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Written By ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Sep 30, 2024 | 4:52 PM IST

Aposan 10 mg Injection 5 ml is used to treat Parkinson's disease in adults. It contains Apomorphine, which works by mimicking the action of dopamine (acting in place of dopamine), a natural substance found in the brain needed to control body movement. Aposan 10 mg Injection 5 ml may cause side effects, such as sleepiness, yawning, nausea, vomiting, dizziness, hallucinations, injection site reactions, and leg swelling.

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Prescription drug

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Composition

APOMORPHINE-10MG

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Apr-26

for this medicine

About Aposan 10 mg Injection 5 ml

Aposan 10 mg Injection 5 ml belongs to a class of drugs called dopamine agonists. It is used for the acute, intermittent treatment of hypomobility, and off-episodes associated with Parkinson’s disease. Parkinson’s disease is a progressive neurological disorder in which the first signs are problems with movements.

Aposan 10 mg Injection 5 ml contains Apomorphine, which belongs to the class of non-ergoline dopamine agonists. It works by mimicking the action of dopamine (acting in place of dopamine), a natural substance found in the brain needed to control body movement.

Aposan 10 mg Injection 5 ml may cause certain side effects such as sleepiness, yawning, nausea, vomiting, dizziness, hallucinations, injection site reactions, and leg swelling. Most of these side effects do not require medical attention and will resolve gradually over time. Aposan 10 mg Injection 5 ml will be administered by a trained healthcare doctor.

Inform your doctor if you develop any allergic reactions after receiving Aposan 10 mg Injection 5 ml. It is advised not to stop Aposan 10 mg Injection 5 ml on your own. Consult your doctor if you are pregnant or breastfeeding. Always try to get up slowly from sitting or lying position as Aposan 10 mg Injection 5 ml may cause orthostatic hypotension (sudden lowering in blood pressure leading to dizziness on standing). Aposan 10 mg Injection 5 ml is not recommended for use in children below 18 years of age.

Uses of Aposan 10 mg Injection 5 ml

Treatment of Parkinson's disease

Medicinal Benefits

Aposan 10 mg Injection 5 ml belongs to a group of dopamine agonists used to treat Parkinson’s disease in adults. Aposan 10 mg Injection 5 ml works by stimulating the dopamine receptors in the brain. This triggers the nerve impulses in the brain that control body movements. Dopamine is a naturally occurring neurotransmitter in the brain which is absent or reduced in people with Parkinson’s disease.

Directions for Use

Aposan 10 mg Injection 5 ml will be administered by a trained healthcare doctor. Hence, do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Aposan 10 mg Injection 5 ml

  • Nausea
  • Low blood pressure
  • Dizziness
  • Constipation
  • Fatigue
  • Headache
  • Dry mouth
  • Muscle spasms
  • Injection site reactions
  • Pain at the site of injection

Drug Warnings

To treat your condition effectively, continue receiving Aposan 10 mg Injection 5 ml for the period that your doctor has prescribed. Do not take Aposan 10 mg Injection 5 ml if you are allergic to any of its contents. Talk to your doctor if you have any history of kidney/liver problems, hallucinations, dystonia (inability to keep the neck straight), depression, psychosis, vision impairment, and heart disease before receiving Aposan 10 mg Injection 5 ml. Aposan 10 mg Injection 5 ml may cause dyskinesia (abnormal limb movements), falling asleep frequently, prolonged QT intervals, hallucinations, syncope, haemolytic anaemia, impulsive behaviour, and coronary problems in some patients. Hence, inform your doctor if you experience symptoms such as anxiety, depression, fatigue, sweating or pain after dose reduction or stopping the medicine. Aposan 10 mg Injection 5 ml may cause drowsiness and dizziness; do not drive unless you are alert. Aposan 10 mg Injection 5 ml should not be given to children below 18 years. Avoid consuming alcohol along with Aposan 10 mg Injection 5 ml as it may cause increased drowsiness and dizziness. Always try to get up slowly from sitting or lying position as Aposan 10 mg Injection 5 ml causes orthostatic hypotension (sudden lowering in blood pressure leading to dizziness on standing).

Drug Interactions

Drug-Drug Interactions: Aposan 10 mg Injection 5 ml may interact with dopamine antagonists (amisulpride, metoclopramide, haloperidol, droperidol), antihypertensive drugs (benazepril, lisinopril, losartan, diltiazem, hydralazine), etc.

Drug-Food Interactions: Avoid smoking and alcohol consumption.

Drug-Disease Interactions: Inform your doctor if you have disease conditions such as low blood pressure, psychosis, and liver/kidney disorders.

Drug-Drug Interactions Checker List

  • AMISULPRIDE
  • DILTIAZEM
  • LISINOPRIL
  • BENAZEPRIL
  • HALOPERIDOL
  • DROPERIDOL
  • METOCLOPRAMIDE

Habit Forming

No

Diet & Lifestyle Advise

  • Maintain a healthy diet and exercise regularly.
  • Include a diet rich in iron, folate and magnesium. 
  • Regularly attend therapy sessions.
  • Perform meditation and yoga.
  • Follow a regular sleep pattern.
  • Avoid smoking and alcohol consumption.
  • Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

Special Advise

  • Patients and their caretakers (midwife/nurse) should be alerted as Aposan 10 mg Injection 5 ml may cause intense urges such as gambling, overeating and wasting money.
  • Aposan 10 mg Injection 5 ml should not be stopped suddenly as it may cause withdrawal symptoms.

Disease/Condition Glossary

Parkinson’s disease: It is a progressive neurological disorder which causes a problem with movements. Dopamine is a naturally occurring neurotransmitter in the brain which is reduced or absent in people with Parkinson’s disease. This causes difficulty during movements. Symptoms include decreased ability to smell, stooped posture, changes in voice, constipation, small/cramped handwriting, tremors, slow movements, stiffness of arms, legs, and trunk, and problems with balance.

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Aposan 10 mg Injection 5 ml as it may cause increased dizziness.

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Pregnancy

Caution

Studies on humans or animals have not determined whether apomorphine is safe to use while pregnant. It is, therefore, not appropriate for women who are pregnant or who are likely to become pregnant to use Aposan 10 mg Injection 5 ml. Inform your doctor if you are pregnant.

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Breast Feeding

Caution

The excretion of apomorphine in breast milk is unknown despite the lack of reported issues in humans. However, considering the advantages of both breastfeeding and medicine for the mother, a decision should be made regarding whether to stop breastfeeding or take the medication. Hence, inform your doctor if you are breastfeeding before taking Aposan 10 mg Injection 5 ml.

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Driving

Unsafe

Aposan 10 mg Injection 5 ml may cause dizziness, sleepiness and hallucinations. Avoid driving and handling machinery if you experience these symptoms.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before taking Aposan 10 mg Injection 5 ml. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before taking Aposan 10 mg Injection 5 ml. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Aposan 10 mg Injection 5 ml is not recommended for use in children below 18 years of age as the safety and efficacy are not established.

Country of origin

India

Manufacturer/Marketer address

58-D, Government Industrial Estate, Charkop, Kandivli (W), Mumbai 400 067 (India).
Other Info - APO0155

FAQs

Aposan 10 mg Injection 5 ml is used to treat Parkinson’s disease.
Aposan 10 mg Injection 5 ml works by acting like dopamine and triggering the nerve impulses in the brain that control our body movements.
Aposan 10 mg Injection 5 ml may cause peripheral oedema (swelling of the lower legs and hands due to fluid overload). So, avoid sitting or standing for too long.

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