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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Nov 23, 2024 | 4:48 PM IST
AFINITOR 10 MG TABLET is used to treat cancer and to prevent organ rejection. It contains Everolimus which works by stopping cancer cells from reproducing and decreasing the activity of the immune system. In some cases, this medicine may cause side effects such as weakness, infection, cough, diarrhoea, fever, and fatigue. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Prescription drug

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Prescription drug
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Composition

EVEROLIMUS

Manufacturer/Marketer

Novartis India Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About AFINITOR 10 MG TABLET

AFINITOR 10 MG TABLET belongs to the group of medicine called ‘anti-cancer’. It is primarily used to treat breast cancer, pancreatic cancer, lung cancer and kidney cancer. Breast cancer is a type of cancer that develops in breast cells stimulated by the female sex hormone known as estrogen. Pancreatic cancer is described as a cancerous growth in the pancreas which normally begins in the cells that generate the juices that help break down food and the hormones which help in controlling blood sugar levels. Lung cancer is the uncontrolled growth of abnormal cells in one or both lungs. 

AFINITOR 10 MG TABLET contains 'Everolimus' which belongs to the group of medicines known as 'kinase inhibitors'. It works by decreases the activity of the immune system of the body and prevents rejection of the transplanted organ. It works by stopping the action of an abnormal protein that causes the multiplication of cancerous cells. In this way, it stops the spread of cancerous cells.

Take AFINITOR 10 MG TABLET as prescribed by your doctor. You are advised to take AFINITOR 10 MG TABLET for as long as your doctor has prescribed it for you depending on your medical conditions. You may experience weakness, infection, sinus inflammation, cough, diarrhea, fever, fatigue, otitis media (infection of the ear), stomatitis (Inflammation of the mouth) and upper respiratory tract infection. Most of these side effects of AFINITOR 10 MG TABLET do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

To treat your condition effectually, continue taking AFINITOR 10 MG TABLET for as long as your doctor has prescribed. If you are known to be allergic to AFINITOR 10 MG TABLET or any other medicines, please tell your doctor. Do not take AFINITOR 10 MG TABLET if you are pregnant or planning for pregnancy as AFINITOR 10 MG TABLET may harm the unborn baby. AFINITOR 10 MG TABLET should not be taken by breastfeeding mothers as it may cause harm to the newborn baby. AFINITOR 10 MG TABLET causes tiredness, thus, it is advisable not to drive unless you are alert. Elderly people are more sensitive to medicine so they may adjust the dosage according to their condition.

Uses of AFINITOR 10 MG TABLET

Treatment of Breast cancer, pancreatic cancer, lung cancer and kidney cancer.

Medicinal Benefits

AFINITOR 10 MG TABLET is indicated to the patients dealing with breast cancer, pancreatic cancer, lung cancer, kidney cancer and stomach/ intestinal cancer. Cancer of this type tends to spread quickly in other parts of the body. AFINITOR 10 MG TABLET travels through the bloodstream and effectively destroys cancerous cells and other parts of the body. It works by decreases the activity of the immune system of the body and prevents rejection of the transplanted organ. It works by stopping the action of an abnormal protein that causes the multiplication of cancerous cells. In this way, it stops the spread of cancerous cells. Besides this, it is also effective in people with genetic disorders to treat some types of tumors in the brain or kidney.

Directions for Use

Take AFINITOR 10 MG TABLET with or without food as advised by the doctor. Swallow it as a whole with water; do not crush, break or chew it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of AFINITOR 10 MG TABLET

  • Tiredness
  • Breathlessness
  • Dizziness
  • Headache
  • Loss of appetite
  • Infection
  • Mouth ulcers 
  • Sinus inflammation
  • Cough
  • Diarrhea
  • Fever
  • High level of sugar in the blood (hyperglycemia)
  • Signs of low level of red blood cells (anemia) 
  • Otitis media (infection of the ear)
  • Stomatitis (Inflammation of the mouth)
  • Upper respiratory tract infection.
  • Swelling of arms, hands, feet, and ankles

