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Synonym

EPIRUBICIN HYDROCHLORIDE

Composition

EPIRUBICIN-100MG

Manufacturer/Marketer

Alkem Laboratories Ltd

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Jan-25

for this medicine

About ALRUBICIN 100MG INJECTION

ALRUBICIN 100MG INJECTION is an anti-cancer medicine that is used in conjunction with other drugs to treat breast cancer in people who have had tumor removal surgery. ALRUBICIN 100MG INJECTION is used as adjuvant chemotherapy in women with axillary lymph nodes with involvement resection of breast cancer (abnormal growth in the cells of the breast).

ALRUBICIN 100MG INJECTION contains Epirubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis.

ALRUBICIN 100MG INJECTION may cause certain side effects such as nausea, headache, abdominal pain, loss of appetite, vomiting, dizziness, mouth sores, tiredness, back pain, diarrhoea, and pain at the site of injection. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor. A trained healthcare doctor will administer ALRUBICIN 100MG INJECTION. So, do not self-administer. Your doctor will decide the dose of the medicine based on your health condition.

ALRUBICIN 100MG INJECTION should be avoided if you are allergic to it. It is contraindicated in patients having a recent history of myocardial infarction (MI) or heart attack, patients with baseline neutrophil count < 1500 cells/mm3, severe arrhythmias, previous treatment with anthracyclines, and severe hepatic dysfunction. Hence avoid using this medicine under such conditions. Inform your doctor if you have any cardiovascular conditions, liver/kidney disease, or taking any medicines such as cardiotoxic drugs (eg, Thalidomide, doxorubicin, Abiraterone, tamoxifen, letrozole), and cimetidine, as it can cause serious adverse effects. ALRUBICIN 100MG INJECTION is known to cause embryo-fetal toxicity. Hence it is contraindicated in pregnant or breastfeeding women. ALRUBICIN 100MG INJECTION is not recommended for children as it is known to cause anthracycline-induced acute manifestations of cardiotoxicity and chronic CHF.

Uses of ALRUBICIN 100MG INJECTION

Treatment of Breast Cancer

Medicinal Benefits

ALRUBICIN 100MG INJECTION contains Epirubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis. It is used as adjuvant chemotherapy in women with axillary lymph nodes with involvement resection of breast cancer.

Side Effects of ALRUBICIN 100MG INJECTION

  • Nausea
  • Abdominal pain
  • Vomiting
  • Dizziness
  • Back pain
  • Pain at the site of injection
  • Red discoloration of urine
  • Loss of appetite
  • Mouth sores
  • Tiredness
  • Weight gain
  • Pale skin

Directions for Use

A trained healthcare professional will administer ALRUBICIN 100MG INJECTION. Hence, do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

ALRUBICIN 100MG INJECTION should be avoided if you are allergic to it. It is contraindicated in patients having a recent history of myocardial infarction (MI) or heart attack, patients with baseline neutrophil count < 1500 cells/mm3, severe arrhythmias, previous treatment with anthracyclines and severe hepatic dysfunction. Hence avoid using this medicine under such conditions. Inform your doctor if you have any cardiovascular conditions, liver/kidney disease, or taking any medicines such as cardiotoxic drugs (e.g., Thalidomide, doxorubicin, Abiraterone, tamoxifen, letrozole), and cimetidine, as it can cause serious adverse effects. ALRUBICIN 100MG INJECTION is known to cause embryo-fetal toxicity. Hence it is contraindicated in pregnant or breastfeeding women. ALRUBICIN 100MG INJECTION is not recommended for children as it is known to cause anthracycline-induced acute manifestations of cardiotoxicity and chronic CHF. Do not stop receiving ALRUBICIN 100MG INJECTION without a doctor’s advice, as it can cause serious health conditions. ALRUBICIN 100MG INJECTION is known to cause severe life-threatening haematological reactions, tissue necrosis, cardiomyopathy, secondary acute myelogenous leukaemia, and severe myelosuppression in some patients. Hence careful monitoring of the patient is needed while receiving the medicine.

Therapeutic Class

ANTINEOPLASTIC

Drug Interactions

Drug-Drug Interactions: ALRUBICIN 100MG INJECTION may interact with cardiotoxic drugs (e.g., Thalidomide, doxorubicin, Abiraterone, tamoxifen, letrozole), antimicrotubular agents ((paclitaxel, docetaxel), antihistamine (cimetidine), calcium channel blockers (cilnidipine, nifedipine).

Drug-Food Interactions: Avoid smoking and alcohol consumption.

Drug-Disease Interactions: Inform your doctor if you have cardiac problems, liver or kidney disease, heart attack, severe MI, or cardiomyopathy.

