apollo
0
Reviewed By , MPharma., PhD
Last Updated Jan 1, 2025 | 9:32 AM IST

Afadel 40 mg Tablet is an anti-cancer medicine used in the treatment of non-small cell lung cancer (NSCLC). It contains Afatinib as an active ingredient, which belongs to the class of medicines known as kinase inhibitors. It works by stopping the action of an enzyme (tyrosine kinase) that causes the multiplication of cancerous cells. This helps prevent the abnormal growth of cancer cells and thus reduce their further spread to other parts of the body.

Read more
Prescription drug

Whats That

tooltip
Consult Doctor

Composition :

AFATINIB-40MG

Manufacturer/Marketer :

Adley Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Afadel 40 mg Tablet

Afadel 40 mg Tablet is an anti-cancer medicine used in the treatment of non-small cell lung cancer (NSCLC). It is a common form of lung cancer in which abnormal cells grow in the lung tissues. Afadel 40 mg Tablet is used as a first-line therapy in the treatment of metastatic NSCLC with non-resistant epidermal growth factor receptor (EGFR) mutations and in patients with metastatic, squamous NSCLC progressing after platinum-based chemotherapy.

Afadel 40 mg Tablet contains Afatinib as an active ingredient, which belongs to the class of medicines known as kinase inhibitors. It works by stopping the action of an enzyme (tyrosine kinase) that causes the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body.

Afadel 40 mg Tablet may cause certain side effects such as diarrhea, rash, decreased appetite, nausea, vomiting, dry skin, mouth sores, nail inflammation, ache, cough, abdominal pain, and itching. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. Afadel 40 mg Tablet should be taken as advised by your doctor. Do not take more than the recommended dose. Your doctor will decide the dose of Afadel 40 mg Tablet based on the severity of your condition.

Avoid taking Afadel 40 mg Tablet if you are allergic to it or any other components of it. Before taking Afadel 40 mg Tablet , inform your doctor if you have/had liver or kidney disease, eye problems, lung disease other than lung cancer, heart problems, and breathing difficulty. This medicine is known to cause embryo-fetal toxicity. It is not recommended for use in pregnancy and breastfeeding. Elderly people are more sensitive to medicine, so the dose may have to be adjusted according to their condition.

Uses of Afadel 40 mg Tablet

Treatment of Non-small cell lung cancer (NSCLC)

Medicinal Benefits

Afadel 40 mg Tablet contains Afatinib, which belongs to the class of medicines known as kinase inhibitors. It works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body. It also decreases the blood supply to cancer tumors to slow down the growth of the tumor.  In this way, Afadel 40 mg Tablet stops the body's production, spread and growth of cancerous cells.

Side Effects of Afadel 40 mg Tablet

  • Acne
  • Dry skin
  • Nausea
  • Vomiting
  • Diarrhoea
  • Loss of appetite
  • Itching or skin rash
  • Mouth sores
  • Cough
  • Nail inflammation
  • Visual disturbances
  • Abdominal pain

Directions for Use

Take Afadel 40 mg Tablet as prescribed by the doctor. It should be taken without food on an empty stomach at least one hour before or two hours after a meal. Swallow it as a whole with a glass of water. Do not crush, break, or chew it.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

To treat your condition effectually, continue taking Afadel 40 mg Tablet for the period that your doctor has prescribed. Avoid taking Afadel 40 mg Tablet if you are allergic to it or any other components present in it. Caution should be exercised if you have/had liver or kidney disease, eye problems, lung disease other than lung cancer, heart problems, severe cough, and breathing difficulty. This medicine is known to cause embryo-fetal toxicity. Hence, inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment. Afadel 40 mg Tablet may cause severe diarrhea, Bullous and exfoliative skin disorder, hepatotoxicity, Interstitial lung disease, and keratitis in some patients. Hence, inform your doctor about your complete medication and medical history before taking Afadel 40 mg Tablet . Breastfeeding should be discontinued in nursing mothers during the treatment as it passes into breast milk and may cause a possible risk to the infant. Avoid driving and operating machines, as this medicine may cause visual disturbances. This medicine is not recommended for use in children below 18 years of age as the safety and efficacy are not established.

Therapeutic Class

ANTINEOPLASTIC

Diet & Lifestyle Advise

  • Physical activity helps strengthen muscles, reduces fatigue, helps in weight loss, and gives strength. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Getting adequate sleep as resting helps improve your health and mental ability and improves attention.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Eat food rich in antioxidants such as berries, spinach, etc.
  • Foods containing fibre help in better digestion. These include beans, peas, lentils, whole grains, nuts, and seeds.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

How Afadel 40 mg Tablet Works

Afadel 40 mg Tablet contains Afatinib as an active ingredient, which belongs to the class of medicines known as kinase inhibitors. It works by stopping the action of an enzyme (tyrosine kinase) that causes the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body.