Drug Warnings

If you are known to be allergic to AFINITOR 10 MG TABLET or any other medicines, please tell your doctor. AFINITOR 10 MG TABLET should not be taken in the conditions like liver disease, diabetes and high level of cholesterol. Do not take AFINITOR 10 MG TABLET if you have recent surgery, infection and hepatitis B. AFINITOR 10 MG TABLET may weaken your immune system, inform your doctor before taking AFINITOR 10 MG TABLET . AFINITOR 10 MG TABLET may also impair your kidney function. Therefore, monitor your kidney function regularly while taking AFINITOR 10 MG TABLET . AFINITOR 10 MG TABLET may cause cough, fever and shortness of breathing, thereby inform your doctor while taking your AFINITOR 10 MG TABLET . AFINITOR 10 MG TABLET may cause skin cancer, if you observe night sweating, weight loss, or change in color and size of the mole inform your doctor. Do not take AFINITOR 10 MG TABLET if you are pregnant or planning for pregnancy as AFINITOR 10 MG TABLET may harm the unborn baby. AFINITOR 10 MG TABLET should not be taken by breastfeeding mothers as it may cause harm to the newborn baby. AFINITOR 10 MG TABLET causes tiredness, thus, it is advisable not to drive unless you are alert. Elderly people are more sensitive to medicine so they may adjust the dosage according to their condition.

Drug Interactions

Drug-Drug Interaction: AFINITOR 10 MG TABLET may have interaction with antifungal medicines (ketoconazole, itraconazole, voriconazole, fluconazole), antibiotics (clarithromycin, telithromycin, erythromycin), anti-HIV medicines (ritonavir, efavirenz), blood pressure-lowering medicines (ramipril, verapamil, diltiazem), medicines for heart disease (dronedarone), medicines for decreasing growth of abnormal cells (imatinib), medicines for fits/ epilepsy (phenytoin, carbamazepine, phenobarbital).

Drug-Food Interaction: Avoid grapefruits and grapefruit juice.

Drug-Disease Interaction: AFINITOR 10 MG TABLET should not be given to the patients with liver disease, kidney disease, diabetes, high level of cholesterol and infections.

Drug-Drug Interactions Checker List

  • KETOCONAZOLE
  • ITRACONAZOLE
  • VORICONAZOLE
  • CLARITHROMYCIN
  • TELITHROMYCIN
  • ERYTHROMYCIN
  • RITONAVIR
  • EFAVIRENZ
  • RAMIPRIL
  • VERAPAMIL
  • DILTIAZEM
  • DRONEDARONE
  • IMATINIB
  • PHENYTOIN
  • CARBAMAZEPINE
  • PHENOBARBITAL
  • FLUCONAZOLE

Habit Forming

No

Diet & Lifestyle Advise

  • Avoid smoking and alcohol consumption.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yogurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs and spices in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep, rest well.
  • Performing yoga and other relaxation techniques may also improve physical and mental health and may reduce your stress levels.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.

Special Advise

  • AFINITOR 10 MG TABLET should be taken under strict medical supervision. The doctor will regularly monitor your condition while taking AFINITOR 10 MG TABLET .
  • Do not have immunizations/vaccinations without a doctor's advice.
  • Avoid contact with people who have recently received live vaccines.

Disease/Condition Glossary

Breast cancer: It is a type of cancer that develops in breast cells that are stimulated by a female sex hormone called estrogen. Breast cancer may form in lobules (glands that produce milk), ducts of the breast (the pathway that brings milk from glands to the nipple), in the fatty tissue or the fibrous connective tissue within the breast. The tumor cells invade other healthy breast cells and can travel to lymph nodes which are a primary pathway for the cancer cells to move to other parts of the body. 

Lung cancer: It happens when cells in the lung begin to grow in an uncontrolled manner. The most common form of lung cancer is non-small cell lung cancer (NSCLC). It happens when cells that form the lining of the lung start growing uncontrollably. Persons who smoke are at high risk of lung cancer. A common symptom of lung cancer is a cough that does not go easily followed by shortness of breath. Cancerous cells of the lung spread off and travel through the bloodstream to distant regions of the body and grow.

Pancreatic cancer: It is described as a cancerous growth in the pancreas which normally begins in the cells that generate the juices. Juices are produced by the pancreas ( a gland present behind your stomach) help in the breakdown of food and hormones which help in controlling blood sugar levels.

Kidney cancer: Kidneys are the organs on either side of your backbone directly above your waist. The tubes present inside clean and filter your blood, taking out waste foods and making urine. Kidney cancer produces in the lining of tiny tubes inside your kidneys.

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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking AFINITOR 10 MG TABLET to avoid unpleasant side-effects.

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Pregnancy

Unsafe

AFINITOR 10 MG TABLET is belonging to pregnancy C category. It is not safe in pregnancy as it may causes harm to the unborn baby. Do not conceive a baby while taking AFINITOR 10 MG TABLET .

