Acimalone 2 Tablet is used to prevent and treat various types of thromboembolic diseases (blood clots inside blood vessels), including deep vein thrombosis (blood clots in leg veins) and pulmonary embolism (blood clots in the lung). Deep vein thrombosis is a medical condition in which blood clots form in deep veins, usually in the legs. Pulmonary embolism is a condition in which a blood clot blocks the arteries in the lungs.

Acimalone 2 Tablet is prescribed to prevent unwanted clots from forming if you have a condition that puts you at risk of this happening, such as atrial fibrillation, or if you have had a heart valve replacement. It is also given to prevent any clots that may have already formed in the blood vessels of your legs, lungs or heart from becoming larger and causing problems. Acimalone 2 Tablet works by increasing the time it takes for your blood to clot, reducing the risk of a stroke or heart attack. This medication helps to keep blood flowing smoothly in your body by decreasing the amount/number of clotting proteins in the blood. Acimalone 2 Tablet does not dissolve blood clots that have already formed but may stop them from becoming larger and causing more serious problems.

Take Acimalone 2 Tablet, preferably with or without food, and swallow whole with a glass of water. Do not crush, chew or break it. Your doctor will advise you on how often you take your tablets based on your medical condition. Some people may experience unusual bleeding or skin rash. Most of these side effects of Acimalone 2 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Acimalone 2 Tablet or any other medicines, please tell your doctor. If you are pregnant, trying for a baby or breastfeeding, it is advised to consult a doctor before using Acimalone 2 Tablet. If you have any cuts or wounds, stomach ulcers, kidney or liver problems, high blood pressure or bleeding problems or if you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.  Inform your doctor before taking Acimalone 2 Tablet. It would help if you had frequent 'INR' (international normalized ratio) or prothrombin time tests to measure your blood clotting time, as Acimalone 2 Tablet prolongs bleeding time. You must be cautious while shaving and brushing your teeth to avoid too much bleeding from the injury site.

Acimalone 2 Tablet is the popular drug of choice for oral anticoagulant therapy in many indications like calf deep vein thrombosis (blood clots in leg veins), proximal deep vein thrombosis (blood clots in a deep vein), pulmonary embolism (A condition in which one or more arteries in the lungs become blocked by a blood clot), recurrent venous thromboembolism (a blood clot forms most often in the deep veins of the leg, groin or arm), cardioversion, atrial fibrillation (An irregular, often rapid heart rate that commonly causes poor blood flow), antiphospholipid syndrome (A disorder in which the immune system mistakenly attacks normal proteins in the blood) and mechanical heart valves. Acimalone 2 Tablet works by inhibiting the production of clotting factors by decreasing the action of vitamin K. This prevents the conversion of fibrinogen (soluble protein) to fibrin (insoluble protein), thereby preventing blood clot formation.

• Unusual bleeding from the gums
• Heavy bleeding from cuts or wounds
• Unexplained bruising or nosebleeds
• Heavy periods
• Abdominal pain
• Blood vomiting
• Bloody or black tarry stools
• Blood in the urine
• Backache
• Dizziness
• Severe headache
• Weakness in an arm or leg
• Blurred vision
• A blood clot in the eye (visible pool of blood)

Indigestion medicines known as proton pump inhibitors like omeprazole should be used with caution while taking Acimalone 2 Tablet. Prolonged use of Acimalone 2 Tablet can cause bleeding problems (like nosebleeds, heavier periods, bleeding gums, and easy bruising). If you are going to have any surgery, discontinue taking Acimalone 2 Tablet five days before the surgery. Discontinuation of Acimalone 2 Tablet might increase the risk of heart attack, stroke, and other risks of cardiovascular events. So, do not stop taking Acimalone 2 Tablet of a sudden on your own decision. If you have had any recent stroke or heart attack, stop the intake of Acimalone 2 Tablet with painkillers like aspirin or ibuprofen as it can increase your stomach or gastrointestinal bleeding. Purpura (blood leakage under the skin) has been observed using Acimalone 2 Tablet, including fatal cases. If you are pregnant, planning for pregnancy, or are a nursing mother, tell your doctor that you are taking Acimalone 2 Tablet.