What if I have taken an overdose of Afadel 40 mg Tablet

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Afadel 40 mg Tablet are nausea, vomiting, weakness, dizziness, headache and stomach pain. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.
bannner image

Alcohol

Caution

Limit alcohol consumption while taking Afadel 40 mg Tablet .

bannner image

Pregnancy

Unsafe

Afadel 40 mg Tablet is not recommended for use in pregnancy as it may cause embryo-fetal toxicity and harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking Afadel 40 mg Tablet . You should not become pregnant while you are taking Afadel 40 mg Tablet and for at least two weeks after your treatment. Using effective birth control methods while on treatment with Afadel 40 mg Tablet is suggested.

bannner image

Breast Feeding

Unsafe

Afadel 40 mg Tablet should not be taken if you are breastfeeding as it passes into breast milk and may harm your infant.

bannner image

Driving

Unsafe

Do not drive, operate machinery, or engage in any activity that needs clear vision until you are confident that you can do so safely while you are on treatment with Afadel 40 mg Tablet .

bannner image

Liver

Caution

If you have a pre-existing or a history of liver problems, tell your doctor before taking this medicine. Afadel 40 mg Tablet is known to cause hepatotoxicity, which may be fatal. Hence, this medicine should be taken cautiously. Your doctor may suggest tests to monitor your liver function while on treatment with this medicine. Tell your doctor right away if you have any symptoms of a liver problem, which may include yellowing of your skin or the white part of your eyes (jaundice), dark or brown (tea-coloured) urine, pain on the upper right side of your stomach area (abdomen), bleeding or bruising more easily than normal, feeling very tired while taking Afadel 40 mg Tablet .

bannner image

Kidney

Caution

If you have a pre-existing or a history of kidney diseases, inform your doctor before receiving Afadel 40 mg Tablet . Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

bannner image

Children

Unsafe

Afadel 40 mg Tablet is not recommended for children below 18 years as the safety and effectiveness were not established.

Country of origin

India

Manufacturer/Marketer address

2/236, KAMBRATH THAZAM, PULLALUR, KURUVATTOOR PO, NA KOZHIKODE Kozhikode Kerala 673012
Other Info - AFA0012

Author Details

Doctor imageWe provide you with authentic, trustworthy and relevant information

FAQs

Afadel 40 mg Tablet is used to treat Non-small cell lung cancer (NSCLC).
Afadel 40 mg Tablet contains Afatinib, which works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells.
The most common sign of lung cancer is a cough that lasts long and gets worse with time. Sometimes, a patient may notice blood in the cough. Chest pain is also a sign of lung cancer, followed by coughing.
Afadel 40 mg Tablet is safe to be taken by a diabetic person. However, take Afadel 40 mg Tablet only after consulting with a doctor, as they may adjust the dosing according to your condition.
Afadel 40 mg Tablet is a chemotherapy drug used to treat non-small-cell lung cancer (NSCLC) that is caused by an abnormal epidermal growth factor receptor (EGFR) gene or genes.
Take Afadel 40 mg Tablet as prescribed by the doctor. It should be taken without food on an empty stomach at least one hour before or two hours after a meal. Swallow it as a whole with a glass of water. Do not crush, break, or chew it.
Afadel 40 mg Tablet is an anti-cancer medication that belongs to the class of kinase inhibitors used to treat non-small cell lung cancer (NSCLC).
Afadel 40 mg Tablet may affect fertility, as suggested by animal studies indicating reduced fertility in both men and women. If you plan to become pregnant or father a child, consult your doctor before taking this medication.
Yes, Afadel 40 mg Tablet may be given along with chemotherapy in some instances, but only under the careful guidance of a doctor, who will determine its suitability based on the stage and severity of individual cancer.
If you miss a dose of Afadel 40 mg Tablet , take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Afadel 40 mg Tablet is specifically used to treat non-small cell lung cancer (NSCLC) with certain genetic mutations (EGFR-positive). It is not a cure for all types of lung cancer.
When taking Afadel 40 mg Tablet , it's important to note that food can reduce the absorption of the medication, leading to lower blood levels and potentially reduced effectiveness. To minimize this effect, avoid eating for at least 1 hour before and 2 hours after taking Afadel 40 mg Tablet . Additionally, limit your sun exposure and take sun protection measures, such as using sunscreen and wearing protective clothing. You should also quit smoking, limit alcoholic beverages and avoid St. John's Wort preparations altogether. Furthermore, use effective contraception to prevent pregnancy or fathering a child while using Afadel 40 mg Tablet . Lastly, be sure to avoid certain medications that may interact with Afadel 40 mg Tablet . Following these guidelines can ensure safe and effective treatment with Afadel 40 mg Tablet .
To cope with diarrhea, drink plenty of fluids and eat bland foods like bananas, rice, applesauce, and toast. Avoid trigger foods that can irritate your stomach, and get plenty of rest to help your body recover. If needed, consider taking anti-diarrheal medications, but be sure to consult your doctor first. If your symptoms are severe, last over three days, or are accompanied by fever, abdominal pain, or any other symptoms, seek medical attention promptly.
The common side effects of Afadel 40 mg Tablet may include diarrhoea, rash, decreased appetite, nausea, vomiting, dry skin, mouth sores, nail inflammation, aches, cough, abdominal pain, and itching. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
whatsapp Floating Button

Add to Cart