Appgest 40 Tablet is used as a symptomatic treatment in patients with breast cancer and endometrial cancer. Breast cancer develops in cells of the breast cells and is characterized by a lump in the breast, a change in the shape of the nipple or breast, and bloody discharge from the nipples. Endometrial cancer is the cancer of the womb's lining (uterus), characterized by pelvic pain, bleeding between periods, and pain during sex.

Appgest 40 Tablet contains ‘Megestrol’, which belongs to the class of ‘Progestogens’. It works similarly to the female hormone ‘progesterone’. It interferes with the production or action of hormones involved in cancer growth. This effect helps to slow down the progression of cancer and reduce the symptoms associated with cancer.

You should take this medicine exactly as your doctor prescribed. The common side-effects of Appgest 40 Tablet are an increase in appetite, weight gain, shortness of breath, hot flushes (reddening of the face and neck), high blood pressure, increased blood sugar levels, rounded face, constipation, and swelling of a vein due to a blood clot. If any of these side effects persist or get worse, inform your doctor immediately.

Do not take Appgest 40 Tablet if allergic to Megestrol or any contents. Before taking Appgest 40 Tablet , inform your doctor if you have severe liver problems, a history of thrombophlebitis (blood clots), stroke, adrenal gland disorder, and diabetes. Appgest 40 Tablet should be used with caution in elderly patients. Appgest 40 Tablet is not recommended for children, pregnant women, and breastfeeding mothers. Do not consume alcohol, as it may increase the risk of side effects. Appgest 40 Tablet may not affect your ability to drive.

Appgest 40 Tablet contains Megestrol, which is used to treat breast and endometrial cancer. It acts by interfering with the production of hormones that cause cancer's development. It helps to reduce cancer symptoms effectively. It can also be used to treat loss of appetite in patients with HIV/AIDS.

• Increase in appetite
• Weight gain
• Shortness of breath
• Hot flushes (reddening of the face and neck)
• High blood pressure
• Increased blood sugar levels
• Rounded face
• Constipation
• Swelling of a vein due to a blood clot

Appgest 40 Tablet increases the risk of blood clots, so it should be used cautiously in patients with a history of thrombophlebitis. Also, if you notice impaired coordination, difficulty speaking, pain in the groin, pain in the arm or leg (especially in the calf of the leg), shortness of breath, general weakness, headache, and dizziness, inform your doctor immediately as it may be a sign of blood clot. Appgest 40 Tablet is not recommended for use in pregnancy. Use a reliable contraceptive method to prevent pregnancy while using this medicine. You may also need to take a pregnancy test before using this medicine. Appgest 40 Tablet contains lactose, so inform your doctor if you have an intolerance to any sugars.

Drug-Drug Interactions: Appgest 40 Tablet may interact with a medicine used to treat heart rhythm disorders (dofetilide) and an anticoagulant (warfarin).

Drug-Food Interactions: No interactions found.

Drug-Disease Interactions: Appgest 40 Tablet should be used with caution in patients with severe liver problems, a history of thrombophlebitis (blood clots), stroke, adrenal gland disorder, and diabetes.

• DOFETILIDE
• WARFARIN

• Eat a healthy diet. Avoid fast food, fried food, processed meats, refined carbs, and added sugar.
• Drink plenty of fluids and eat fibre-rich food to prevent constipation.
• Manage your weight. Shed excess weight by exercising regularly if you are obese or overweight.
• Wear loose, layered clothing during the nighttime, especially in warm weather. This prevents hot flushes.
• Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs, and spices.
• Get optimal sleep; rest well.
• Avoid smoking and alcohol consumption.

• If you are undergoing surgery, inform your doctor that you are taking Appgest 40 Tablet as it may interfere with healing.
• Please do not stop taking Appgest 40 Tablet without discussing it with your doctor.
• Your doctor may advise you to monitor blood pressure regularly and take blood tests to evaluate liver and kidney function while using Appgest 40 Tablet .

Breast cancer: It is a type of cancer that develops in breast cells. Breast cancer may form in lobules (glands that produce milk), ducts of the breast (the pathway that brings milk from glands to the nipple), fatty tissue, or the fibrous connective tissue within the breast. Symptoms include a lump in the breast or tissue thickening which feels different than the normal surrounding tissues, breast pain, redness, swelling, nipple discharge other than breast milk, bloody discharge, unexplained change in shape, size, or appearance of the breast, peeling, flaking or scaling of the skin, and a lump or swelling under the arm.  The risk factors of breast cancer are increasing age, family history of breast cancer, and obesity.

Endometrial cancer: It is a type of cancer in which the endometrium (lining of the womb or uterus) is affected. It is usually seen in women above the age of 55 years. Symptoms include bleeding between periods, pelvic pain, and pain during sexual intercourse. Endometrial cancer risk factors are increasing age, obesity, never been pregnant, family history of cancer, and diabetes. This condition is not life-threatening when it is diagnosed and treated in the early stages.