Drug-Drug Interactions: Acimalone 2 Tablet may have interaction with other anticoagulants (e.g. heparin, dipyridamole, clopidogrel, ticlopidine), anti-arrhythmic agents (e.g. amiodarone, quinidine), antibiotics (e.g. clindamycin). medicine used against pain (e.g. diacetylsalicylic acid, aminosalicylic acid, diflunisal), an antidepressant (e.g. citalopram), HIV protease inhibitors (e.g. ritonavir, nelfinavir), protease inhibitors (e.g. indinavir, nelfinavir, ritonavir, saquinavir), barbiturates (e.g. Phenobarbital), antacids (e.g. magnesium hydroxide), and proton pump inhibitors (e.g. omeprazole).

Drug-Food Interactions: You should avoid drinking cranberry juice or taking other cranberry products and also Acimalone 2 Tablet may interact with herbs and supplements including include garlic, ginger, bilberry, danshen, piracetam, ginkgo biloba and St John’s wort plant (used as an antidepressant) and increase the risk of bleeding.

Drug-Disease Interactions: Acimalone 2 Tablet should not be given to the people with stomach ulcers, brain haemorrhage (bleeding in your brain), haemophilia (a bleeding disorder), and liver or kidney problems.

• HEPARIN
• CLINDAMYCIN
• CLOPIDOGREL
• CELECOXIB
• METHYLPREDNISOLONE
• ACETYLSALICYLIC ACID
• DIPYRIDAMOLE
• TICLOPIDINE

• A low cholesterol diet and a regular exercise regime complement treatment with Acimalone 2 Tablet effectively.

• As a precautionary measure, you are recommended not to consume alcohol, or junk food items from outside, stick to a freshly prepared home-cooked meal and rest properly for a speedy recovery.

• And also, try to replace most of your saturated fats with unsaturated fats to reduce total cholesterol and LDL in a short time.

• Foods like avocados, olive oil, fatty fish and nuts contain many heart-healthy unsaturated fats, so eating them regularly is beneficial.

• Option for foods that are high in vitamin K (liver, leafy green vegetables, or vegetable oils) as Acimalone 2 Tablet may lower Vitamin K in your body.

• Avoid drinking alcohol as it increases the risk of gastrointestinal ulcer/bleeding.

• Cranberry juice, grapefruit juice, noni juice, and pomegranate juice may interact with Acimalone 2 Tablet and lead to unwanted side effects. Hence try to avoid these juices while taking Acimalone 2 Tablet.

• Caution and more frequent monitoring of platelet count, factor V assay, fibrinogen level test, prothrombin time test (PT or PT-INR) and the INR, or international normalised ratio to analyze your blood clotting time.

• You should NOT receive injections into your muscles whilst taking Acimalone 2 Tablet. If you need any injections into your spine or as part of a scan or X-ray test, or if you need minor surgery, including dental surgery, make sure you discuss your treatment with your doctor first.

Blood clots can occur in any body part, leading to a heart attack, stroke, and organ damage (even coma or death). Blood clots can reach your arteries or veins in organs like the brain, kidney, heart, lungs, and limbs. Conditions like atherosclerosis, diabetes, heart failure, irregular heartbeat (arrhythmia), and obesity/overweight can trigger excessive blood clotting in the brain and heart. On the other hand, deep vein thrombosis (blood clot in veins), peripheral artery disease (narrowed arteries due to fat deposit or blood clot), and atherosclerosis (fat built upon the walls of the arteries) can cause a blood clot in your limbs.

Deep vein thrombosis (blood clots in the legs) is a medical condition in which blood clots form in deep veins, usually in the legs. The symptoms include leg pain or swelling. 

Pulmonary embolism (blood clots in the lung) is a chronic condition which occurs as the blood clots break and travel to the lungs from deep veins in the legs or other parts of the body. The symptoms of pulmonary embolism include cough, chest pain, and shortness of breath.