Drug-Drug Interactions Checker List

  • THALIDOMIDE
  • DOXORUBICIN
  • ABIRATERONE
  • TAMOXIFEN
  • LETROZOLE
  • PACLITAXEL
  • DOCETAXEL
  • CIMETIDINE
  • CILNIDIPINE
  • NIFEDIPINE

Diet & Lifestyle Advise

  • Try to eat more healthy fats, fruits, vegetables and whole-grain foods to give you more energy. 
  • Stay hydrated by drinking plenty of water, as dehydration is often seen in cancers.
  • Taking a stroll in the garden or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid smoking and alcohol consumption.
  • Doing meditation and yoga for some time is very effective in helping cancer patients maintain a healthy attitude and body.

Habit Forming

No

What if I have taken an overdose of ALRUBICIN 100MG INJECTION

Since ALRUBICIN 100MG INJECTION is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly. Overdose of ALRUBICIN 100MG INJECTION may cause sores in the mouth and throat, fever, sore throat, chills, or other signs of infection, unusual bleeding or bruising, black and tarry stools, red blood in stools, and bloody vomit or vomited material that looks like coffee grounds.

Special Advise

  • Avoid having intercourse while on treatment with ALRUBICIN 100MG INJECTION.
  • Regular monitoring of complete blood count  (CBC) and liver function (LFT) is important while receiving ALRUBICIN 100MG INJECTION.

Disease/Condition Glossary

Breast Cancer: Breast cancer is a type of cancer with abnormal growth in the cells of the breast. There are different kinds of breast cancer, such as cancer occurring in lobules (glands that produce milk), ducts of the breast (the pathway that brings milk from glands to the nipple), and in the fatty tissue or the fibrous connective tissue within the breast. Symptoms of breast cancer include a lump in the breast, breast pain, redness, swelling, nipple discharge other than breast milk, bloody discharge, a lump or swelling under the arm, unexplained change in shape, size or appearance of the breast, peeling, flaking or scaling of the skin.

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Alcohol

Unsafe

Alcohol intake might increase the risk of stomach or intestine bleeding. Alcohol consumption is not recommended.

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Pregnancy

Unsafe

ALRUBICIN 100MG INJECTION is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving ALRUBICIN 100MG INJECTION. Use reliable methods of birth control while on treatment with ALRUBICIN 100MG INJECTION.

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Breast Feeding

Unsafe

It is not recommended for use in breastfeeding as it may pass into breast milk and harm your infant. Hence, if you are breastfeeding, inform your doctor before receiving ALRUBICIN 100MG INJECTION. Your doctor may suggest you stop feeding while on treatment with this medicine.

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Driving

Safe

ALRUBICIN 100MG INJECTION does not affect your ability to drive. However, drive only if you are alert.

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Liver

Caution

ALRUBICIN 100MG INJECTION should be used with caution in patients with liver impairment. However, this medicine is contraindicated in patients with severe liver disease. If you have a pre-existing or a history of liver disease, inform your doctor. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor. Your doctor may adjust the dose or prescribe a suitable alternative, if necessary, based on your condition.

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Children

Unsafe

ALRUBICIN 100MG INJECTION is not recommended for use in children, as it is known to cause anthracycline-induced acute manifestations of cardiotoxicity and chronic CHF leading to serious side effects.

Country of origin

India

Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Other Info - ALR0004

FAQs

ALRUBICIN 100MG INJECTION is used to treat Breast Cancer.
ALRUBICIN 100MG INJECTION contains Epirubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis.
ALRUBICIN 100MG INJECTION can disrupt a woman's natural menstrual cycle (period) and inhibit sperm production in men. However, you should not presume that you cannot become pregnant or that you cannot make someone else pregnant. It may also harm your foetus. Use reliable methods of birth control while on treatment with ALRUBICIN 100MG INJECTION.
Yes, ALRUBICIN 100MG INJECTION is considered a vesicant. This means it may cause tissue blistering and damage if it leaks out of the vein during administration in some individuals. Hence, this medication must be administered by a trained healthcare professional to reduce the risk of this complication.
ALRUBICIN 100MG INJECTION is effective in treating breast cancer by slowing or stopping the growth of cancer cells. It inhibits the topoisomerase II enzyme, interfering with DNA replication and destroying cancer cells. However, like all medications, it can have side effects and interact with other drugs, so it's essential to follow your doctor's instructions to maximize effectiveness and minimize side effects.
ALRUBICIN 100MG INJECTION is a chemotherapy medication that contains the active ingredient Epirubicin, a type of anthracycline topoisomerase inhibitor, used to treat breast cancer after tumor removal surgery.
The common side effects of ALRUBICIN 100MG INJECTION may include nausea, headache, abdominal pain, loss of appetite, vomiting, dizziness, mouth sores, tiredness, back pain, diarrhoea, and pain at the injection site. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.

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Keep Refrigerated. Do not freeze.