Trental 400 Tablet belongs to a class of medicines called Hemorrheologic agents (affects blood viscosity), primarily used to treat pain in the legs due to insufficient blood flow (intermittent claudication). It also reduces cramping, numbness, or weakness in the legs on walking in such patients. Intermittent claudication is a peripheral vascular disease in which you have cramp-like pain in your legs when you walk and is caused by an insufficient blood supply in your legs.

Trental 400 Tablet works by decreasing the viscosity (thickness) of blood, allowing it to pass more easily through the blood vessels, especially in the small blood vessels of the hands and feet. It can also increase the distance you can walk without pain since it improves your legs' blood circulation. It is recommended in patients whose pain has not improved even after lifestyle changes like quitting smoking and doing regular exercise.

Trental 400 Tablet should be taken regularly in dose and duration as advised by the doctor. Your doctor will advise you on the exact dosage and how often you have to take Trental 400 Tablet based on your medical condition. You may experience nausea, vomiting, diarrhoea, headache, lightheadedness, sleep problems, intrahepatic cholestasis (removal of bile from the liver is blocked), abdomen pain, constipation, and urine discolouration in some cases. Most of these side effects of Trental 400 Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Trental 400 Tablet should not be stopped abruptly without consulting the doctor as it may lead to unpleasant side effects. Inform your doctor before starting Trental 400 Tablet if you have any kidney or liver disease or plan to become pregnant, or are breastfeeding. Also, lifestyle changes should be continued with Trental 400 Tablet for best results. Do not take Trental 400 Tablet if you ever had bleeding in your brain or the retina of your eyes, heart failure, chest pain, heart disease, and blood pressure.

Trental 400 Tablet contains 'Pentoxyfilline', which is a peripheral vasodilator that works by decreasing the viscosity (thickness) of blood, allowing it to pass more easily through the blood vessels, especially in the small blood vessels of the hands and feet. It can also increase the distance you can walk without pain since it improves your legs' blood circulation. It is recommended in patients whose pain has not improved even after lifestyle changes like quitting smoking and doing regular exercise.

• Nausea
• Vomiting
• Diarrhoea
• Headache
• Lightheadedness
• Sleep problems
• Intrahepatic cholestasis (removal of bile from the liver is blocked)
• Abdomen pain
• Constipation
• Urine discolouration

Do not take Trental 400 Tablet if you are allergic to any of its components. Inform your doctor if you are pregnant or breastfeeding. Before taking Trental 400 Tablet , please tell your doctor if you are using any blood thinners, as it can increase the risk of severe bleeding. Trental 400 Tablet is not intended for prolonged use unless prescribed by a physician. Inform your doctor if have had any type of bleeding in your brain or the retina of your eyes, have low blood pressure (less than 90 mm of Hg), or have had a heart attack, kidney disease, or liver disease. Tell your doctor that you are using Trental 400 Tablet before undergoing any dental or other surgery. Your doctor might stop this medicine before the surgery. Trental 400 Tablet should not be stopped abruptly without consulting the doctor as it may lead to unpleasant side effects. Also, lifestyle changes should be continued with Trental 400 Tablet for best results and a speedy recovery.

Drug-Drug Interaction: Trental 400 Tablet may interact with blood thinners (warfarin, clopidogrel, aspirin), antibiotics (ciprofloxacin), pain relievers (ketorolac, diclofenac, indomethacin), antihypertensive (metoprolol, atenolol, propranolol, prazosin), antidiabetics (metformin, alogliptin, linagliptin, saxagliptin, sitagliptin, canagliflozin), a drug used to treat lung diseases (theophylline), diuretics (furosemide, chlorothiazide, indapamide, metolazone), 

Drug-Food Interaction: No interaction found/established.

Drug-Disease Interaction: Trental 400 Tablet should be taken with caution in people who have bleeding problems, have had a heart attack, liver or kidney disease.

• WARFARIN
• CLOPIDOGREL
• ASPIRIN
• CIPROFLOXACIN
• KETOROLAC
• DICLOFENAC
• INDOMETHACIN
• METOPROLOL
• ATENOLOL
• PROPRANOLOL
• PRAZOSIN
• METFORMIN
• LINAGLIPTIN
• SAXAGLIPTIN
• SITAGLIPTIN
• CANAGLIFLOZIN
• THEOPHYLLINE
• FUROSEMIDE
• CHLOROTHIAZIDE
• INDAPAMIDE
• METOLAZONE

• Opt for a diet rich in whole grains, fruits, veggies, and low-fat dairy products.

• Lsodium chloride (table salt) intake alt) in your daily diet.

• Quitting smoking is the best strategy to lower the risk of heart disease.

• Avoid chronic stress. Try to enjoy and spend time with your loved ones to cope with stress and practice mindfulness techniques.

• Try to include heart-healthy omega-3 fatty acid-containing food drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.

Your doctor may advice you to get regular blood tests done to monitor liver function while taking Trental 400 Tablet as it might cause liver injury.

Intermittent claudication: It is a peripheral vascular disease in which you have cramp-like pain in your legs when you walk and is caused by an insufficient blood supply in your legs.