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Breast Feeding

Unsafe

AFINITOR 10 MG TABLET should not be taken by breastfeeding mothers as it may harm to the new-born baby.

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Driving

Caution

AFINITOR 10 MG TABLET may cause tiredness (fatigue), do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

AFINITOR 10 MG TABLET should be taken with caution in patients dealing with liver disease. The doctor may adjust the dose according to the medical condition of the patient.

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Kidney

Caution

AFINITOR 10 MG TABLET is likely unsafe in patients with severe kidney disease as it may cause kidney failure which can be dangerous, use AFINITOR 10 MG TABLET only when prescribed by a doctor.

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Children

Unsafe

AFINITOR 10 MG TABLET is not recommended for children below 18 years as the safety and effectiveness were not established.

Country of origin

India

Manufacturer/Marketer address

Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India
Other Info - AFI0010

Author Details

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FAQs

AFINITOR 10 MG TABLET is used to treat breast cancer, pancreatic cancer, lung cancer and kidney cancer.
AFINITOR 10 MG TABLET is an anticancer medicine. It belongs to a group of medicines known as a kinase inhibitor. It works by lowering the blood supply to the tumor, which reduces the growth and spread of cancer cells.
There is no specific duration of treatment with AFINITOR 10 MG TABLET . AFINITOR 10 MG TABLET is continued till benefit is seen or undesirable toxicity or side effects occur.
You should prevent grapefruit or grapefruit juice while taking AFINITOR 10 MG TABLET . This is because taking them together may rise the levels of AFINITOR 10 MG TABLET in your blood to toxic levels. Avoid the use of live vaccinations and any probable contact with people who have received live vaccinations.
AFINITOR 10 MG TABLET can lead to serious side effects that consist of severe allergic reactions, angioedema (painless swelling under the skin) and kidney failure which can be dangerous and can lead to death. It is possible that you may develop an infection or problems associated to lungs like breathing problems.
It usually takes three to six months for most types of lung cancer to double their size. It will take a long time for lung cancer to reach a size that could be diagnosed in X-Ray.
AFINITOR 10 MG TABLET contains Everolimus, which belongs to the group of medicines known as kinase inhibitors.
Regular monitoring is essential when using AFINITOR 10 MG TABLET . Your doctor may check your blood tests, blood sugar, blood pressure, and kidney function. They may also adjust your dose based on your response to treatment or any side effects that occur. It's essential to report any changes or concerns to your doctor to ensure safe and effective treatment.
While taking AFINITOR 10 MG TABLET , avoiding certain things is essential to ensure your safety. Avoid consuming grapefruit juice and products and St. John's Wort, as they can interact with the medication. Certain antibiotics, antifungals, and medications can also interact with Everolimus, so consult your doctor before taking any new medications. Additionally, consult your doctor before receiving any vaccinations and avoid high-risk activities that may increase the risk of infections and bleeding. It's also important to avoid getting pregnant or fathering a child while taking Everolimus, as well as breastfeeding. Finally, limit your sun exposure to avoid increasing the risk of skin cancer. Always consult your doctor or pharmacist for a comprehensive list of medications and activities to avoid while taking Everolimus.
Before using any medication, including AFINITOR 10 MG TABLET , you should know its purpose, usage, safety profile, precautions, and limitations.
AFINITOR 10 MG TABLET is administered orally in the form of a tablet. Take Everolimus with or without food, as advised by your doctor. Swallow the tablet whole with water; do not crush, break, or chew it. Note: It's important to follow your doctor's instructions and take AFINITOR 10 MG TABLET exactly as prescribed
By regularly monitoring your progress through brain scans and other evaluations, your doctor can determine if AFINITOR 10 MG TABLET is effectively shrinking your brain tumor.
AFINITOR 10 MG TABLET is indeed considered a cytotoxic medication, but it's a targeted therapy that specifically targets cancer cells and inhibits their growth. It's not a traditional chemotherapy medication, but it can still have side effects and be harmful to healthy cells to some extent. If you have any concerns or questions, please consult your doctor or healthcare team to discuss potential risks and benefits and manage any side effects.
Common side effects of AFINITOR 10 MG TABLET may include weakness, infection, sinus inflammation, cough, diarrhoea, fever, fatigue, otitis media (infection of the ear), stomatitis (Inflammation of the mouth) and upper respiratory tract infection. Most of these side effects of AFINITOR 10 MG TABLET do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

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