Amfosted 500 Injection belongs to the class of cytoprotective agents. It is used in reducing cumulative renal toxicity associated with repeated administration of cisplatin in patients with advanced ovarian cancer. It is also used for the reduction of the incidence of moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer.

Amfosted 500 Injection contains Amifostine, which belongs to the class of protective agents. It works by protecting the kidneys in patients undergoing chemotherapy and radiation therapy.

Amfosted 500 Injection may cause certain side effects such as nausea, vomiting, pain at the site of injection, and injection site reactions. Inform your doctor if any of these side effects persist for longer. Amfosted 500 Injection will be administered by your physician in the hospital. Do not self-administer.

Avoid receiving Amfosted 500 Injection and inform your doctor if you are allergic to it or any other components of it. Before taking Amfosted 500 Injection, tell your doctor if you have/had liver or kidney disease, cardiac problems, skin disorders, and low calcium levels. This medicine is known to cause embryo-fetal toxicity. Hence, it is not recommended for use in pregnancy. Avoid breastfeeding while taking this Amfosted 500 Injection.

Amfosted 500 Injection contains Amifostine, which is used in protecting kidneys from renal toxicity associated with repeated administration of cisplatin in patients with advanced ovarian cancer. It is a cytotoxic medicine that detoxifies the reactive metabolites of platinum and alkylating agents.

• Nausea
• Vomiting
• Pain at the site of injection
• Allergic reactions
• Injection site reactions

To treat your condition effectually, continue receiving Amfosted 500 Injection for the period that your doctor has prescribed. Amfosted 500 Injection may cause severe cutaneous reactions, hypotension, cardiovascular problems, nausea, vomiting, and hypocalcemia. Therefore, caution should be exercised if you have/had liver or kidney disease, heart problems, and skin disorders while receiving Amfosted 500 Injection. This medicine may also cause severe hypersensitivity reactions. Hence, careful monitoring is recommended and discontinue the treatment if any severe allergic reactions occur. Inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment, as this medicine is known to cause embryo-fetal toxicity. Breastfeeding should be discontinued in nursing mothers during the treatment as it passes into breast milk and may cause a possible risk to the infant. This medicine is not recommended for use in children as the safety and efficacy are not established. 

Drug-Drug Interactions: Amfosted 500 Injection may have interaction with antihypertensive drugs, calcimimetic drugs (etelcalcetide),

Drug-Food Interactions: No interactions found.

Dug-Disease Interactions: Tell your doctor if you have kidney disease, heart problems, hypotension, skin disorders, or hypocalcaemia before starting the treatment.

• METOPROLOL
• AMLODIPINE
• ETELCALCETIDE
• CILNIDIPINE
• SPIRONOLACTONE

• Physical activity helps strengthen muscles, reduces fatigue, helps in weight loss, and gives strength. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
• Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
• Getting adequate sleep as resting helps improve your health and mental ability and improves attention.
• De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
• Eat food rich in antioxidants such as berries, spinach, etc.
• Foods containing fibre help in better digestion. These include beans, peas, lentils, whole grains, nuts, and seeds.
• Avoid smoking and alcohol consumption.
• Maintain a healthy weight.

• Your doctor may suggest periodic blood test to monitor the function of the kidney and calcium levels due to the use of Amfosted 500 Injection.
• Using contraceptive pills while using Amfosted 500 Injection to prevent pregnancy is advised.
• Regular blood pressure monitoring is recommended during the treatment course to check for any changes in cardiovascular events.

Ovarian cancer: It is a common type of cancer that occurs when abnormal cells in the ovary begin to multiply out of control and form a tumor. If left untreated, the tumor can spread to other parts of the body (metastasis). This is called metastatic ovarian cancer. Symptoms may include abdominal bloating, pressure, pain, abnormal fullness after eating, difficulty eating, increased urination, and an increased urge to urinate.