is used in the treatment of diabetic neuropathic pain and fibromyalgia. This medicine mainly works by increasing the chemical messengers in the brain responsible for regulating pain.
Do not stop using Avinerve-D Capsule 10's suddenly as it can cause withdrawal symptoms. Your doctor will gradually reduce the dose based on your clinical condition.
Seek medical attention immediately if you notice any depressive thoughts while using Avinerve-D Capsule 10's. Your doctor may change the dose or medicine to treat your condition.
Neuropathic pain/ peripheral neuropathy is pain that occurs when the nervous system is not working properly or is damaged.
Avinerve-D Capsule 10's contains Pregabalin and Duloxetine. Pregabalin is an anticonvulsant drug, whereas Duloxetine is a selective serotonin reuptake (SSRI) inhibitor. Both medicines mainly work by increasing the chemical messengers in the brain responsible for regulating pain.
To manage weight gain associated with the use of Avinerve-D Capsule 10's, maintain a balanced diet and engage in regular exercise. Use the lowest effective dose to help reduce the chances of gaining weight. Keep track of your weight and consult your doctor if you notice significant changes. They can help adjust your treatment or suggest ways to manage your weight more effectively.
Avinerve-D Capsule 10's may cause sleepiness or drowsiness in some individuals as a mild side effect. If you experience these symptoms, it is important to avoid activities that require full alertness, such as driving or operating machinery. If drowsiness persists for a longer period, please consult your doctor.
Avinerve-D Capsule 10's may take several weeks or longer to show its full effects. While some patients may notice improvements within the first week, it is important to continue taking the medication as prescribed to achieve the full benefits. Your doctor will likely reduce your dose gradually to avoid withdrawal symptoms.
If you forget to take Avinerve-D Capsule 10's, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
No, taking a higher dose of Avinerve-D Capsule 10's than recommended will not necessarily make it more effective and may increase the risk of side effects. Additionally, it can become habit-forming if misused or taken in larger amounts than prescribed for a prolonged period, leading to dependence. If you feel your current dose is not effective, please consult your doctor for proper adjustments, rather than increasing the dose on your own.
It is not recommended to drink alcohol while taking Avinerve-D Capsule 10's, as it may increase the risk of side effects such as drowsiness and dizziness. These effects impair your ability to perform tasks that require focus, so avoid driving or operating machinery while taking Avinerve-D Capsule 10's. Always consult your doctor for personalized advice.
Avinerve-D Capsule 10's should typically be stored in a cool and dry place, away from direct sunlight and moisture. Keep it out of reach of children.
Avinerve-D Capsule 10's may cause common side effects such as nausea, constipation, headache, dry mouth, increased sweating, loss of appetite, dizziness, and burning sensation. These side effects do not require medical attention and gradually resolve over time. However, if any of these side effects persist or worsen, please inform your doctor.

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